Results 41 to 50 of about 178,919 (340)

Upregulation of inducible NO synthase by exogenous adenosine in vascular smooth muscle cells activated by inflammatory stimuli in experimental diabetes [PDF]

, 2016
BACKGROUND: Adenosine has been shown to induce nitric oxide (NO) production via inducible NO synthase (iNOS) activation in vascular smooth muscle cells (VSMCs). Although this is interpreted as a beneficial vasodilating pathway in vaso-occlusive disorders,
Cignarella, Andrea, Gaion, ROSA MARIA, Malorgio, Francesca, Nassi, Alberto, Tedesco, Serena   +4 more
core   +2 more sources

Sex differences in angiotensin II- induced hypertension

Brazilian Journal of Medical and Biological Research, 2007
Sex differences in the development of hypertension and cardiovascular disease have been described in humans and in animal models. In this paper we will review some of our studies which have as their emphasis the examination of the role of sex differences
B. Xue, A.K. Johnson, M. Hay
doaj   +1 more source

A novel long non-coding natural antisense RNA is a negative regulator of Nos1 gene expression [PDF]

, 2015
Long non-coding natural antisense transcripts (NATs) are widespread in eukaryotic species. Although recent studies indicate that long NATs are engaged in the regulation of gene expression, the precise functional roles of the vast majority of them are ...
AC Thénié, B Holmqvist, B Kuzin, B Moreno-Lopez, BL Sopher, C-H Cheng, D Dahary, DS Bredt, E Ciani, E Pavesi, GB Robb, J Chen, J Garthwaite, J-T Li, JB Kelley, JE Fish, JH Brann, K Matsui, KY Kwan, L Zhou, MA Faghihi, MA Packer, ME Evangelopoulos, ME Evangelopoulos, MHT Ling, N Peunova, P Ogilvie, RG Tremblay, S Hindley, S Korneev, SA Korneev, SA Korneev, SA Korneev, SA Korneev, SM Gibbs, SR Vincent, U Forstermann, V Calabrese, Y Zhang   +38 more
core   +1 more source

Malfunction of Vascular Control in Lifestyle-Related Diseases: Mechanisms Underlying Endothelial Dysfunction in the Insulin-Resistant State

Journal of Pharmacological Sciences, 2004
It is tempting to speculate that increased vasoconstriction and loss of endothelium-dependent vasodilation might be etiological factors of elevated blood pressure in the insulin-resistant state.
Kazuya Shinozaki, Kazuhide Ayajiki, Atsunori Kashiwagi, Masahiro Masada, Tomio Okamura   +4 more
doaj   +1 more source

Mitigation effect of galangin against aortic dysfunction and hypertrophy in rats with metabolic syndrome

Heliyon, 2023
Vascular alterations induced by a high-fat diet (HFD) are involved in the development of hypertension. Galangin, a flavonoid, is the major active compound isolated from galangal and propolis.
Poungrat Pakdeechote, Anuson Poasakate, Patoomporn Prasatthong, Prapassorn Potue, Juthamas Khamseekaew, Putcharawipa Maneesai   +5 more
doaj   +1 more source

Pathophysiological Role of Caveolae in Hypertension [PDF]

, 2019
Caveolae, flask-shaped cholesterol-, and glycosphingolipid-rich membrane microdomains, contain caveolin 1, 2, 3 and several structural proteins, in particular Cavin 1-4, EHD2, pacsin2, and dynamin 2.
Daumke, Oliver, Gollasch, Maik, Kaßmann, Mario, Lian, Xiaoming, Matthaeus, Claudia   +4 more
core   +2 more sources

Nitric oxide and TNFα are critical regulators of reversible lymph node vascular remodeling and adaptive immune response. [PDF]

PLoS ONE, 2013
Lymph node (LN) vascular growth, at the level of the main arteriole, was recently characterized for the first time during infection. Arteriole diameter was shown to increase for at least seven days and to occur via a CD4(+) T cell dependent mechanism ...
Stephanie L Sellers, Akiko Iwasaki, Geoffrey W Payne   +2 more
doaj   +1 more source

Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells [PDF]

American Journal of Physiology-Cell Physiology, 1999
In this report, we demonstrate that a fetal mouse skin-derived dendritic cell line produces nitric oxide (NO) in response to the endotoxin [lipopolysaccharide (LPS)] and to cytokines [tumor necrosis factor-α (TNF-α) and granulocyte-macrophage colony-stimulating factor (GM-CSF)].
Cruz, MT, Duarte, CB, Gonçalo, Margarida, Carvalho, AP, Lopes, MC   +4 more
openaire   +3 more sources

Experimental endolymphatic hydrops under action of a type II nitric oxide synthase inhibitor: otoacoustic emissions evaluation and electrocochleography

Brazilian Journal of Otorhinolaryngology, 2006
In experimental endolymphatic hydrops distortion-products otoacoustic emission (dpoae) amplitudes decrease and there is elevation on electrocochleographic thresholds. Some authors found type ii nitric oxide synthase (nos ii) expression in hydropic cochleas and they suggest nitric oxide (no) may be involved in endolymphatic hydrops pathogenesis. The aim
Cláudio Márcio Yudi Ikino, Roseli Saraiva Moreira Bittar, Karina Midori Sato, Newton Macuco Capella   +3 more
openalex   +3 more sources

Inhibition of nitric oxide biosynthesis by anthocyanin fraction of blackberry extract. [PDF]

, 2006
Anthocyanins are natural colorant belonging to the flavonoid family, widely distributed among flowers, fruits, and vegetables. Some flavonoids have been found to possess anticarcinogenic, cytotoxic, cytostatic, antioxidant, and anti-inflammatory ...
CUZZOCREA S, DUGO P, PERGOLA C, ROSSI, ANTONIETTA, SAUTEBIN, LIDIA   +4 more
core   +1 more source