Inverse electron-demand 1,3-dipolar cycloaddition of nitrile oxide with common nitriles leading to 3-functionalized 1,2,4-oxadiazoles [PDF]
Organic and biomolecular chemistry, 2011 A carbamoyl-substituted nitrile oxide was generated upon treatment of easily available 2-methyl-4-nitro-3-isoxazolin-5(2H)-one with THF (not dried); the reaction proceeded efficiently even in the absence of any special reagents and reaction conditions ...
1020 +15 more
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Orthogonal, metal-free surface modification by strain-promoted azide–alkyne and nitrile oxide–alkene/alkyne cycloadditions [PDF]
, 2012 In this article we present a fast and efficient methodology for biochemical surface patterning under extremely mild conditions. Micropatterned azide/benzaldoxime-surfaces were prepared by microcontact printing of a heterobifunctional cyclooctyne oxime ...
Arlinghaus, Heinrich F +6 more
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Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles. [PDF]
Nat Chem Biol, 2020 Eaton JK +22 more
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An anomalous hydration/dehydration sequence for the mild generation of a nitrile oxide [PDF]
Organic and biomolecular chemistry, 2011 A nitrile oxide containing a carbamoyl group is readily generated upon the treatment of 2-methyl-4-nitro-3-isoxazolin-5(2H)-one with water under mild reaction conditions, even in the absence of special reagents.
884 +19 more
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[3+2] Cycloaddition to a Chiral 5-Methylene-1,3-dioxolan-4-one and Pyrolysis of the Spiro Adducts [PDF]
MoleculesThe [3+2] cycloaddition chemistry of (2S)-5-methylene-2-t-butyl-1,3-dioxolan-4-one, derived from lactic acid, has been examined, and spiro adducts have been obtained with benzonitrile oxide, acetonitrile oxide, diazomethane and diphenyldiazomethane.
R. Alan Aitken +2 more
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Synthesis of β-D-ribofuranosylbenzazoles using nitrile oxide addition chemistry
ARKIVOC, 2012 A nitrile oxide based route to 2--D-ribofuranosylbenzazoles has been developed. Tri-Obenzoyl--D-ribofuranosylformonitrile oxide (14) was generated from the corresponding carbaldoxime 16 by treatment with NCS/pyridine, followed by base-induced ...
Iain A. S. Smellie, R. Michael Paton
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Study on Nitrile Oxide for Low-Temperature Curing of Liquid Polybutadiene. [PDF]
Materials (Basel), 2022 Li P, Wang X.
europepmc +3 more sources
Molecules, 2011 Studies on the synthesis of macrosphelide B via an intramolecular nitrile oxide-olefin cycloaddition (INOC) is described. In particular, an asymmetric INOC approach using phase transfer catalysts seems to be a potentially efficient and versatile ...
Seung-Mann Paek, Young-Ger Suh
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Design and synthesis of amidine-type peptide bond isosteres: application of nitrile oxide derivatives as active ester equivalents in peptide and peptidomimetics synthesis. [PDF]
Organic and biomolecular chemistry, 2011 Amidine-type peptide bond isosteres were designed based on the substitution of the peptide bond carbonyl (C=O) group with an imino (C=NH) group. The positively-charged property of the isosteric part resembles a reduced amide-type peptidomimetic.
Fujii, Nobutaka +7 more
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