Results 31 to 40 of about 29,634 (298)

Side-chain Modifications of Highly Functionalized 3(2H)-Furanones

Molecules, 2012
A series of 3(2H)-furanones, based on side-chain modifications of a parent 3(2H)-furanone, was synthesized in good yield. The parent compound was prepared by hydrogenolysis, and subsequent acid hydrolysis, of isoxazole derivatives.
Gil Valdo José da Silva, Maurício Gomes Constantino, Viviani Nardini, Shirley Muniz Machado Rodrigues   +3 more
doaj   +1 more source

The effect of zinc oxide nanoparticle morphology on activity in crosslinking of carboxylated nitrile elastomer

eXPRESS Polymer Letters, 2009
The aim of this work was to study the activity of several nanosized zinc oxides in the crosslinking of carboxylated nitrile elastomer (XNBR). In this article, we discuss the effect of zinc oxide nanoparticles with respect to their specific surface area ...
doaj   +1 more source

Synthesis of a Novel Tetracyclic Isoxazole by Intramolecular Nitrile Oxide Cycloaddition

Molbank
Intramolecular cycloadditions have the great advantage of forming two rings simultaneously. We report the use of intramolecular [3 + 2] cycloaddition of the nitrile oxide derived from an N-propargylbenzimidazole oxime in the synthesis of a hitherto ...
Gavin R. Hoffman, Allen M. Schoffstall
doaj   +1 more source

Combined experimental and theoretical studies of regio- and stereoselectivity in reactions of β-isoxazolyl- and β-imidazolyl enamines with nitrile oxides

Beilstein Journal of Organic Chemistry, 2016
Reactions of β-azolyl enamines and nitrile oxides were studied by both experimental and theoretical methods. (E)-β-(4-Nitroimidazol-5-yl), (5-nitroimidazol-4-yl) and isoxazol-5-yl enamines smoothly react regioselectively at room temperature in dioxane ...
Ilya V. Efimov, Marsel Z. Shafikov, Nikolai A. Beliaev, Natalia N. Volkova, Tetyana V. Beryozkina, Wim Dehaen, Zhijin Fan, Viktoria V. Grishko, Gert Lubec, Pavel A. Slepukhin, Vasiliy A. Bakulev   +10 more
doaj   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Preparation of in situ modified hydrogenated nitrile rubber with unsaturated carboxylic acid from biomass

Hecheng xiangjiao gongye
Zinc sorbate (ZDS) reinforced hydrogenated nitrile rubber was prepared using sorbic acid and zinc oxide as raw materials by in situ generation method, and the in situ reaction mechanism of sorbic acid and effect of zinc sorbate on physical and mechanical
XUE Ao-nan, LIU Da-chen, ZHU Bo-cong, XIAO Xiao-kun
doaj   +1 more source

Facile and green synthesis of 3,5-disubstituted isoxazoles using doped nano-sized copper(I) oxide (Cu2O) on melamine–formaldehyde resin as an efficient nano-catalyst under ultrasonic irradiation [PDF]

شیمی کاربردی روز, 2019
In the present research, doped nano-sized copper(I) oxide (Cu2O) on melamine–formaldehyde resin as a heterogeneous and efficient nano-catalyst has been employed for green and mild synthesis of 3,5-disubstituted isoxazoles under ultrasonic irradiation. In
Somayeh Behrouz
doaj   +1 more source

The preparation of ketene dithioacetals and thiophenes from chloropyridines containing an active methylene group [PDF]

, 2010
The base catalysed reaction of carbon disulphide with the active methylene groups of chloropyridines 4 and 7, followed by alkylation with reagents which also contain active methylene groups, lead to ketene dithioacetals.
Bremner, David H., Sturrock, Keith R., Wishart, Grant   +2 more
core   +3 more sources

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source