Results 121 to 130 of about 1,819 (263)

Resilient hepatic mitochondrial function and lack of iNOS dependence in diet-induced insulin resistance.

PLoS ONE, 2019
Obesity-derived inflammation and metabolic dysfunction has been related to the activity of the inducible nitric oxide synthase (iNOS). To understand the interrelation between metabolism, obesity and NO., we evaluated the effects of obesity-induced NO ...
Pamela A Kakimoto, Bruno Chausse, Camille C Caldeira da Silva, José Donato Júnior, Alicia J Kowaltowski   +4 more
doaj   +1 more source

Differential signaling of inducible nitric oxide synthase induction in Mycobacterium tuberculosis infected alveolar epithelial cell line A549 in response to cytokines IFN-γ, TNF-α and IL-1β

International Journal of Mycobacteriology, 2014
Background: In earlier studies, it was shown that ex vivo Mycobacterium tuberculosis-infected type II alveolar epithelial cells generate de novo nitric oxide (NO), but the mycobactericidal quantity of NO was released only by stimulation of these cells ...
Sugata Roy, Sadhna Sharma, Monika Sharma, Mridula Bose   +3 more
doaj   +1 more source

Anaphylactic shock depends on endothelial Gq/G11 [PDF]

, 2009
Anaphylactic shock is a severe allergic reaction involving multiple organs including the bronchial and cardiovascular system. Most anaphylactic mediators, like platelet-activating factor (PAF), histamine, and others, act through G protein – coupled ...
Nina Wettschureck, Fleming, Ingrid, Schutz, G., Stefan Offermanns, Fleming, I., Angela Wirth, Habermehl, D., Günther Schütz, Offermanns, S., Fißlthaler, Beate, Wirth, A., Moers, Alexandra, Wettschureck, N., Moers, A., Korhonen, H., Habermehl, Daniel, Ingrid Fleming, Fisslthaler, B., Daniel Habermehl, Offermanns, Stefan, Thomas Wieland, Wieland, Thomas, Beate Fisslthaler, Wieland, T., Alexandra Moers, Korhonen, Hanna, Schütz, Günther, Wettschureck, Nina, Hanna Korhonen, Wirth, Angela   +29 more
core   +1 more source

TWEAK/Fn14 Signaling Drives Oxidative Cardiac Injury in Systemic Lupus Erythematosus: Evidence From Patient Biomarker Studies, Lupus Mouse Models, and Cardiomyocyte Assays

Arthritis &Rheumatology, EarlyView.
Objective Cardiac involvement is a major cause of morbidity in systemic lupus erythematosus (SLE). Tumor necrosis factor–like weak inducer of apoptosis (TWEAK) is elevated in SLE, but its contribution to lupus‐associated cardiac injury is unclear. We investigated the role of TWEAK/fibroblast growth factor–inducible 14 (Fn14) signaling in SLE‐related ...
Yale Liu, Zhu Yan, Xueting Peng, Meixuan Li, Juan Wang, Yan Zhang, Xiaoqian Hu, Mingzhu Zhou, Kaixuan Ren, Dan Zhang, Xingyi Guo, Yumin Xia, Huanhuan Huo   +12 more
wiley   +1 more source

Luteoloside Inhibits IL-1β-Induced Apoptosis and Catabolism in Nucleus Pulposus Cells and Ameliorates Intervertebral Disk Degeneration

Frontiers in Pharmacology, 2019
Intervertebral disk degeneration (IDD) is the major cause of low back pain (LBP), which affects 80% of the world’s population. Interleukin 1 beta (IL-1β) is a major inflammatory factor that accelerates disk degeneration, and IL-1β levels increase in ...
Jialiang Lin, Jialiang Lin, Jialiang Lin, Jiaoxiang Chen, Jiaoxiang Chen, Jiaoxiang Chen, Zengjie Zhang, Zengjie Zhang, Zengjie Zhang, Tianzhen Xu, Tianzhen Xu, Tianzhen Xu, Tianzhen Xu, Zhenxuan Shao, Zhenxuan Shao, Zhenxuan Shao, Xiaobin Wang, Xiaobin Wang, Xiaobin Wang, Yuanzhe Ding, Yuanzhe Ding, Yuanzhe Ding, Naifeng Tian, Naifeng Tian, Naifeng Tian, Haiming Jin, Haiming Jin, Haiming Jin, Sunren Sheng, Sunren Sheng, Sunren Sheng, Weiyang Gao, Weiyang Gao, Weiyang Gao, Yan Lin, Yan Lin, Yan Lin, Xiaolei Zhang, Xiaolei Zhang, Xiaolei Zhang, Xiaolei Zhang, Xiangyang Wang, Xiangyang Wang, Xiangyang Wang, Xiangyang Wang   +44 more
doaj   +1 more source

Respostas vasculares mediadas pelo óxido nítrico: efeitos de agentes oxidantes na hiporeatividade à fenilefrina e no relaxamento induzido por tióis [PDF]

, 2005
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Farmacologia.O choque séptico é uma síndrome caracterizada pela presença de hipotensão, hiporeatividade a vasoconstritores e ...
Terluk, Márcia Ribeiro
core  

ANK1 and EPB41 Variants and the Risk of Steroid‐Induced Osteonecrosis

Arthritis &Rheumatology, EarlyView.
Objective Steroid‐induced osteonecrosis of the femoral head (SONFH) is a refractory skeletal disorder influenced by genetic and environmental factors. However, conclusive pathogenic genetic evidence remains elusive due to the limited exploration of rare damaging variants. In this study, we aimed to identify rare variants associated with SONFH.
Shengbao Chen, Xianmin Zhu, Zhongzhong Chen, Wei Chen, Hussam Alkaissi, Zeng Zhang, Yun Gao, Junhui Yin, Xiangtian Yu, Qiong Fu, Youshui Gao, Zhenzhong Zhu, Qianying Cai, Pengwei Zhang, Weibin Chen, Xin Zhao, Xiaojin Wu, Karel Pacak, Dongxu Jin, Chunde Bao, Zhengping Zhuang, Changqing Zhang   +21 more
wiley   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Endothelial Nitric Oxide Synthase Gene Polymorphism (G894T) and Diabetes Mellitus (Type II) among South Indians

, 2020
The objective of the study is to find out whether the endothelial nitric oxide synthase (eNOS) G894T single-nucleotide polymorphism is associated with type 2 diabetes mellitus in South Indian (Tamil) population.
A J Asirvatham, A Poornima, W Isabel, H R Krithiga, T Angeline   +4 more
core  

Avaliação do efeito tipo-antidepressivo da agmatina em um modelo animal de depressão [PDF]

, 2013
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em Neurociências, Florianópolis, 2013A agmatina é uma amina catiônica endógena cuja ação antidepressiva é reportada em diversos ...
Neis, Vivian Binder
core