Results 61 to 70 of about 8,282 (214)

Synthesis of New Active Sulfones in the 5-Nitroimidazole Series

Molecules, 2002
We describe here the preparation of new 5-nitroimidazoles which are known to have an efficacy against metronidazole-susceptible and -resistant Giarda, Trichomonas, and Entamoeba spp. The multi-step synthesis uses electron transfer methodology.
Patrice Vanelle, Thierry Terme, Kamel Benakli   +2 more
doaj   +1 more source

Pharmacokinetics-pharmacodynamics analysis of bicyclic 4-nitroimidazole analogs in a murine model of tuberculosis. [PDF]

PLoS ONE, 2014
PA-824 is a bicyclic 4-nitroimidazole, currently in phase II clinical trials for the treatment of tuberculosis. Dose fractionation pharmacokinetic-pharmacodynamic studies in mice indicated that the driver of PA-824 in vivo efficacy is the time during ...
Suresh B Lakshminarayana, Helena I M Boshoff, Joseph Cherian, Sindhu Ravindran, Anne Goh, Jan Jiricek, Mahesh Nanjundappa, Amit Nayyar, Meera Gurumurthy, Ramandeep Singh, Thomas Dick, Francesca Blasco, Clifton E Barry, Paul C Ho, Ujjini H Manjunatha   +14 more
doaj   +1 more source

Genotoxicity profile of fexinidazole—a drug candidate in clinical development for human African trypanomiasis (sleeping sickness) [PDF]

, 2017
The parasitic disease human African trypanomiasis (HAT), also known as sleeping sickness, is a highly neglected fatal condition endemic in sub-Saharan Africa, which is poorly treated with medicines that are toxic, no longer effective or very difficult to
Bourdin Trunz, Bernadette, Torreele, Els, Tweats, David   +2 more
core  

Comparison of the voltammetric behavior of metronidazole at a DNA-modified glassy carbon electrode, a mercury thin film electrode and a glassy carbon electrode [PDF]

, 1997
The electroanalytical performance at three electrodes: DNA-modified galssy carbon electrode, mercury thin film electrode and glassy carbon electrode, for the study of the electrochemical reduction of metronidazole is compared. All three electrodes showed
Brett, Ana Maria Oliveira, Gutz, Ivano G. R., La-Scalea, Mauro A., Serrano, Sílvia H. P.   +3 more
core   +1 more source

Two 1-substituted 4-nitroimidazoles

Acta Crystallographica Section C Crystal Structure Communications, 2001
Crystalline 4-nitro-1-phenylimidazole, C9H7N3O2, (I), and 4'-nitro-1-phenyl-4,1'-biiimidazole, C12H9N5O2, (II), contain C-H...O and C-H...N hydrogen bonds, connecting the molecules into infinite chains. The aromatic fragments in both compounds are nearly planar.
Kubicki, Maciej, Borowiak, Teresa, Suwinski, Jerzy, Wagner, Pawel   +3 more
openaire   +3 more sources

Core Shell Investigation of 2-nitroimidazole [PDF]

Frontiers in Chemistry, 2019
Tunability and selectivity of synchrotron radiation have been used to study the excitation and ionization of 2-nitroimidazole at the C, N, and O K-edges. The combination of a set of different measurements (X-ray photoelectron spectroscopy, near-edge photoabsorption spectroscopy, Resonant Auger electron spectroscopy, and mass spectrometry) and ...
Paola Bolognesi, Vincenzo Carravetta, Luca Sementa, Giovanni Barcaro, Susanna Monti, Preeti Manjari Mishra, Antonella Cartoni, Antonella Cartoni, Mattea C. Castrovilli, Jacopo Chiarinelli, Jacopo Chiarinelli, Sanja Tosic, Bratislav P. Marinkovic, Robert Richter, Lorenzo Avaldi   +14 more
openaire   +6 more sources

Review Article: Classic Bismuth Quadruple Therapy for Helicobacter pylori Infection—Questions Focused on Clinical Practice

Alimentary Pharmacology &Therapeutics, EarlyView.
BQT remains the most effective, safe, and practical regimen for H. pylori eradication, ensuring high cure rates across diverse resistance patterns and clinical settings. ABSTRACT Background Classic bismuth quadruple therapy (BQT)—the combination of a proton pump inhibitor, bismuth, tetracycline, and metronidazole—is a standard regimen for treating ...
Javier P. Gisbert, Pablo Parra, Olga P. Nyssen   +2 more
wiley   +1 more source

