A new player in cartilage homeostasis: adiponectin induces nitric oxide synthase type II and pro-inflammatory cytokines in chondrocytes [PDF]
Osteoarthritis and Cartilage, 2008 Recent studies revealed a close connection between adipose tissue, adipokines and articular degenerative inflammatory diseases such as rheumatoid arthritis (RA) and osteoarthritis (OA). The goal of this work was to investigate the activity of adiponectin in human and murine chondrocytes and to study its functional role in the modulation of nitric oxide
R. Lago +7 more
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NEURONAL (TYPE I) NITRIC OXIDE SYNTHASE REGULATES NUCLEAR FACTOR ϰ B ACTIVITY AND IMMUNOLOGIC (TYPE II) NITRIC OXIDE SYNTHASE EXPRESSION [PDF]
Japanese Journal of Pharmacology, 1997 Nitric oxide subserves diverse physiologic roles in the nervous system. NO is produced from at least three different NO synthase (NOS) isoforms: neuronal NOS (nNOS), endothelial NOS, and immunologic NOS (iNOS). We show that nNOS is the predominant isoform constitutively expressed in glia.
Hitoshi Togashi +6 more
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Increased hepatic expression of nitric oxide synthase type II in cirrhotic rats
World Journal of Gastroenterology, 2004 To determine the role and effect of nitric oxide synthase type II (NOSII) in cirrhotic rats.Expression of NOSII mRNA was detected by real time RT-PCR. The activity of nitric oxide synthase and serum levels of NO, systemic and portal hemodynamics and degrees of cirrhosis were measured with high sensitive methods. Chinese traditional medicine tetrandrine
Hai Wang
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Two mRNA Transcripts for Inducible (type II) Nitric Oxide Synthase in Fetal, Newborn, and Adult Ovine Lung. • 1960 [PDF]
Pediatric Research, 1998 Although the inducible (type II) Nitric Oxide synthase isoform (iNOS) has been identified in the normal fetal lung, little is known about changes in iNOS expression in the lung during fetal and postnatal development. We studied qualitative and quantitative changes in iNOS mRNA expression in the lungs of fetal, newborn and adult sheep.
Timothy D. Le Cras +2 more
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Signalling pathway involved in nitric oxide synthase type II activation in chondrocytes: synergistic effect of leptin with interleukin-1 [PDF]
Arthritis Research & Therapy, 2005 AbstractThe objective of the present study was to investigate the effect of leptin, alone or in combination with IL-1, on nitric oxide synthase (NOS) type II activity in vitro in human primary chondrocytes, in the mouse chondrogenic ATDC5 cell line, and in mature and hypertrophic ATDC5 differentiated chondrocytes. For completeness, we also investigated
Miguel Otero +4 more
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Nitric Oxide Differentially Regulates Induction of Type II Nitric Oxide Synthase in Rat Vascular Smooth Muscle Cells Versus Macrophages [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2001 Abstract —We studied effects of nitric oxide (NO) released by different NO donors on induction of inducible NO synthase (iNOS) in rat aortic smooth muscle cells (RASMC) and rat macrophage cell line NR8383. iNOS protein expression induced by a CM (interleukin-1β 250 U/mL, interferon-γ 150 U/mL, and tumor necrosis factor-α 150 U ...
H, Zhang, C, Snead, J D, Catravas
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Angiotensin II Type 2 Receptor Decreases Transforming Growth Factor-β Type II Receptor Expression and Function in Human Renal Proximal Tubule Cells. [PDF]
PLoS ONE, 2016 Transforming growth factor-β (TGF-β), via its receptors, induces epithelial-mesenchymal transition (EMT) and plays an important role in the development of renal tubulointersitial fibrosis.
Hui-Lin Guo +3 more
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Transient receptor potential melastatin 7 cation channel kinase new player in angiotensin II–induced hypertension [PDF]
, 2016 Transient receptor potential melastatin 7 (TRPM7) is a bifunctional protein comprising a magnesium (Mg2+)/cation channel and a kinase domain. We previously demonstrated that vasoactive agents regulate vascular TRPM7.
Antunes, Tayze T. +9 more
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Impaired endothelial function of the retinal vasculature in hypertensive patients [PDF]
, 2004 <p><b>Background and Purpose:</b> Arterial hypertension constitutes a central factor in the pathogenesis of stroke. We examined endothelial function of the retinal vasculature as a model of the cerebral circulation.</p> <p ...
Delles, C. +5 more
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Frontiers in Pharmacology, 2019 AimIt is well-established that angiotensin II exerts a dampening effect on the baroreflex within the nucleus tractus solitarii (NTS), the principal brainstem site for termination of baroreceptor afferents and which is densely populated with gamma ...
Laura Légat +6 more
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