Results 51 to 60 of about 573 (176)

Formation of 4-Methylphenanthrenes in Palladium-Catalyzed Annulation of Diethyl 2,2‘-Diiodo-4,4‘-biphenyldicarboxylate with Internal Alkynes, Using Methyl Nitrobenzoates as the Methylating Agent

, 2016
The reaction of diethyl 2,2‘-diiodo-4,4‘-biphenyldicarboxylate (7) with diarylacetylenes in the presence of 3,5-(NO2)2C6H3CO2Me (MeDNB) or 4-(NO2)C6H4CO2Me (MePNB), Pd(OAc)2 (10 mol %), K2CO3, and Bu4NBr, in DMF at 100 °C, gives 4-methyl-9,10-diaryl-2,7 ...
Shie-Ming Peng (1425703), Ashis Baran Mandal (2456986), Man-kit Leung (1415257), Gene-Hsiang Lee (1470748), Yi-Hung Liu (1425700)   +4 more
core   +1 more source

Progress in Synthesis and Pharmacology of Telmisartan

Chemistry &Biodiversity, Volume 23, Issue 9, September 2026.
Telmisartan is a benzimidazole derivative and a well‐known drug to treat hypertension. This review provides synthesis and understanding of telmisartan as an antihypertensive drug through two mechanisms of actions: RAAS inhibitor and PPARγ receptor. Effective repurposing of this drug for various diseases like chronic kidney illness, diabetes, fatty ...
Megha, Richa Srivastava, Ram Singh
wiley   +1 more source

Sulfonamide‐Based 2‐Amino‐1,3,4‐Oxadiazole Derivatives as Dual Cholinesterase and Carbonic Anhydrase Inhibitors: Design, Synthesis, Kinetic Characterization, Molecular Modeling, and ADMET Evaluation

Drug Development Research, Volume 87, Issue 6, September 2026.
ABSTRACT In this study, 12 novel sulfonamide derivatives incorporating 2‐amino‐1,3,4‐oxadiazole and 1,3‐benzazol‐2(3H)‐one scaffolds were synthesized and structurally characterized using 1H NMR, 13C NMR, and LC–MS analyses. Their inhibitory activities were evaluated against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), carbonic anhydrase I
Gülnur Arslan Karahan, Başak Gökçe, Muhammed Tilahun Muhammed, Emre Kadir Ayan, Azime Berna Özçelik   +4 more
wiley   +1 more source

Structural study of mefloquinium salts with three isomeric n-nitrobenzoates (n = 2, 3, and 4)

, 2010
The crystal and molecular structures of three racemic erythro-(R*, S*)-(±)-α-2-piperidinyl-2,8-bis(trifluoromethyl)-4-quinolinemethanol n-nitrobenzoates, n = 2, 3, and 4, are described.
Solange M. S. V. Wardell, Edward R. T. Tiekink, James L. Wardell, Janet M.S. Skakle   +3 more
core   +1 more source

Preserved mitochondrial respiration in presence of oxidative stress and reduced mitochondrial mass after 10‐day bed rest in older adults

The Journal of Physiology, Volume 604, Issue 18, Page 7772-7798, 15 September 2026.
Abstract figure legend Ten older healthy male adults underwent 10 days of bed rest. Vastus lateralis muscle biopsies were collected at baseline (PRE) and after 10 days of bed rest (BR10), and mitochondrial adaptations were assessed using an integrative approach combining respirometry, protein analyses, RNA sequencing and transmission electron ...
Evgeniia Motanova, Lucrezia Zuccarelli, Evgenii Lysenko, Stefano Amoretti, Marco Pirazzini, Ornella Rossetto, Lorenza Brocca, Roberto Bottinelli, Maria Antonietta Pellegrino, Giovanni Baldassarre, Clarissa Gissi, Giovanna Lippe, Mladen Gasparini, Boštjan Šimunic, Rado Pišot, Bruno Grassi, Marco V. Narici   +16 more
wiley   +1 more source

Stereoselective Higher‐Order [10+4]‐ and [10+6] Cycloadditions Between Two Highly Unsaturated and Ambiphilic π‐Addends

Chemistry – A European Journal, Volume 32, Issue 31, 18 August 2026.
Aminocatalytically generated isobenzofulvenes and 3‐oxidopyridinium betaines act as ambiphilic reaction partners in orbital‐symmetry‐allowed [10+4] cycloadditions or formally symmetry‐forbidden concerted thermal [10+6] cycloadditions. The reaction furnishes three cycloadducts: one [10+4] cycloadduct and two regioisomeric [10+6] cycloadducts.
Jonas Faghtmann, Anne Kristensen, Fabien Fritz, Signe Sofie Pladsbjerg Andresen, Anne Rask Østergaard, Johannes Nygaard Lamhauge, K. N. Houk, Karl Anker Jørgensen   +7 more
wiley   +1 more source

Synthesis of 4‐Hydroxyacetophenone‐Derived Bis‐Schiff Bases as Potent Cholinesterase Inhibitors: In Vitro Evaluation, Molecular Docking, DFT, and ADMET Analysis

Chemistry &Biodiversity, Volume 23, Issue 8, August 2026.
A series of 4‐hydroxyacetophenone‐based bis‐Schiff bases were synthesized as dual cholinesterase inhibitors. Compound 2i showed the highest AChE and BuChE inhibition, supported by molecular docking, DFT, QTAIM, and ADMET studies. SAR analysis revealed the role of methoxy substitution in enhancing activity, highlighting 2i as a promising lead candidate ...
Muhammad Daud, Zainab Zainab, Aftab Alam, Imtiaz Ahmad, Ahmed A. Elhenawy, Abdul Latif, Mumtaz Ali, Syed Adnan Ali Shah, Syahrul Imran, Ashwag S. Alanazi, Mohammed M. Alanazi, Manzoor Ahmad   +11 more
wiley   +1 more source

Steric effects on reaction rates. XI. Solvolysis of tertiary carbon substrates rationalized by molecular mechanics calculations

, 1989
The steric energy difference (Est) between tertiary carbenium ions (R+) and the corresponding alcohols has been calculated by MM2 for a series of tertiary nonbridgehead substrates and correlated with their rate of solvolytic reactivity.
Mareda, Jiri, Muller, Paul
core   +1 more source

The X‐Ray Crystal Structure of BorF, the Flavin Reductase Subunit of a Two‐Component Flavin‐Dependent Tryptophan Halogenase

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 8, Page 1529-1540, August 2026.
ABSTRACT BorF is a short‐chain flavin reductase from a desert soil bacterium that uses NADH to reduce FAD to FADH2, which is used by the tryptophan‐6‐halogenase BorH to chlorinate tryptophan in the biosynthetic pathway of borregomycin A. The X‐ray crystal structure of BorF bound to FAD was solved to 2.37 Å by molecular replacement.
Zheng Ma, Emily W. Rady, Aravinda J. de Silva, John J. Bellizzi III   +3 more
wiley   +1 more source

Conversion reactions of cepham into penam systems. A route to determine the relative configurations of two diastereoisomeric 3-bromo-4-methoxycepham derivatives

, 1986
The p-nitrobenzoates I were stereospecifically transformed with AgOAc-AcOH into the penam derivs. II. Oxidn. of II yielded the (S)- and (R)-sulfoxides.
B. MACCHIA, P. DOMIANO, ROSSELLO, ARMANDO, F. MACCHIA P. SCATENA, A. BALSAMO   +4 more
core   +1 more source