Results 51 to 60 of about 159,122 (346)

Inverse electron-demand 1,3-dipolar cycloaddition of nitrile oxide with common nitriles leading to 3-functionalized 1,2,4-oxadiazoles [PDF]

, 2011
A carbamoyl-substituted nitrile oxide was generated upon treatment of easily available 2-methyl-4-nitro-3-isoxazolin-5(2H)-one with THF (not dried); the reaction proceeded efficiently even in the absence of any special reagents and reaction conditions ...
1020, 1021, 1022, 1023, 1024, 1025, 1026, 1027, Ariga, Masahiro, Hirao, Shotaro, Ise, Yumiko, Kobiro, Kazuya, Nishiwaki, Nagatoshi, Okajima, Yoshikazu, Saigo, Kazuhiko, Sawayama, Jun   +15 more
core   +1 more source

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Selection of elastomeric membranes for the removal of volatile organics from water [PDF]

, 1993
A wide range of homogeneous elastomeric membranes has been prepared using dicumylperoxide as a general cross-linking agent. The membranes have been used for both equilibrium sorption measurements and steady-state pervaporation experiments to study ...
Mulder, M.H.V., Nijhuis, H.H., Nijhuis, H.H., Smolders, C.A., Smolders, C.A.   +4 more
core   +2 more sources

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

3,5-Dibromobenzonitrile

IUCrData, 2018
Molecules of the title compound (I), C7H3Br2N, lie on a crystallographic mirror plane that bisects the benzene ring and the cyano group. In the crystal, no C[triple-bond]N...Br or Br...Br short contacts are observed.
Wayland E. Noland, Kenneth J. Tritch
doaj   +1 more source

Preparation of crosslinked 1,2,4-oxadiazole polymer [PDF]

, 1981
New crosslinked 1,2,4-oxadiazole elastomers were prepared by thermally condensing a monomer having the formula H2N(HON)C-R-Q, wherein Q is a triazine ring-forming group such as nitrile or amidine or a mixture of such group with amidoxime, or a mixture of
Kwong, H., Rosser, R. W., Shalhoub, I. M.   +2 more
core   +1 more source

A Comparative Life Cycle Assessment between a Metered Dose Inhaler and Electric Nebulizer [PDF]

, 2017
Life cycle assessment (LCA) evaluates the environmental impact of a product based on the materials and processes used to manufacture the item as well as the item’s use and disposal.
Goulet, Brandon, Mayer, Brooke K., Olson, Lars E.   +2 more
core   +3 more sources

Experimental Analysis and Physics‐Based Analytical Model on Twisted and Coiled Artificial Muscles

Advanced Engineering Materials, EarlyView.
Twisted and coiled artificial muscles made from silver‐coated nylon fibers are investigated through experiments and analytical modeling. The actuators achieve contractions up to 19.3% and specific work of 8 kJ kg−1, though efficiency remains limited (≈0.15%) by thermal losses.
Salvatore Garofalo, Chiara Morano, Leonardo Pagnotta, Luigi Bruno   +3 more
wiley   +1 more source