Results 141 to 150 of about 8,002 (167)
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Pharmacokinetics of Nitroimidazoles
1982In this paper I want to try and show how a knowledge of the metabolism and pharmacokinetics of a compound helps us to understand the reasons why it may or may not satisfy the criteria desired of a particular drug. How we want a drug to behave depends on the use we have in mind for it. For example, in Fig.
T. R. Marten +3 more
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On the mutagenicity of nitroimidazoles
Mutation Research/Reviews in Genetic Toxicology, 1981Regarding mutagenicity, metronidazole is one of the best-investigated compounds of the nitroimidazoles. This drug is mutagenic on bacteria, especially if base-pair tester strains are used and bacterial nitroreductases are present. The serum levels attained in man after intake of this drug are sufficient to cause mutations in bacteria.
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Modification of chemotherapy by nitroimidazoles
International Journal of Radiation Oncology*Biology*Physics, 1984The potentiation of chemotherapeutic agents by radiation sensitizers has been extensively studied for several years. There is little doubt that the effectiveness of certain anti-cancer drugs, primarily alkylating agents, can readily be enhanced both in vitro and in vivo through the addition of a sensitizer.
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Antiparasitic nitroimidazoles. 1. 2-Styryl-5-nitroimidazoles
Journal of Medicinal Chemistry, 1972W J, Ross, W B, Jamieson, M C, McCowen
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Scandinavian journal of infectious diseases. Supplementum, 1986
The nitroimidazoles used in the treatment of anaerobic infection are well-tolerated by patients. With the possible exception of neurotoxic effects associated with high dosage, signs and symptoms of toxicity are transient and disappear soon after withdrawal of treatment.
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The nitroimidazoles used in the treatment of anaerobic infection are well-tolerated by patients. With the possible exception of neurotoxic effects associated with high dosage, signs and symptoms of toxicity are transient and disappear soon after withdrawal of treatment.
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Studies on the action of nitroimidazole drugs. The products of nitroimidazole reduction.
Biochemical pharmacology, 1983The electron requirements for the electrolytic reduction of misonidazole, metronidazole and 4(5)-nitroimidazole have been measured using high-resolution coulometry. Eleven of the labelled final reduction products of metronidazole (a 5-nitroimidazole) have been separated by high-performance liquid chromatography and identified. These appear to be formed
R J, Knox, R C, Knight, D I, Edwards
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Bacteroides fragilis and nitroimidazoles
Journal of Antimicrobial Chemotherapy, 1976I R, Ferguson, L L, Smith
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