Results 21 to 30 of about 69,950 (233)

Sirtuin 3 deficiency promotes acute kidney injury induced by sepsis via mitochondrial dysfunction and apoptosis [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): To explore the regulation mechanism of Sirtuin 3 (SIRT3) on the mitochondrial function and apoptosis of acute kidney injury (AKI) in septic mice.Materials and Methods: The sepsis-induced AKI model was constructed in the wild-type and SIRT3 ...
Heng Fan, Jian-wei Le, Min Sun, Jian-hua Zhu   +3 more
doaj   +1 more source

The Antitumoral Effect of Paris Saponin II on Head and Neck Squamous Cell Carcinomas Mediated via the Nitric Oxide Metabolic Pathway

Frontiers in Cell and Developmental Biology, 2022
Paris saponin has shown great therapeutic value in cancer therapy. We used isolated Paris saponin II (PSII), an active component of Paris saponin, and demonstrated its antitumor effect on human head and neck squamous cell carcinoma cell lines ...
Wenwen Qi, Wenwen Qi, Fangyuan Zhu, Min Wang, Zhenxiao Teng, Zhenxiao Teng, Runtong Xu, Yue Xi, Qiu Meng, Xinhao Wu, Xinhao Wu, Hui Zhao, Min Ma, Xiaozhi Hou, Baowei Wang, Xiaoming Li, Chengcheng Liu, Xiang Zhang, Fenglei Xu, Ming Xia, Ming Xia   +20 more
doaj   +1 more source

Adventitial Collagen Cross-Linking by Glutaraldehyde Reinforcing Human Saphenous Vein - Implication for Coronary Artery Bypass Grafting [PDF]

Brazilian Journal of Cardiovascular Surgery, 2022
Introduction: A weak venous wall is one of the major reasons contributing to vein graft failure after coronary artery bypass grafting (CABG). We investigated whether adventitial collagen cross-linking by glutaraldehyde reinforces venous wall, preserving ...
Changcheng Liu, Duanduan Chen, Zhenfeng Li, Huanming Xu, Chengxiong Gu   +4 more
doaj   +1 more source

Effects of Ovine Monocyte-Derived Macrophage Infection by Recently Isolated Toxoplasma gondii Strains Showing Different Phenotypic Traits

Animals, 2022
Ovine toxoplasmosis is one the most relevant reproductive diseases in sheep. The genetic variability among different Toxoplasma gondii isolates is known to be related to different degrees of virulence in mice and humans, but little is known regarding its
Raquel Vallejo, Julio Benavides, Noive Arteche-Villasol, Mercedes Fernández-Escobar, María Del Carmen Ferreras, Valentín Pérez, Daniel Gutiérrez-Expósito   +6 more
doaj   +1 more source

Effect of miR-134 against myocardial hypoxia/reoxygenation injury by directly targeting NOS3 and regulating PI3K/Akt pathway [PDF]

Acta Cirúrgica Brasileira, 2019
Purpose To reveal the function of miR-134 in myocardial ischemia. Methods Real-time PCR and western blotting were performed to measure the expression of miR-134, nitric oxide synthase 3 (NOS3) and apoptotic-associated proteins. Lactic dehydrogenase (LDH)
Jian-Min Xiao, Ji-Jia Wang, Li-Li Sun
doaj   +1 more source

Implementation of pro- and anti-inflammatory mechanisms of sirtuin-1 in patients with chronic obstructive pulmonary disease and chronic coronary syndrome and their combination

Zaporožskij Medicinskij Žurnal, 2023
One of the key pathogenetic aspects of chronic obstructive pulmonary disease (COPD) and chronic coronary syndrome (CCS) is endothelial dysfunction.
Ya. V. Chobanu, T. O. Ilashchuk
doaj   +1 more source

Nitric oxide synthase:non-canonical expression patterns [PDF]

, 2014
Science can move ahead by questioning established or canonical views and, so it may be with the enzymes, nitric oxide synthases (NOS). Nitric oxide (NO) is generated by NOS isoforms that are often described by their tissue-specific expression patterns ...
Mattila, Joshua, Thomas, Anita C
core   +3 more sources

Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis [PDF]

, 2009
Insulin stimulates endothelial NO (nitric oxide) synthesis via PKB (protein kinase B)/Akt-mediated phosphorylation and activation of eNOS (endothelial NO synthase) at Ser-1177.
Alasdair R. Boyd, Aljada, Andreozzi, Bauer, Boyle, Christine F. Kohlhaas, Church, Federici, Gallis, Harris, Ian P. Salt, John M. C. Connell, Kenneth Walsh, Kim, Kou, Krishna C. Yalla, Li, Li, Luo, Michell, Morrow, Mount, Potenza, Potenza, Reihill, Repetto, Salt, Steinberg, Stuart A. Ritchie, Takahashi, Tran, Ueda, Zeng   +32 more
core   +4 more sources

The Major Heat Shock Proteins, Hsp70 and Hsp90, in 2-Methoxyestradiol-Mediated Osteosarcoma Cell Death Model [PDF]

, 2020
2-Methoxyestradiol is one of the natural 17β-estradiol derivatives and a potential novel anticancer agent currently being under evaluation in advanced phases of clinical trials.
Cappello F., Daca A., Gorska-Ponikowska M., Kuban-Jankowska A., Luu H. H., Marino Gammazza A., Wierzbicka J. M., Wozniak M., Zmijewski M. A.   +8 more
core   +1 more source

Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy

Haematologica, 2011
Background Sickle cell disease, a genetic red cell disorder inherited in an autosomal recessive manner, occurs throughout the world. Hepatic dysfunction and liver damage may be present in sickle cell disease, but the pathogenesis of these conditions is ...
Angela Siciliano, Giorgio Malpeli, Orah S. Platt, Christophe Lebouef, Anne Janin, Aldo Scarpa, Oliviero Olivieri, Eliana Amato, Roberto Corrocher, Yves Beuzard, Lucia De Franceschi   +10 more
doaj   +1 more source