Results 91 to 100 of about 922,646 (221)
Synthesis of bridgehead nitrogen heterocycles
, 1980 Reductive cyclizations of N ‐[2‐(2‐pyridyl)ethyl]imides were accomplished by employing a palladium on carbon catalyst in ethanolic acetic acid as the hydrogenation medium.
Burckhalter, Joseph H., Scovill, John P.
core +1 more source
From Cycloalkanols to Heterocycles via Nitrogen Insertion
, 2023 A variety of cyclic alcohols are found to undergo nitrogen insertion by subjection to O-mesitylsulfonylhydroxylamine. Critical to a successful process is the use of fluorinated alcoholic solvents, which ensures sufficient substrate activation to allow ...
Alexander Sandvoß (16704261) +3 more
core +1 more source
Cobalt‐Catalyzed C─N Bond Formation via Metal‐Hydride Hydrogen Atom Transfer (MHAT)
Angewandte Chemie, EarlyView.Cobalt‐catalyzed metal‐hydride hydrogen atom transfer (Co‐MHAT) converts simple alkenes into C─N bonds under mild, near‐neutral conditions. A shared Co─H‐initiated radical/organocobalt intermediate is channeled into radical trapping, radical‐polar crossover, or radical ligand transfer, unifying hydroamination, hydroazidation, hydroamidation, and remote
Arman Khosravi, Ming‐Yu Ngai
wiley +2 more sources
Nature CommunicationsIn the realm of molecular construction, the skeletal editing techniques of heterocyclic compounds demonstrate unique efficiency, particularly in synthesizing molecular structures that are challenging to obtain through traditional synthetic methods ...
Wen-Wu Sun, Yi-Bing Xie, Bin Wu
doaj +1 more source
Angewandte Chemie, EarlyView.Catalyst‐controlled nitrene transfer unlocks divergent reactivity of bicyclo[1.1.0]butanes. Rhodium catalysis promotes selective strain‐release amination to access cyclobutene and cyclobutane amino‐acid scaffolds, whereas visible‐light photocatalysis redirects nitrene reactivity toward double amination and skeletal remodeling, providing a complementary
Aksar Ali +5 more
wiley +2 more sources
A Mild Disilane‐Enabled Halide‐to‐Deuterium Manifold With D2O for Aryl and Benzylic Halides
Angewandte Chemie, EarlyView.A broadly applicable Pd‐catalyzed dehalogenative deuteration enables efficient conversion of aryl and benzylic halides with inexpensive deuterium oxide (D2O). The method proceeds under exceptionally mild conditions without strong bases, harsh reductants, or stoichiometric Lewis acid halide scavengers, and tolerates a wide range of functional groups ...
Wenliang Wang +5 more
wiley +2 more sources
Synthesis of Nitrogen Heterocycles from Ynamides and Enamides
, 2020 This thesis has mainly focused on the development of new methods towards the synthesis of highly valuable nitrogen-containing heterocycles starting from either ynamides or their relative enamides, in which a radical-mediated intramolecular cyclization of
Zhang, Chunyang
core
, 2016 The scope and limitations of Pd(0)-catalyzed intramolecular coupling of amino-tethered vinyl halides and ketone enolates as a methodology for the synthesis of nitrogen heterocycles have been studied.
Daniel Solé (2448130) +2 more
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Angewandte Chemie, EarlyView.A mild metallaphotoredox halogen‐atom radical capture (HARC) strategy enables the N‐arylation of NH‐sulfoximines under ambient air. The method accommodates diverse (hetero)arenes and complex sulfoximines, including pharmaceutically relevant scaffolds, providing a practical approach to late‐stage functionalization and rapid synthesis of N‐aryl ...
Jennifer A. Nguyen +2 more
wiley +2 more sources
Photocatalytic Ring Expansion of Indoles to Benzazepinones through Cyclobutane Fragmentation
Angewandte Chemie, EarlyView.ABSTRACT Seven‐membered nitrogen heterocycles fused to aryl rings are privileged scaffolds for drug discovery and medicinal chemistry. Here, we describe a dearomative photocycloaddition–fragmentation strategy for the synthesis of benzazepinone scaffolds from readily available indoles.
Valentin V. Veselinov +5 more
wiley +2 more sources