Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles. [PDF]
Nat Chem Biol, 2020 Eaton JK +22 more
europepmc +2 more sources
Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition [PDF]
Molecules, 2015 An efficient and straight forward procedure for the syntheses of bicyclic isoxazole/isoxazoline derivatives from the corresponding dimethyl-2-(2-nitro-1-aryl/alkyl)-2-(prop-2-yn-1yl)malonates or dimethyl 2-allyl-2-(2-nitro-1-aryl/alkyl ethyl)malonate is ...
Wen-Chang Chen +8 more
doaj +2 more sources
Synthesis of a Novel Tetracyclic Isoxazole by Intramolecular Nitrile Oxide Cycloaddition [PDF]
MolbankIntramolecular cycloadditions have the great advantage of forming two rings simultaneously. We report the use of intramolecular [3 + 2] cycloaddition of the nitrile oxide derived from an N-propargylbenzimidazole oxime in the synthesis of a hitherto ...
Gavin R. Hoffman, Allen M. Schoffstall
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Synthesis of β-D-ribofuranosylbenzazoles using nitrile oxide addition chemistry
ARKIVOC, 2012 A nitrile oxide based route to 2--D-ribofuranosylbenzazoles has been developed. Tri-Obenzoyl--D-ribofuranosylformonitrile oxide (14) was generated from the corresponding carbaldoxime 16 by treatment with NCS/pyridine, followed by base-induced ...
Iain A. S. Smellie, R. Michael Paton
doaj +2 more sources
Molecules, 2011 Studies on the synthesis of macrosphelide B via an intramolecular nitrile oxide-olefin cycloaddition (INOC) is described. In particular, an asymmetric INOC approach using phase transfer catalysts seems to be a potentially efficient and versatile ...
Seung-Mann Paek, Young-Ger Suh
doaj +2 more sources
Rapid Metal -free Macromolecular Coupling via in situ Nitrile Oxide-Activated Alkene Cycloaddition. [PDF]
J Polym Sci A Polym Chem, 2014 Isaacman MJ, Cui W, Theogarajan LS.
europepmc +2 more sources
Unveiling Hydrogen Bonding and Solvent Effects on Directed Nitrile Oxide [3 + 2] Cycloaddition Reactions: Selectivity of 2,2-Dimethylpropane Nitrile Oxide with Cyclopentenylbenzamide: An MEDT Study [PDF]
ACS OmegaSofiane Benmetir +6 more
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Nitrile Oxide/Alkyne Cycloadditions – A Credible Platform for Synthesis of Bioinspired Molecules by Metal‐Free Molecular Clicking [PDF]
, 2012 F. Heaney
semanticscholar +2 more sources
Synthesis of Functionalized 4,5-Dihydroisoxazoles Decorated with the Dimethylphosphinoyl Group
Журнал органічної та фармацевтичної хімії, 2023 Aim. To synthesize a hybrid molecular platform incorporating dimethylphosphinoyl and 4,5-dihydroisoxazole moieties suitable for the creation of focused combinatorial libraries of compounds. Results and discussion.
Andrii V. Fedyk, Bohdan A. Chalyk
doaj +1 more source
A new approach to heterocycle-modified steroids via nitrile oxide intermediates
ARKIVOC, 2008 Alexander V. Baranovsky +3 more
doaj +3 more sources