Results 11 to 20 of about 1,746 (206)

Novel 8-nitroquinolin-2(1H)-ones as NTR-bioactivated antikinetoplastid molecules:Synthesis, electrochemical and SAR study [PDF]

, 2018
International audienceTo study the antiparasitic 8-nitroquinolin-2(1H)-one pharmacophore, a series of 31 derivatives was synthesized in 1-5 steps and evaluated in vitro against both Leishmania infantum and Trypanosoma brucei brucei.
Azas, Nadine, Boudot, Clotilde, Bourgeade-Delmas, Sandra, Boutet-Robinet, Elisa, Courtioux, Bertrand, Fairlamb, Alan, Hutter, Sébastien, Laget, Michèle, Moreau, Alain, Mothes, Emmanuelle, Paloque, Lucie, Pedron, Julien, Pratviel, Geneviève, Sournia-Saquet, Alix, Stigliani, Jean-Luc, Valentin, Alexis, Vendier, Laure, Verhaeghe, Pierre, Wyllie, Susan   +18 more
core   +4 more sources

1-Ethyl-3-nitroquinolin-4(1H)-one [PDF]

IUCrData, 2016
The title compound, C11H10N2O3, was obtained as side-product in a project focussing on the synthesis of carbolines. It was prepared from nitroquinolinone, ethanol and phosphoryl chloride. With the exception of the methyl group [C—N—C—Cmethyltorsion angle = −96.4 (2)°], the molecule is essentially planar (r.m.s. deviation = 0.033 Å).
Daniel Limbach, Elena Stengelin, Dieter Schollmeyer, Heiner Detert   +3 more
openaire   +2 more sources

Insertion of Nanoluc into the Extracellular Loops as a Complementary Method To Establish BRET-Based Binding Assays for GPCRs [PDF]

, 2022
Luminescence-based techniques play an increasingly important role in all areas of biochemical research, including investigations on G protein-coupled receptors (GPCRs).
Bernhardt, Günther, Grätz, Lukas, Littmann, Timo, Müller, Christoph, Pegoli, Andrea, Schindler, Lisa   +5 more
core   +1 more source

Green Chemistry and Synthesis of Anticancer Molecule [PDF]

, 2017
Green chemistry is a modern area of chemistry merged with chemical engineering methods. It highlighted the synthesis of molecules in a manner of using environment-friendly chemical reagents with low waste material for enhancing environmental performance ...
Al-Taweel, Areej Mohammad, Perveen, Shagufta   +1 more
core   +1 more source

An Overview of Leishmaniasis: Historic to Future Perspectives [PDF]

, 2018
Human leishmaniasis is a major public health problem with a wide clinical spectrum. Despite there is an epidemiological diversity of the disease, cases mostly occur in the developing countries around the subtropical region, and the incidence is ...
Güran, Mümtaz
core   +1 more source

Oxidation and reduction processes for 1,10-phenanthroline derivatives and their analogs [PDF]

, 2021
Rozprawa doktorska podzielona jest na trzy części: wstęp teoretyczny, badania własne oraz część eksperymentalną. Wstęp teoretyczny podzielony jest na poszczególne rozdziały, w których opisano: otrzymywanie, zastosowanie i funkcjonalizacje pochodnych 1,10-
Wantulok, Jakub
core  

Interfacial Bioengineering of Dynamic Networks Hybrid Hydrogel for Programmed Intervention in Oral Precancerous Epithelial States

Advanced Healthcare Materials, EarlyView.
This study develops a dual‐bioinspired hydrogel, MSA@PGel (macrophage membrane‐coated and salvianolic acid B/5‐aminolevulinic acid co‐loaded liposomes embedded in a polydopamine‐based gel), that integrates macrophage membrane‐mediated active targeting and mussel‐inspired wet adhesion for programmed intervention in oral precancerous lesions.
Xiaoxian Zhao, Ao Zheng, Zhengyan Zhao, Qilin Li, Tianhao Wan, Tanjun Deng, Ying Zhang, Lingyan Cao, Lan Wu   +8 more
wiley   +1 more source

Interactions of 4-nitroquinoline 1-oxide with four deoxyribonucleotides [PDF]

Biochemistry, 1978
The interactions of 4-nitroquinoline 1-oxide (NQO) with the four 5'-deoxyribonucleotides were probed using absorption spectra of the charge transfer bands and 1H and 13C nuclear magnetic resonance (NMR) spectra of nucleotide-NQO mixtures. Spectral data yielded equilibrium constants (K(dpG:NQO) = 16 M-1, K(dpA:NQO) = 12 M-1, K(dpT:NQO) = K(dpC:NQO) = 4 ...
S A, Winkle, I, Tinoco
openaire   +2 more sources

Integrated Population Pharmacokinetic, Pharmacodynamic, and Safety Analyses to Inform Dosage Selection in the Clinical Development of the ATR Inhibitor Tuvusertib

Clinical Pharmacology &Therapeutics, EarlyView.
We present model‐informed selection of the recommended dose for expansion (RDE) of investigational oral ATR inhibitor tuvusertib, by integrating clinical pharmacokinetics (PK), pharmacodynamics (PD), and safety data from DDRiver Solid Tumors 301 trial Part A1 (NCT04170153).
Jatinder Kaur Mukker, Paul Matthias Diderichsen, Farina Hellmann, Timothy A. Yap, Ruth Plummer, Anthony W. Tolcher, Johann S. de Bono, Ioannis Gounaris, Zoltan Szucs, Astrid Zimmermann, Irina Kareva, Jayaprakasam Bolleddula, Annick Seithel‐Keuth, Giuseppe Locatelli, Marta Enderlin, Christine Hicking, Anup Zutshi, Wei Gao, Rainer Strotmann, Lisa Benincosa, Karthik Venkatakrishnan   +20 more
wiley   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source