Results 41 to 50 of about 26,472 (210)

Clinical relevance of biomarkers of oxidative stress [PDF]

, 2015
SIGNIFICANCE Oxidative stress is considered to be an important component of various diseases. A vast number of methods have been developed and used in virtually all diseases to measure the extent and nature of oxidative stress, ranging from oxidation ...
Ana Cipak Gasparovic, Annie R. Knight, Antonio Cuadrado, Awad JA, Baker JR, Broedbaek K, Daniela Weber, David Cheng, Emma Louise Taylor, Harald H.H.W. Schmidt, Henrik Enghusen Poulsen, Herzenberg LA, Holvoet P, Jeannette Oettrich, Jeroen Frijhoff, Ji L, Johnson D, Kaplowitz N, Khan J, McCord JM, Miyata T, Neven Zarkovic, Paul G. Winyard, Pietro Ghezzi, Poulsen HE, Roland Stocker, Salomon RG, Sean S. Davies, Takahashi M, Tatjana Ruskovska, Tilman Grune, WHO, Witko-Sarsat V   +32 more
core   +1 more source

Oxidative Stress in the Blood Labyrinthine Barrier in the Macula Utricle of Meniere’s Disease Patients

Frontiers in Physiology, 2018
The blood labyrinthine barrier (BLB) is critical in the maintenance of inner ear ionic and fluid homeostasis. Recent studies using imaging and histopathology demonstrate loss of integrity of the BLB in the affected inner ear of Meniere’s disease (MD ...
Gail Ishiyama, Jacob Wester, Ivan A. Lopez, Luis Beltran-Parrazal, Luis Beltran-Parrazal, Akira Ishiyama   +5 more
doaj   +1 more source

Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis [PDF]

, 2017
Aims: We questioned whether aldosterone and oxidative stress play a role in vascular damage in severe hypertension and investigated the role of Nox1 in this process.
Ceravolo, Graziela, Graham, Delyth, Harvey, Adam P., Hood, Katie Y., Lopes, Rheure A., Montezano, Augusto C., Rios, Francisco, Touyz, Rhian M.   +7 more
core   +1 more source

A panel of oxidative stress assays does not provide supplementary diagnostic information in Behcet's disease patients

Journal of Inflammation, 2012
Background Recent findings suggest a role of oxidative stress in the pathogenesis of Behcet's disease (BD), but the utility of oxidative stress-associated assays in offering diagnostic information or in the monitoring of disease activity is largely ...
Akcay Yasemin D, Sagin Ferhan G, Aksu Kenan, Keser Gokhan, Taylor Emma, Knight Iona, Winyard Paul G, Sozmen Eser Y   +7 more
doaj   +1 more source

Proteomics of Nitrotyrosine: Integrating Mass Spectrometry and Immunodetection in Redox‐Driven Pathology

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Nitrooxidative stress, driven by excess reactive nitrogen species like peroxynitrite, contributes to the pathogenesis of many chronic diseases. Among its molecular footprints, 3‐nitrotyrosine (3NT) has emerged as a biologically relevant marker of protein nitration.
Brîndușa Alina Petre
wiley   +1 more source

Decreased soluble guanylate cyclase contributes to cardiac dysfunction induced by chronic doxorubicin treatment in mice [PDF]

, 2017
Aims: The use of doxorubicin, a potent chemotherapeutic agent, is limited by cardiotoxicity. We tested the hypothesis that decreased soluble guanylate cyclase (sGC) enzyme activity contributes to the development of doxorubicin-induced cardiotoxicity ...
Allen, Kaitlin, Bartunek, Jozef, Beerens, Manu, Bloch, Donald B, Bloch, Kenneth D, Brouckaert, Peter, Buys, Emmanuel S, Caluwe, Ellen, Gillijns, Hilde, Janssens, Stefan P, Nathan, Daniel I, Scherrer-Crosbie, Marielle, Swinnen, Melissa, Tainsh, Robert E, Vandenwijngaert, Sara, Walravens, Ann-Sophie   +15 more
core   +1 more source

Nox2 dependent redox-regulation of microglial response to amyloid-β stimulation and microgliosis in aging [PDF]

, 2020
Microglia express constitutively a Nox2 enzyme that is involved in neuroinflammation by the generation of reactive oxygen species (ROS). Amyloid β (Aβ) plays a crucial role in Alzheimer’s disease.
Fan, Lampson M., Geng, Li, Li, Jian-mei, Liu, Fangfei, Smith, Colin   +4 more
core   +2 more sources

Xanthatin‐13‐(Pyrrolidine‐2‐Carboxylic Acid), a Sesquiterpene Lactone Isolated From Burdock Leaf, Attenuated Aβ25‐35 Toxicity and Memory Deficits in a Pharmacological Mouse Model of Alzheimer's Disease

Phytotherapy Research, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a severe form of dementia, which occurrence increases with age and lifestyle conditions. It is characterized by amyloid protein accumulation forming senile plaques, hyperphosphorylated tau protein forming neurofibrillary tangles, neuroinflammation, and oxidative stress, leading to synapse loss and cell death ...
Charlyne Barry‐Simonnet, Lucie Crouzier, Tristan Moujellil‐Legagneur, Hamza Chaieb‐Errass, Yanis A. Idres, Karine Ferrare, Marc Rolland, Guillaume Cazals, Patrick Poucheret, Tangui Maurice, Didier Tousch   +10 more
wiley   +1 more source

Indicators of nitrosative and oxidative stress as non-invasive markers of bacterial meningitis in preterm infants

Zdorovʹe Rebenka, 2019
Background. In oxidative and nitrosative stresses, the brain is vulnerable to oxidant damage due to high oxygen consumption, large amounts of iron, relatively low antioxidant expression, high concentration of polyunsaturated fatty acids.
G.O. Lezhenko, O.Ye. Pashkova, A.V. Abramov, L.O. Volotko   +3 more
doaj   +1 more source

iNitroY-Deep: Computational Identification of Nitrotyrosine Sites to Supplement Carcinogenesis Studies Using Deep Learning

IEEE Access, 2021
In biological systems, Nitration is a crucial post-translational modification which occurs on various amino acids. Nitration of Tyrosine is regarded as nitorsative stress biomarker resulting in the formation of peroxynitrite and other reactive and ...
Sheraz Naseer, Rao Faizan Ali, Suliman Mohamed Fati, Amgad Muneer   +3 more
doaj   +1 more source