Results 111 to 120 of about 1,403,091 (264)

Coordination‐Driven Direct C─H Metalation of N‐Heterocycles With a Superbasic Co(II) Amide Co(TMP)2

Angewandte Chemie, EarlyView.
By enabling regioselectivities that are inaccessible with conventional bases, this study introduces a Co(II) amide platform for the deprotonative C─H metalation of sensitive N‐heterocycles. Subsequent interception of the resulting Co(II) intermediates with external oxidants affords a family of sterically congested, TMP‐substituted heterocycles via C─N ...
Na Jin, Manting Mu, Max García‐Melchor, Eva Hevia   +3 more
wiley   +2 more sources

Methylene Insertion into Nitrogen‐Heteroatom Single Bonds of 1,2‐Azoles via a Zinc Carbenoid: An Alternative Tool for Skeletal Editing

Advanced Science
The nitrogen‐heteroatom single bonds of 1,2‐azoles and isoxazolines underwent methylene insertion in the presence of CH2I2 (6 equiv.) and diethylzinc (3 equiv.) to produce a wide variety of the ring‐expanded six‐membered heterocycles.
Masato Tsuda, Taiki Morita, Yuto Morita, Jun Takaya, Hiroyuki Nakamura   +4 more
doaj   +1 more source

Polycyclic nitrogen heterocycles as potential thymidine phosphorylase inhibitors: synthesis, biological evaluation, and molecular docking study. [PDF]

J Enzyme Inhib Med Chem, 2022
Aknin K, Bontemps A, Farce A, Merlet E, Belmont P, Helissey P, Chavatte P, Sari MA, Giorgi-Renault S, Desbène-Finck S.   +9 more
europepmc   +1 more source

Unraveling Terminal Cobalt–Antimony Double Bond: Breaking New Ground in Heavy Pnictogen Multiple Bonds

Angewandte Chemie, EarlyView.
N‐heterocyclic carbenes (NHCs) function as “molecular scissors,” cleaving otherwise inert Sb═Sb bonds in distibenes to generate monomeric, zwitterionic stibinide species. These intermediates act as efficient stibinidene transfer reagents, granting access to a rare terminal cobalt–stibinidene complex.
Daniel Meleschko, Prasenjit Palui, Rosa M. Gomilia, Morgan J. McKee, Gregor Schnakenburg, Nikolay Kornienko, Antonio Frontera, Alessandro Bismuto   +7 more
wiley   +2 more sources

Borylcyclopropanes: Synthetic Strategies and Applications

Angewandte Chemie, EarlyView.
Borylcyclopropanes (cyclopropanes bearing a boron substituent) sit at the intersection of two privileged frameworks in synthesis. This review provides the first exhaustive survey of their chemistry, spanning metal–carbene, nucleophilic cyclization, radical, hydroboration, and C─H activation routes, and documenting applications in medicinal chemistry ...
Aiza A. Butt, Joseph M. Ready
wiley   +2 more sources

An Enantioselective Alkene Aminoarylation to Form Chiral Indolines via Electrostatically‐Directed Palladium Catalysis

Angewandte Chemie, EarlyView.
Enantioselective aminoarylation of ortho‐allyl anilines is achieved under mild conditions. Key to success is the electrostatically‐directed nature of the key aminopalladation step, achieved by using the sulfonated chiral ligand sSPhos on palladium. A detailed study of electronic trends allows tuning of the sulfonamide protecting group to enable good ...
Max Kadarauch, Paul T. Jirsch, H. Erik Diepers, Hamzah Sharif, Robert J. Phipps   +4 more
wiley   +2 more sources

QSAR and Pharmacophore Modeling of Nitrogen Heterocycles as Potent Human N-Myristoyltransferase (Hs-NMT) Inhibitors. [PDF]

Molecules, 2021
Zaki MEA, Al-Hussain SA, Masand VH, Akasapu S, Lewaa I.   +4 more
europepmc   +1 more source

Remapping the Synthetic Landscape of α‐Tertiary Alkylamines via Dual‐Functional Catechol

Angewandte Chemie, EarlyView.
A three‐component assembly strategy has been developed for the modular synthesis of hindered α‐tertiary aliphatic amines from readily available precursors through unlocking the dual role of catechol. The practicality of this methodology has been demonstrated in over 90 examples, including compounds that are otherwise difficult to access, along with ...
Chen‐Yan Cai, Yuzuru Kanda, Tian Qin
wiley   +2 more sources

Silver Benzoate Facilitates the Copper-Catalyzed C-N Coupling of Iodoazoles with Aromatic Nitrogen Heterocycles. [PDF]

ACS Omega, 2021
Lozano C, Ramirez C, Sin N, Viart HM, Prusiner SB, Paras NA, Conrad J.   +6 more
europepmc   +1 more source

Azole γ‐Peptides Helix Switching via Heterocycle Substitutions

Angewandte Chemie, EarlyView.
Heterocycle substitution in azole‐based γ‐amino acids enables control over the helical shape of heterocyclic γ‐peptides. S↔N permutation in thiazole residues switches a canonical 9‐helix into a flexible helix exhibiting discontinuous hydrogen bonding.
Samantha Chaise, Claude Didierjean, Audrey Gacogne, Maxime Fillaudeau, Young Kee Kang, Aurélien Lebrun, Jean‐Louis Bantignies, Dominique Housset, Muriel Amblard, Ludovic T. Maillard, Baptiste Legrand   +10 more
wiley   +2 more sources