A high-throughput screening method for determining the substrate scope of nitrilases [PDF]
, 2014 Nitrile compounds are intermediates in the synthesis of pharmaceuticals such as atorvastatin. We have developed a chromogenic reagent to screen for nitrilase activity as an alternative to Nessler's reagent. It produces a semi-quantifiable blue colour and
Black, Gary +5 more
core +1 more source
Identification of an Active Site-bound Nitrile Hydratase Intermediate through Single Turnover Stopped-flow Spectroscopy [PDF]
, 2013 Stopped-flow kinetic data were obtained for the iron-type nitrile hydratase from Rhodococcus equi TG328-2 (ReNHase) using methacrylonitrile as the substrate.
Gumataotao, Natalie +3 more
core +2 more sources
Orthogonal, metal-free surface modification by strain-promoted azide–alkyne and nitrile oxide–alkene/alkyne cycloadditions [PDF]
, 2012 In this article we present a fast and efficient methodology for biochemical surface patterning under extremely mild conditions. Micropatterned azide/benzaldoxime-surfaces were prepared by microcontact printing of a heterobifunctional cyclooctyne oxime ...
Arlinghaus, Heinrich F +6 more
core +1 more source
Frontiers in Pharmacology, 2018 Exposure to ultraviolet B (UVB) irradiation of the skin leads to numerous dermatological concerns including skin cancer and accelerated aging. Natural product glucosinolate derivatives, like sulforaphane, have been shown to exhibit chemopreventive and ...
Evan L. Carpenter +14 more
doaj +1 more source
Nitrile hydratase genes are present in multiple eukaryotic supergroups. [PDF]
PLoS ONE, 2012 Nitrile hydratases are enzymes involved in the conversion of nitrile-containing compounds into ammonia and organic acids. Although they are widespread in prokaryotes, nitrile hydratases have only been reported in two eukaryotes: the choanoflagellate ...
Alan O Marron +2 more
doaj +1 more source
2,6-Dibromo-4-nitrobenzonitrile
IUCrData, 2017 Molecules of the title compound, C7H2Br2N2O2, have C2v symmetry and each lie on a twofold axis that bisects the benzene ring and its nitro and cyano substituents.
Wayland E. Noland, Kenneth J. Tritch
doaj +1 more source
Preparation of Amidoxime Polyacrylonitrile Chelating Nanofibers and Their Application for Adsorption of Metal Ions. [PDF]
, 2013 Polyacrylonitrile (PAN) nanofibers were prepared by electrospinning and they were modified with hydroxylamine to synthesize amidoxime polyacrylonitrile (AOPAN) chelating nanofibers, which were applied to adsorb copper and iron ions. The conversion of the
Hsieh, You-Lo +5 more
core +3 more sources
Crystal structures of methyl 3,5-dibromo-4-cyanobenzoate and methyl 3,5-dibromo-4-isocyanobenzoate
Acta Crystallographica Section E: Crystallographic Communications, 2018 The title crystals, C9H5Br2NO2, are the first reported 2,6-dihalophenyl cyanide–isocyanide pair that have neither three- nor two-dimensional isomorphism. Both crystals contain contacts between the carbonyl O atom and a Br atom.
Wayland E. Noland +4 more
doaj +1 more source
Synthesis of diversely functionalised 2,2-disubstituted oxetanes: fragment motifs in new chemical space [PDF]
, 2015 Novel oxetane motifs incorporating diverse functional groups on the ring are readily accessed by an O–H insertion/cyclisation strategy.
Bull, JA, Croft, RA, Davis, OA
core +1 more source
Synthesis, characterization and study of antibacterial activity of some novel tetrazole derivatives
Orbital: The Electronic Journal of Chemistry, 2011 This work aims at synthesizing novel tetrazole derivatives from phenothiazine. Phenothiazine is first converted into corresponding nitrile by reacting it with aldehyde, sodium metabisulphite and sodium cyanide.
Subramaniyan Arulmurugan +2 more
doaj +1 more source