Confirmatory Analysis of Nitroimidazoles and Hydroxy Metabolites in Honey by Dispersive-Solid Phase Extraction and Ultra-High Performance Liquid Chromatography-Tandem Mass Spectrometry

Molecules, 2018
An ultra-high performance liquid chromatography-tandem quadrupole mass spectrometry (UHPLC-MS/MS) method was developed and validated for confirmatory analysis of four nitroimidazoles and three hydroxy metabolites in honey. Honey samples were dissolved in
Xiaowei Li, Yuebin Ke, Yingyu Wang, Chengfei Wang, Dongyang Ye, Xue Hu, Lan Zhou, Xi Xia   +7 more
doaj   +1 more source

Optimum Treatment Regimens for Helicobacter Pylori Infection [PDF]

, 2000
The treatment of Helicobacter pylori infection includes of current standard triple therapies consisting of a proton pump inhibitor, clarithromycin and amoxicillin or metronidazole on the basis of simplicity, safety, and efficacy.
Hunt, R. H. (Richard)
core   +1 more source

Antimicrobial peptides as novel anti-tuberculosis therapeutics [PDF]

, 2016
"Available online 24 May 2016"Tuberculosis (TB), a disease caused by the human pathogen Mycobacterium tuberculosis, has recently joined HIV/AIDS as the world's deadliest infectious disease, affecting around 9.6 million people worldwide in 2014. Of those,
Agerberth, Ahsan, Andersson, Andersson, Andries, Aoki, Asaduzzaman, Balasubramanian, Bartolomeo, Bauer, Bayer, Bell, Bierbaum, Blaas, Bogatcheva, Bottger, Bray, Brogden, Brown, Brötz, Butler, Carroll, Center for Drug Evaluation and Research (CDER), Cervantes-Villagrana, Champion, Champion, Ciornei, Cohen, Corrales-Garcia, Courvalin, Diel, Directorate-General of the European Comission, Duplantier, Durr, Eckert, Ernst, European Commission, European Commission, European Commission, European Medicines Agency, Fattorini, Florence, Food and Drug Administration (FDA), Food and Drug Administration (FDA), Fox, Fox, Fox, Francisco Miguel Gama, Fratti, Fuertes, Gaspar, Gelperina, Ghobrial, Giehl, Giuliani, Gler, Global Alliance for TB Drug Development, Global Drug Facility, Goldstein, Gottler, Guirado, Gunther, Hancock, Hancock, Harper, Harris, Hmama, Horn, Hunter, International Conference on Harmonizarion Expert Working Group, Ishizaki, Islam, Jarlier, Jena, Jiang, Jin, João P. Silva, Kalita, Kaplan, Kapoor, Kaspar, Kayser, Khara, Kik, Kisich, Kusnadi, Kwok, Lan, Lax, Lax, Lee, Lee, Lehrer, Levy, Li, Li, Li, Limoli, Linde, Lunov, Makarov, Mansour, Mariappan, Marr, Matsuzaki, Matsuzaki, McGhan, Miller-Keane, Mily, Miteva, Mohanty, Molhoek, Mukherjee, Mygind, Médecins sans Frontières (MSF), Nagaoka, Nawrocki, Neyrolles, Nikonenko, Nizet, Nizet, Onyebujoh, Oren, Orme, Otvos, Padhi, Pandey, Pandey, Park, Patrzykat, Peschel, Peschel, Pethe, Pietiainen, Pokorny, Prideaux, Protopopova, Ramon-Garcia, Ramos, Ramos, Rathinakumar, Rivas-Santiago, Rivas-Santiago, Rivas-Santiago, Rosenfeld, Roy, Rubinchik, Rui Appelberg, Rutherfurd, Sanborn, Santos, Santos, Saravolatz, Schatz, Scheinpflug, Sensi, Shai, Shai, Sharma, Sharma, Shaw, Sherman, Shinnar, Silva, Somoskovi, Sosnik, Sosunov, Stehr, Steinstraesser, Stenger, Sterling, Sundararajan, Swietlow, Tabata, Tahlan, Tasneen, Tomioka, Toro, Torres-Juarez, Transparency Market Research, Uhlig, van der Does, Vilcheze, Vlieghe, Wallis, Wang, Wang, Welsh, Wenzel, Wiedemann, Wimley, World Health Organization, World Health Organization (WHO), World Health Organization (WHO), World Health Organization (WHO), World Health Organization (WHO), Xiong, Yamasaki, Yang, Yeaman, Zasloff, Zasloff, Zeitler, Zelezetsky, Zhang, Zhao, Zumla, Zumla, Zumla   +208 more
core   +1 more source