7-Bromo-1-methyl-2-phenyl-1H-indole-3-carbonitrile
Molbank, 2017 The title compound was prepared by electrophilic aromatic substitution of 7-bromo-1-methyl-2-phenyl-1H-indole with NCTS (N-cyano-N-phenyl-p-toluenesulfonamide).
Rosanna Meine +3 more
doaj +1 more source
Vacuum ultraviolet photoabsorption spectra of nitrile ices for their identification on Pluto [PDF]
, 2016 Icy bodies, such as Pluto, are known to harbor simple and complex molecules. The recent New Horizons flyby of Pluto has revealed a complex surface composed of bright and dark ice surfaces, indicating a rich chemistry based on nitrogen (N2), methane (CH4),
B. N. Raja Sekhar +14 more
core +2 more sources
2,6-Dibromo-4-nitrobenzonitrile
IUCrData, 2017 Molecules of the title compound, C7H2Br2N2O2, have C2v symmetry and each lie on a twofold axis that bisects the benzene ring and its nitro and cyano substituents.
Wayland E. Noland, Kenneth J. Tritch
doaj +1 more source
Synthesis of Simplified Azasordarin Analogs as Potential Antifungal Agents [PDF]
, 2019 A new series of simplified azasordarin analogs was synthesized using as key steps a Diels–Alder reaction to generate a highly substituted bicyclo[2.2.1]heptane core, followed by a subsequent nitrile alkylation.
Dockendorff, Chris, Wu, Yibiao
core +4 more sources
Nitrile-Containing Pharmaceuticals: Efficacious Roles of the Nitrile Pharmacophore [PDF]
Journal of Medicinal Chemistry, 2010 Fraser F. Fleming,* Lihua Yao, P. C. Ravikumar, Lee Funk, and Brian C. Shook Department of Chemistry and Biochemistry, Duquesne University, Pittsburgh, Pennsylvania 15282-1530, Mylan Pharmaceuticals Inc., 781 Chestnut Ridge Road, Morgantown, West Virginia 26505, and Johnson & Johnson Pharmaceutical Research and Development, L.L.C., Welsh and McKean ...
Lee Funk +4 more
openaire +3 more sources
Gordonia hydrophobica Nitrile Hydratase for Amide Preparation from Nitriles [PDF]
Catalysts, 2021 The active pharmaceutical ingredient levetiracetam has anticonvulsant properties and is used to treat epilepsies. Herein, we describe the enantioselective preparation of the levetiracetam precursor 2-(pyrrolidine-1-yl)butanamide by enzymatic dynamic kinetic resolution with a nitrile hydratase enzyme.
Birgit Grill +5 more
openaire +2 more sources
Isotope-specific reactions of acetonitrile (CH3CN) with trapped, translationally cold CCl+ [PDF]
, 2020 The gas-phase reaction of CCl+ with acetonitrile (CH3CN) is studied using a linear Paul ion trap coupled to a time-of-flight mass spectrometer. This work builds on a previous study of the reaction of CCl+ with acetylene and further explores the reactivity of CCl+ with organic neutral molecules.
arxiv +1 more source
STUDIES IN THE PREPARATION OF NITRILES. II. THE PREPARATION OF ALIPHATIC NITRILES. [PDF]
Journal of the American Chemical Society, 1916 n ...
Epps, G. D. van, Reid, E. Emmet
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Crystal structure of ruthenocenecarbonitrile
Acta Crystallographica Section E: Crystallographic Communications, 2015 The molecular structure of ruthenocenecarbonitrile, [Ru(η5-C5H4C[triple-bond]N)(η5-C5H5)], exhibits point group symmetry m, with the mirror plane bisecting the molecule through the C[triple-bond]N substituent.
Frank Strehler +2 more
doaj +1 more source
Peptide Bonds in the Interstellar Medium: Facile Autocatalytic Formation from Nitriles on Water-Ice Grains [PDF]
, 2022 A recent suggestion that acetamide, \ce{CH3C(O)NH2}, could be readily formed on water-ice grains by the acid induced addition of water across the \ce{CN} bond is now shown to be valid. Computational modelling of the reaction between \ce{R-CN} (R = H, \ce{CH3}) and a cluster of 32 molecules of water and one \ce{H3O+} proceeds auto-catalytically to form ...
arxiv +1 more source