FEBS Letters, Volume 600, Issue 2, Page 251-266, January 2026.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
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Acta Crystallographica Section E, 2011 The asymmetric unit of the title co-crystal, C8H12N+·C7H4NO4−·C7H5NO4, contains two cations, two anions and two neutral 4-nitrobenzoic acid molecules. In the crystal, O—H...O, N—H...O and C—H...O hydrogen bonds connect the ions and molecules, forming a three-dimensional network.
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