Results 51 to 60 of about 6,046 (231)

The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching [PDF]

Significance: a mismatch between energy supply and demand induces tissue hypoxia with the potential to cause cell death and organ failure. Whenever arterial oxygen concentration is reduced, increases in blood flow - 'hypoxic vasodilation' - occur in an ...
Feelisch, Martin, Umbrello, Michele, Dyson, Alex, Singer, Mervyn   +3 more
core   +1 more source

Copper‐Containing Nitrite Reductase

, 2022
Cu‐containing nitrite reductases (CuNiRs) catalyze the reduction of nitrite to nitric oxide and water. CuNiRs are part of the denitrification and nitrification pathways that are not only important from bioenergetics perspective but are also the major ...
S. Samar Hasnain, Rose, Samuel L, Eady, Robert R, Svetlana V Antonyuk, Robert R Eady, Antonyuk, Svetlana V, Hasnain, S Samar, Michael A Hough, Hough, Michael A, Samuel L Rose   +9 more
core   +1 more source

Spectroscopically validated multiple structures from one crystal (MSOX) and Damage Free atomic structures using XFEL for copper Nitrite Reductases [PDF]

, 2023
Many enzymes utilize redox-coupled centres for performing catalysis where the centres are used to control and regulatethe transfer of electrons required for catalysis, whose untimely delivery can lead to a state incapable of binding thesubstrate i.e.
Eady, Robert R., Ferroni, Felix, Rose, Samuel L, Antonyuk, Svetlana V., Antonyuk, Svetlana V, Hasnain, S. Samar, Tosha, Takehiko, Ferroni, Felix Martín, Rose, Samuel L., Eady, Robert R, Hasnain, S Samar, Yamamoto, Masaki, Owen, Robin, Horrell, Samuel   +13 more
core   +1 more source

Light-Independent Nitrogen Assimilation in Plant Leaves: Nitrate Incorporation into Glutamine, Glutamate, Aspartate, and Asparagine Traced by ¹⁵N

Plants, 2020
Although the nitrate assimilation into amino acids in photosynthetic leaf tissues is active under the light, the studies during 1950s and 1970s in the dark nitrate assimilation provided fragmental and variable activities, and the mechanism of reductant ...
Tadakatsu Yoneyama, Akira Suzuki
doaj   +1 more source

Nano‐Backpack Engineered Probiotics with Reactive Oxygen Species–Responsive Tungsten Release for Synergistic Therapy of Inflammatory Bowel Disease

Advanced Science, EarlyView.
An integrated probiotic system is engineered to execute a programmed therapeutic cascade against inflammatory bowel disease. Upon pathological signals, the system sequentially performs ROS scavenging, tungsten release, and selective pathogen suppression, thereby breaking the oxidative stress–dysbiosis cycle to remodel gut microbiota and reinforce ...
Yang Yang, Liucan Wang, Guoqing Chen, Yuanling Zhang, Jiarui Shi, Wenzhe Fan, Min Yu, Jixi Zhang, Hua Yang   +8 more
wiley   +1 more source

The electron transport chains of Neisseria meningitidis [PDF]

, 2007
Neisseria meningitidis contains c-type and b-type cytochromes. Oxidation of c-type and b-type cytochromes by oxygen was observed in both cells grown under aerobic and denitrifying conditions, whereas oxidation of cytochromes by nitrite was only seen in ...
Deeudom, Manu
core  

Nitrate Reductase Regulates Expression of Nitrite Uptake and Nitrite Reductase Activities in Chlamydomonas reinhardtii [PDF]

Plant Physiology, 1992
In Chlamydomonas reinhardtii mutants defective at the structural locus for nitrate reductase (nit-1) or at loci for biosynthesis of the molybdopterin cofactor (nit-3, nit-4, or nit-5 and nit-6), both nitrite uptake and nitrite reductase activities were repressed in ammonium-grown cells and expressed at high amounts in nitrogen-free media or in media ...
A, Galván, J, Cárdenas, E, Fernández
openaire   +2 more sources

Uncovering Cystic Fibrosis Carrier: Insights From a Heterozygous CFTR‐F508del Rabbit Model

International Forum of Allergy &Rhinology, EarlyView.
ABSTRACT Background Chronic rhinosinusitis (CRS) is a heterogeneous inflammatory disorder frequently associated with impaired mucociliary clearance and bacterial infection. Individuals carrying a single cystic fibrosis transmembrane conductance regulator (CFTR) mutation exhibit partial CFTR dysfunction and are increasingly recognized as being at risk ...
Do‐Yeon Cho, Alexis E. McFeely, Daniel Skinner, Shaoyan Zhang, Justin Hedvat, Weslee Ping‐ay, Daniel M. Beswick, Justin H. Turner, Bradford A. Woodworth, Jie Xu   +9 more
wiley   +1 more source

Nitrite and Nitrite Reductases: From Molecular Mechanisms to Significance in Human Health and Disease

, 2012
Nitrite, previously considered physiologically irrelevant and a simple end product of endogenous nitric oxide (NO) metabolism, is now envisaged as a reservoir of NO to be activated in response to oxygen (O-2) depletion.
Cutruzzolà, Francesca, CASTIGLIONE, NICOLETTA, GIARDINA, Giorgio, RINALDO, Serena, CUTRUZZOLA', Francesca, STELITANO, Valentina   +5 more
core   +1 more source

Immunoinformatics‐Based Design of a Multi‐Epitope Vaccine Targeting a Conserved Copper–Associated Protein in Neisseria gonorrhoeae

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Neisseria gonorrhoeae poses an urgent public health challenge due to rapidly increasing antimicrobial resistance and the absence of an effective vaccine. Targeting conserved bacterial pathways involved in essential physiological processes may provide new opportunities for vaccine antigen discovery.
Sinethemba H. Yakobi, Uchechukwu U. Nwodo   +1 more
wiley   +1 more source