Results 1 to 10 of about 178,919 (340)

Spinal Nitric Oxide Synthase Type II Increases Neurosteroid-metabolizing Cytochrome P450c17 Expression in a Rodent Model of Neuropathic Pain [PDF]

Exp Neurobiol, 2019
We have previously demonstrated that the neurosteroid dehydroepiandrosterone sulfate (DHEAS) induces functional potentiation of N-methyl-D-aspartate (NMDA) receptors via increases in phosphorylation of NMDA receptor GluN1 subunit (pGluN1). However, the modulatory mechanisms responsible for the expression of the DHEA-synthesizing enzyme, cytochrome ...
Sheu‐Ran Choi, Alvin J. Beitz, Jang‐Hern Lee   +2 more
europepmc   +5 more sources

Inhibition of nitric oxide production of activated mice peritoneal macrophages is independent of the Toxoplasma gondii strain [PDF]

Memorias do Instituto Oswaldo Cruz, 2021
BACKGROUND Toxoplasma gondii causes toxoplasmosis and is controlled by activated macrophages. However, infection of macrophages by tachyzoites induces TGF-β signaling (TGF-s) inhibiting nitric oxide (NO) production.
João Cláudio Damasceno-Sá, Fernanda Silva de Souza, Thiago Alves Teixeira dos Santos, Fábio Conceição de Oliveira, Maria de Fátima Sarro da Silva, Raul Ramos Furtado Dias, Wanderley de Souza, Andrea Cristina Veto Arnholdt, Sergio Henrique Seabra, Renato Augusto DaMatta   +9 more
doaj   +1 more source

Parkia speciosa Hassk. Empty Pod Extract Alleviates Angiotensin II-Induced Cardiomyocyte Hypertrophy in H9c2 Cells by Modulating the Ang II/ROS/NO Axis and MAPK Pathway

Frontiers in Pharmacology, 2021
Cardiac hypertrophy is characteristic of heart failure in patients who have experienced cardiac remodeling. Many medicinal plants, including Parkia speciosa Hassk., have documented cardioprotective effects against such pathologies.
Hawa Nordin Siti, Hawa Nordin Siti, Juriyati Jalil, Ahmad Yusof Asmadi, Yusof Kamisah, Yusof Kamisah   +5 more
doaj   +1 more source

13.03 SYNERGISTIC EFFECT OF ANGIOTENSIN II TYPE 1 RECEPTOR AND ENDOTHELIAL NITRIC OXIDE SYNTHASE GENE POLYMORPHISMS ON ARTERIAL STIFFNESS

Artery Research, 2007
J. Filipovský*, O. Mayer, M. Dolejšová, L. Bolek   +3 more
doaj   +2 more sources

Vasoconstrictor and Pressor Effects of Des-Aspartate-Angiotensin I in Rat

Biomedicines, 2022
This study investigated the vasoactive effects of des-aspartate-angiotensin-I (DAA-I) in male Wistar rats on whole body vascular bed, isolated perfused kidneys, and aortic rings.
Rosemary Wangensteen, Manuel Gómez-Guzmán, Inmaculada Banegas, Isabel Rodríguez-Gómez, Rosario Jiménez, Juan Duarte, Joaquín García-Estañ, Félix Vargas   +7 more
doaj   +1 more source

The Antitumoral Effect of Paris Saponin II on Head and Neck Squamous Cell Carcinomas Mediated via the Nitric Oxide Metabolic Pathway

Frontiers in Cell and Developmental Biology, 2022
Paris saponin has shown great therapeutic value in cancer therapy. We used isolated Paris saponin II (PSII), an active component of Paris saponin, and demonstrated its antitumor effect on human head and neck squamous cell carcinoma cell lines ...
Wenwen Qi, Wenwen Qi, Fangyuan Zhu, Min Wang, Zhenxiao Teng, Zhenxiao Teng, Runtong Xu, Yue Xi, Qiu Meng, Xinhao Wu, Xinhao Wu, Hui Zhao, Min Ma, Xiaozhi Hou, Baowei Wang, Xiaoming Li, Chengcheng Liu, Xiang Zhang, Fenglei Xu, Ming Xia, Ming Xia   +20 more
doaj   +1 more source

Effects of Ovine Monocyte-Derived Macrophage Infection by Recently Isolated Toxoplasma gondii Strains Showing Different Phenotypic Traits

Animals, 2022
Ovine toxoplasmosis is one the most relevant reproductive diseases in sheep. The genetic variability among different Toxoplasma gondii isolates is known to be related to different degrees of virulence in mice and humans, but little is known regarding its
Raquel Vallejo, Julio Benavides, Noive Arteche-Villasol, Mercedes Fernández-Escobar, María Del Carmen Ferreras, Valentín Pérez, Daniel Gutiérrez-Expósito   +6 more
doaj   +1 more source

The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model [PDF]

, 2020
2-Methoxyestradiol is one of the natural 17β-estradiol derivatives and a potential novel anticancer agent currently being under evaluation in advanced phases of clinical trials.
Cappello F., Daca A., Gorska-Ponikowska M., Kuban-Jankowska A., Luu H. H., Marino Gammazza A., Wierzbicka J. M., Wozniak M., Zmijewski M. A.   +8 more
core   +1 more source

Nitric oxide and L-type calcium channel influences the changes in arterial blood pressure and heart rate induced by central angiotesin II

Behavioral and Brain Functions, 2008
We study the voltage dependent calcium channels and nitric oxide involvement in angiotensin II-induced pressor effect. The antipressor action of L-Type calcium channel antagonist, nifedipine, has been studied when it was injected into the third ventricle
Guarda Ismael FMS, Saad Wilson A, Camargo Luiz AA, Santos Talmir AFB   +3 more
doaj   +1 more source

Effect of Icariside II and Metformin on Penile Erectile Function, Histological Structure, Mitochondrial Autophagy, Glucose-Lipid Metabolism, Angiotensin II and Sex Hormone in Type 2 Diabetic Rats With Erectile Dysfunction

Sexual Medicine, 2020
Introduction: Type 2 diabetes mellitus erectile dysfunction (T2DMED) is one of the common complications of type 2 diabetes mellitus (T2DM). Icariside II (ICA II), a flavonoid derived from Epimedium, has been shown to improve erectile function in T2DMED ...
Jian Zhang, MD, Shuang Li, BS, Shiqing Zhang, MS, Yonghui Wang, BS, Shipeng Jin, BS, Chunli Zhao, MS, Wenzeng Yang, MD, Yuexin Liu, MS, Guangqi Kong, MS   +8 more
doaj   +1 more source