Orthogonal, metal-free surface modification by strain-promoted azide–alkyne and nitrile oxide–alkene/alkyne cycloadditions [PDF]
, 2012 In this article we present a fast and efficient methodology for biochemical surface patterning under extremely mild conditions. Micropatterned azide/benzaldoxime-surfaces were prepared by microcontact printing of a heterobifunctional cyclooctyne oxime ...
Arlinghaus, Heinrich F +6 more
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eXPRESS Polymer Letters, 2009 The aim of this work was to study the activity of several nanosized zinc oxides in the crosslinking of carboxylated nitrile elastomer (XNBR). In this article, we discuss the effect of zinc oxide nanoparticles with respect to their specific surface area ...
M. Przybyszewska, Marian Zaborski
doaj +2 more sources
Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles. [PDF]
Nat Chem Biol, 2020 Eaton JK +22 more
europepmc +2 more sources
Rapid Metal -free Macromolecular Coupling via in situ Nitrile Oxide-Activated Alkene Cycloaddition. [PDF]
J Polym Sci A Polym Chem, 2014 Nitrile oxide 1,3 dipolar cycloaddition is a simple and powerful coupling methodology. However, the self-dimerization of nitrile oxides has prevented the widespread use of this strategy for macromolecular coupling.
Isaacman MJ, Cui W, Theogarajan LS.
europepmc +2 more sources
An anomalous hydration/dehydration sequence for the mild generation of a nitrile oxide [PDF]
Organic and biomolecular chemistry, 2011 A nitrile oxide containing a carbamoyl group is readily generated upon the treatment of 2-methyl-4-nitro-3-isoxazolin-5(2H)-one with water under mild reaction conditions, even in the absence of special reagents.
884 +19 more
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Synthesis of Bicyclic Isoxazoles and Isoxazolines via Intramolecular Nitrile Oxide Cycloaddition [PDF]
Molecules, 2015 An efficient and straight forward procedure for the syntheses of bicyclic isoxazole/isoxazoline derivatives from the corresponding dimethyl-2-(2-nitro-1-aryl/alkyl)-2-(prop-2-yn-1yl)malonates or dimethyl 2-allyl-2-(2-nitro-1-aryl/alkyl ethyl)malonate is ...
Wen-Chang Chen +8 more
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Nitrile Oxide/Alkyne Cycloadditions – A Credible Platform for Synthesis of Bioinspired Molecules by Metal‐Free Molecular Clicking [PDF]
, 2012 The need for precise and flexible synthetic methodology to underpin modern research in chemical biology and materials science has fuelled a resurgence of interest in Huisgen 1,3-dipolar cycloaddition chemistry.
F. Heaney
semanticscholar +2 more sources
Design and synthesis of amidine-type peptide bond isosteres: application of nitrile oxide derivatives as active ester equivalents in peptide and peptidomimetics synthesis. [PDF]
Organic and biomolecular chemistry, 2011 Amidine-type peptide bond isosteres were designed based on the substitution of the peptide bond carbonyl (C=O) group with an imino (C=NH) group. The positively-charged property of the isosteric part resembles a reduced amide-type peptidomimetic.
Fujii, Nobutaka +7 more
core +2 more sources
Synthesis of a Novel Tetracyclic Isoxazole by Intramolecular Nitrile Oxide Cycloaddition [PDF]
MolbankIntramolecular cycloadditions have the great advantage of forming two rings simultaneously. We report the use of intramolecular [3 + 2] cycloaddition of the nitrile oxide derived from an N-propargylbenzimidazole oxime in the synthesis of a hitherto ...
Gavin R. Hoffman, Allen M. Schoffstall
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Synthesis of β-D-ribofuranosylbenzazoles using nitrile oxide addition chemistry
ARKIVOC, 2012 A nitrile oxide based route to 2--D-ribofuranosylbenzazoles has been developed. Tri-Obenzoyl--D-ribofuranosylformonitrile oxide (14) was generated from the corresponding carbaldoxime 16 by treatment with NCS/pyridine, followed by base-induced ...
Iain A. S. Smellie, R. Michael Paton
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