Results 41 to 50 of about 2,971,196 (335)

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Preparation of in situ modified hydrogenated nitrile rubber with unsaturated carboxylic acid from biomass

Hecheng xiangjiao gongye
Zinc sorbate (ZDS) reinforced hydrogenated nitrile rubber was prepared using sorbic acid and zinc oxide as raw materials by in situ generation method, and the in situ reaction mechanism of sorbic acid and effect of zinc sorbate on physical and mechanical
XUE Ao-nan, LIU Da-chen, ZHU Bo-cong, XIAO Xiao-kun
doaj   +1 more source

Improving Thermo-Oxidative Stability of Nitrile Rubber Composites by Functional Graphene Oxide

Materials, 2018
Graphene oxide (GO), modified with anti-aging agent p-phenylenediamine (PPD), was added into nitrile rubber (NBR) in order to improve the thermo-oxidative stability of NBR.
R. Zhong, Zhao Zhang, Hongguo Zhao, Xianru He, Xin Wang, Rui Zhang   +5 more
semanticscholar   +1 more source

Phenotypic plasticity in a novel set of EGFR tyrosine kinase inhibitor‐adapted non‐small cell lung cancer cell lines

FEBS Open Bio, EarlyView.
Phenotypic plasticity in a newly established set of EGFR inhibitor‐adapted NSCLC cell lines during adaptation and in established cell lines. Here, we introduce novel sublines of the EGFR‐mutant non‐small cell lung cancer (NSCLC) cell lines HCC827 and HCC4006 adapted to the EGFR kinase inhibitors gefitinib (HCC827rGEFI2μm, HCC4006rGEFI1μm), erlotinib ...
Tharsagini V. Nanthaprakash, Campbell W. Gourlay, Ina Oehme, Michelle D. Garrett, Jindrich Cinatl Jr, Mark N. Wass, Martin Michaelis   +6 more
wiley   +1 more source

Short‐term actions of epigalocatechin‐3‐gallate in the liver: a mechanistic insight into hypoglycemic and potential toxic effects

FEBS Open Bio, EarlyView.
Epigallocatechin‐3‐gallate (EGCG) acutely inhibited gluconeogenesis and enhanced glycolysis, glycogenolysis, and fatty acid oxidation in perfused rat livers. Mechanistic assays revealed mitochondrial uncoupling, inhibition of pyruvate carboxylation and glucose‐6‐phosphatase, shift of NADH/NAD+ ratios toward oxidation, and loss of membrane integrity ...
Carla Indianara Bonetti, Bruna Lopes Correia, Francielle Cristina Nakamura Manicardi, Nairana Mithieli de Queiroz Eskuarek Melo, Vanesa de Oliveira Pateis, Jurandir Fernando Comar, Anacharis Babeto de Sá‐Nakanishi, Adelar Bracht, Lívia Bracht   +8 more
wiley   +1 more source

A Molecular Electron Density Theory Study of the Chemoselectivity, Regioselectivity, and Diastereofacial Selectivity in the Synthesis of an Anticancer Spiroisoxazoline derived from α-Santonin

Molecules, 2019
The [3 + 2] cycloaddition (32CA) reaction of an α-santonin derivative, which has an exocyclic C⁻C double bond, with p-bromophenyl nitrile oxide yielding only one spiroisoxazoline, has been studied within the molecular electron density theory ...
Luis R. Domingo, Mar Ríos-Gutiérrez, Nivedita Acharjee   +2 more
doaj   +1 more source

Facile and green synthesis of 3,5-disubstituted isoxazoles using doped nano-sized copper(I) oxide (Cu2O) on melamine–formaldehyde resin as an efficient nano-catalyst under ultrasonic irradiation [PDF]

شیمی کاربردی روز, 2019
In the present research, doped nano-sized copper(I) oxide (Cu2O) on melamine–formaldehyde resin as a heterogeneous and efficient nano-catalyst has been employed for green and mild synthesis of 3,5-disubstituted isoxazoles under ultrasonic irradiation. In
Somayeh Behrouz
doaj   +1 more source

Bioorthogonal Engineering of Cellular Microenvironments Using Isonitrile Ligations

Advanced Functional Materials, EarlyView.
Highly selective chemistries are required for fabrication and post‐cross–linking modification of cell‐encapsulating hydrogels used in tissue engineering applications. Isonitrile ligation reactions represent a promising class of bioorthogonal chemistries for engineering hydrogel‐based cellular microenvironments. Isonitrile‐based hydrogels are stable and
Ping Zhou, Lauren Brown, Christopher M. Madl   +2 more
wiley   +1 more source

Effect of different charge number metal ions on mechanical properties of carboxylated nitrile rubber composites

Hecheng xiangjiao gongye
Three types of metal oxide, magnesium oxide(MgO), zinc oxide(ZnO) and aluminium oxide(Al2O3), were added into carboxylated nitrile rubber (XNBR) to prepared XNBR/metal oxide composites, the properties of which, such as interactions between metal ions and
LUO Jiang1, XIE Qing-jun1, YANG Shu-yan2
doaj   +1 more source

Synthesis and Antimicrobial Activity of some Ester Functionalized Isoxazoles incorporating Anthracene Moieties via Nucleophilic Substitution Reaction

Zanco Journal of Medical Sciences, 2023
Background and objective: Five-membered heterocycle compounds having single oxygen and nitrogen atom at adjacent positions are known as isoxazoles. Isoxazole compounds have a broad range of biological activities and therapeutic value.
Sarbast M. Ahmed, Hewa Omer Ahmed, Faiq H. S. Hussain, Hayman Sardar Abdulrahman, Hemn A. Qader   +4 more
doaj