Results 21 to 30 of about 1,413,381 (322)

Pivotal role of nitrogen heterocycles in Alzheimer's disease drug discovery.

open access: yesDrug Discovery Today, 2022
Alzheimer's disease (AD) is a detrimental neurodegenerative disease that progressively worsens with time. Clinical options are limited and only provide symptomatic relief to AD patients.
Shikha Kumari   +5 more
semanticscholar   +1 more source

Recent Advances in N-Heterocyclic Small Molecules for Synthesis and Application in Direct Fluorescence Cell Imaging

open access: yesMolecules, 2023
Nitrogen-containing heterocycles are ubiquitous in natural products and drugs. Various organic small molecules with nitrogen-containing heterocycles, such as nitrogen-containing boron compounds, cyanine, pyridine derivatives, indole derivatives ...
Yanan Li, Tao Liu, Jianan Sun
doaj   +1 more source

Recent advances in metal catalyst- and oxidant-free electrochemical C-H bond functionalization of nitrogen-containing heterocycles

open access: yesFrontiers in Chemistry, 2022
The C-H functionalization of nitrogen-containing heterocycles has emerged as a powerful strategy for the construction of carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds.
Ya-Nan Li   +4 more
doaj   +1 more source

A Review on Recent Advances in Nitrogen-Containing Molecules and Their Biological Applications

open access: yesMolecules, 2020
The analogs of nitrogen-based heterocycles occupy an exclusive position as a valuable source of therapeutic agents in medicinal chemistry. More than 75% of drugs approved by the FDA and currently available in the market are nitrogen-containing ...
Nagaraju Kerru   +4 more
doaj   +1 more source

The Role of Five-Membered Heterocycles in the Molecular Structure of Antibacterial Drugs Used in Therapy

open access: yesPharmaceutics, 2023
Five-membered heterocycles are essential structural components in various antibacterial drugs; the physicochemical properties of a five-membered heterocycle can play a crucial role in determining the biological activity of an antibacterial drug.
Aura Rusu   +3 more
doaj   +1 more source

Fused 1,5-Naphthyridines: Synthetic Tools and Applications

open access: yesMolecules, 2020
Heterocyclic nitrogen compounds, including fused 1,5-naphthyridines, have versatile applications in the fields of synthetic organic chemistry and play an important role in the field of medicinal chemistry, as many of them have a wide range of biological ...
Carme Masdeu   +6 more
doaj   +1 more source

An electron-deficient triosmium cluster containing the thianthrene ligand: Synthesis, structure and reactivity of [Os₃(CO)₉(μ3-η2-C₁₂H₇S₂)(μ-H)] [PDF]

open access: yes, 2008
Reaction of [Os₃(CO)₁₀(CH₃CN)₂] with thianthrene at 80 °C leads to the nonacarbonyl dihydride compound [Os₃(CO)₉(μ-3,4-η²-C₁₂H₆S₂)(μ-H)₂] (1) and the 46-electron monohydride compound [Os₃(CO)₉(μ₃-η²-C₁₂H₇S₂)(μ-H)] (2).
Hassan, Mohammad R.   +7 more
core   +1 more source

Nitrogen heterocycles from trimethylbenzenes

open access: yesHeteroatom Chemistry, 2004
AbstractThe reaction between 1,2,4‐trimethylbenzene 1, isobutyric aldehyde, and cyanoacetic ester afforded a mixture of three products: 3,3,5,6,8‐ pentamethyl‐1,2,3,4‐tetraisoquinolylidene‐1‐acetic acid ether (2) and its 3,3,5,6,7‐pentamethyl‐(3)‐ and 3,3,6,7,8‐pentamethyl‐1,2,3,4‐tetraisoquinolyli‐ dene‐1‐acetic acid ether isomers (3) in ratio 1:5:1. ©
Yu. V. Shklyaev   +6 more
openaire   +1 more source

Development of covalent triazine frameworks as heterogeneous catalytic supports [PDF]

open access: yes, 2019
Covalent triazine frameworks (CTFs) are established as an emerging class of porous organic polymers with remarkable features such as large surface area and permanent porosity, high thermal and chemical stability, and convenient functionalization that ...
Krishnaraj, Chidharth   +3 more
core   +1 more source

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