Results 121 to 130 of about 1,403,091 (264)

π‐Extended COUPY Fluorophores for Targeted Near‐Infrared Fluorescence and Lifetime Imaging in Live Cells

Angewandte Chemie, EarlyView.
π‐Extended COUPY dyes, obtained by vinylogation of coumarin‐based COUPY scaffolds, shift absorption, and emission deep into the NIR region while preserving compactness and synthetic accessibility. These bright, photostable dyes enable live‐cell imaging, FLIM, and site‐specific peptide conjugation, offering a modular platform for targeted bioimaging and
Diego Abad‐Montero, Manel Bosch, Rodrigo Garcés‐Castellanos, Michael Q. Schottenhamel, Sergio Pedraza‐Arevalo, Alejandro Ibáñez‐Costa, Justo P. Castaño, Tania García‐Becerra, Elena Rebollo, Marta E. Alberto, Antonio Francés‐Monerris, Vicente Marchán   +11 more
wiley   +2 more sources

A Comprehensive 19F NMR Framework for Fragment‐Based Drug Discovery: The Validated Screening Library OpenFL600 and Efficient Affinity Ranking by CSAR

Angewandte Chemie, EarlyView.
NMR screening is a powerful method for hit detection in drug‐discovery. We designed and validated the OpenFL600 19F$^{19}{\rm F}$ NMR library to probe diverse targets, including RNA, GPCRs, kinases, and proteases. This library yields target‐specific ligands without generating promiscuous binders.
Simon H. Rüdisser, Gabriela Stadler, Giacomo Padroni, Daria Barbash, Marco M. Ruckstuhl, Nils Lorz, Christina Jordan, Sarah Skibinski, Timo T. Stühlinger, Sarah E. Kratzwald, Katharina M. Siess, Sven Brüschweiler, Gerald Platzer, Antoine Cléry, Robert Konrat, Frédéric H.‐.T. Allain, Alvar D. Gossert   +16 more
wiley   +2 more sources

Energetic and Geometric Characteristics of the Substituents: Part 2: The Case of NO₂, Cl, and NH₂ Groups in Their Mono-Substituted Derivatives of Simple Nitrogen Heterocycles. [PDF]

Molecules, 2021
Wieczorkiewicz PA, Szatylowicz H, Krygowski TM.   +2 more
europepmc   +1 more source

Visible‐Light‐Induced Hydrogen Generation from Mixtures of Hydrogen Boride Nanosheets and Phenanthroline Molecules

Advanced Science
Hydrogen boride (HB) nanosheets are recognized as a safe and lightweight hydrogen carrier, yet their hydrogen (H2) generation technique has been limited.
Jumpei Takeshita, Hayato Tsurugi, Andi Mauliana, Akira Yamaguchi, Takahiro Kondo, Masahiro Miyauchi   +5 more
doaj   +1 more source

An unusual formal migrative cycloaddition of aurone-derived azadienes: synthesis of benzofuran-fused nitrogen heterocycles. [PDF]

Chem Sci, 2021
Feng Q, Wu A, Zhang X, Song L, Sun J.
europepmc   +1 more source

Biological and Teratogenic Evaluations of Nitrogen Heterocycles for Anticancer Therapy. [PDF]

Pharmaceuticals (Basel)
Dos Santos JC, Alves JEF, de Azevedo RDS, da Silva JG, Silva MRO, da Silva LPBG, Soares CVS, da Silva JM, da Silva NF, de Oliveira JF, de Lima MDCA, Moura RO, de Almeida SMV.   +12 more
europepmc   +1 more source

Double Ionization of Polycyclic Aromatic Nitrogen Heterocycles: Simulations on Phenanthridine. [PDF]

ACS Earth Space Chem
Basilio JHC, Molpeceres G, Wolff W, Pereira-Santaella M, Oliveira RR.   +4 more
europepmc   +1 more source

Electronic Activation Enables the Borylation of Alkyl C-H Bonds in Saturated Nitrogen Heterocycles. [PDF]

J Am Chem Soc
D'Angelo KA, Zheng R, Yu IF, Tang MJ, La C, Wetterer RT, Hartwig JF.   +6 more
europepmc   +1 more source

Is Phenylnitrene a Missing Link in the Formation of Polycyclic Aromatic Nitrogen Heterocycles? [PDF]

Angew Chem Int Ed Engl
Arns R, McClish R, Hemberger P, Bodi A, Bouwman J, Kasper T, Schleier D.   +6 more
europepmc   +1 more source

Photogenerated Oxetanes as a Gateway to Uphill Cyclopropanation

Angewandte Chemie International Edition, EarlyView.
An atom‐economical route to densely functionalized cyclopropanes from furans and photochemically activated aldehydes is enabled by a unique oxetane‐to‐cyclopropane rearrangement. These cyclopropanes can be used to access complex bioactive scaffolds and serve as a platform for asymmetric cyclopropane synthesis.
Tim Köglmeier, Thomas J. Tiefel, Oliver Reiser   +2 more
wiley   +1 more source