Results 121 to 130 of about 871,548 (248)

Polar Heterobenzylic C(sp³)-H Chlorination Pathway Enabling Efficient Diversification of Aromatic Nitrogen Heterocycles. [PDF]

J Am Chem Soc, 2023
Maity S, Lopez MA, Bates DM, Lin S, Krska SW, Stahl SS.   +5 more
europepmc   +1 more source

Biosynthesis and Genetic Tuning of Guanine Crystals via Metabolic Engineering of Yeast

Angewandte Chemie, EarlyView.
We demonstrate how yeast cells can be harnessed as cellular factories for the synthesis of optically functional guanine crystals, where genetic editing is used to tune crystal size, order and optical properties. This demonstrates a powerful new biosynthetic approach for the development of sustainable and biocompatible optical pigments, which utilizes ...
Jerome N. Janssen, Yahel Fishman, Yi Li, Avital Wagner, Mariela J. Pavan, Zohar Paleiov, Tali Lemcoff, Rotem Lichtenstein‐Wolfheim, Alexander Upcher, Einat Nativ‐Roth, Amir Aharoni, Benjamin A. Palmer   +11 more
wiley   +2 more sources

Decoration of A-Ring of a Lupane-Type Triterpenoid with Different Oxygen and Nitrogen Heterocycles. [PDF]

Molecules, 2022
Sousa JLC, Albuquerque HMT, Silvestre AJD, Silva AMS.   +3 more
europepmc   +1 more source

Copper-Catalyzed Direct alpha-Peroxidation of Nitrogen Heterocycles

Functionalized, saturated nitrogen heterocycles form the core structures of many molecules that have an impact on our daily lives, including natural products and pharmaceuticals.
Gerard, Phideline, Guissart, Céline, Evano, Gwilherm   +2 more
core   +1 more source

Methylene Insertion into Nitrogen‐Heteroatom Single Bonds of 1,2‐Azoles via a Zinc Carbenoid: An Alternative Tool for Skeletal Editing

Advanced Science
The nitrogen‐heteroatom single bonds of 1,2‐azoles and isoxazolines underwent methylene insertion in the presence of CH2I2 (6 equiv.) and diethylzinc (3 equiv.) to produce a wide variety of the ring‐expanded six‐membered heterocycles.
Masato Tsuda, Taiki Morita, Yuto Morita, Jun Takaya, Hiroyuki Nakamura   +4 more
doaj   +1 more source

Structural diversity using amino acid "Customizable Units": conversion of hydroxyproline (Hyp) into nitrogen heterocycles. [PDF]

Amino Acids, 2022
Hernández D, Porras M, Boto A.
europepmc   +1 more source

Synthesis of bridgehead nitrogen heterocycles

, 1980
Reductive cyclizations of N ‐[2‐(2‐pyridyl)ethyl]imides were accomplished by employing a palladium on carbon catalyst in ethanolic acetic acid as the hydrogenation medium.
Burckhalter, Joseph H., Scovill, John P.
core   +1 more source

Flavin Catalysts in Organic Synthesis

Angewandte Chemie, EarlyView.
Flavins and their congeners are potent catalysts for organic synthesis inspired by enzymatic transformations. In addition to catalysis in the flavin ground state via covalent intermediates, the excited singlet and triplet states unlock applications including photooxidation, photoreduction, and energy transfer via sensitization.
Jan Freudenberg, Golo Storch
wiley   +2 more sources

Polycyclic nitrogen heterocycles as potential thymidine phosphorylase inhibitors: synthesis, biological evaluation, and molecular docking study. [PDF]

J Enzyme Inhib Med Chem, 2022
Aknin K, Bontemps A, Farce A, Merlet E, Belmont P, Helissey P, Chavatte P, Sari MA, Giorgi-Renault S, Desbène-Finck S.   +9 more
europepmc   +1 more source

Deprotonation and Alkylation of Weakly Acidic C(sp3)─H Bonds Through In Situ Generation of a Strong Hydride Base From 1,1,3,3‐Tetramethyldisiloxane and Potassium tert‐Butoxide

Angewandte Chemie, EarlyView.
The use of 1,1,3,3‐tetramethyldisiloxane (TMDSO) and potassium tert‐butoxide enables direct alkylation of weakly acidic carbon–hydrogen bonds with alkyl halides. Experimental and computational studies support the formation of a substrate‐associated hydride‐like base, providing a single‐step alternative to the classical deprotonation and electrophile ...
Piers St. Onge, Brandon White, Han Yao, Travis Dudding, Stephen G. Newman   +4 more
wiley   +2 more sources