Results 161 to 170 of about 3,155 (190)

Expression of Different Neurokinin-1 Receptor (NK1R) Isoforms in Glioblastoma Multiforme: Potential Implications for Targeted Therapy

Cancer Biotherapy and Radiopharmaceuticals, 2014
In clinical trials, overexpression of neurokinin-1 receptors (NK1R) in gliomas has been exploited by intratumoral injection of its radiolabeled ligand, substance P (SP).
Luigi Mariani, Thomas L. Mindt, Gregor Hutter   +2 more
exaly   +2 more sources

NK1R Antagonist Decreases Inflammation and Metastasis of Breast Carcinoma Cells Metastasized to Liver but Not to Brain; Phenotype-Dependent Therapeutic and Toxic Consequences

Cancer Immunology, Immunotherapy, 2020
Substance P a neuro-immune mediator acts on Neurokinin-1 and -2 receptors (NK1R and NK2R). Inhibitors of NK1R are considered to be safe and effective approaches for cancer treatment since Aprepitant, a non-peptide antagonist of NK1R is widely used for ...
Nuray Erin, Sadi Köksoy, Esra Nizam
exaly   +2 more sources

Antagonism of L-Type Cav Channels With Nifedipine Differentially Affects Performance of Wildtype and NK1R−/− Mice in the 5-Choice Serial Reaction-Time Task

Neuropharmacology, 2013
Mice with functional ablation of the substance P-preferring receptor gene ('Nk1r' in mice ('NK1R-/-'), 'TACR1' in humans) display deficits in cognitive performance that resemble those seen in patients with Attention Deficit Hyperactivity Disorder (ADHD):
Stephen P Hunt, David N Stephens, S Clare Stanford   +2 more
exaly   +1 more source

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Potential in vitro therapeutic effects of targeting SP/NK1R system in cervical cancer

Molecular Biology Reports, 2021
Cervical cancer, an aggressive gynecological cancer, seriously threatens women's health worldwide. It is recently reported that neuropeptide substance P (SP) regulates many tumor-associated processes through neurokinin-1 receptor (NK1R). Therefore, we used cervical cancer cell line (HeLa) to investigate the functional relevance of the SP/NK1R system in
Mahtab Mozafari, Safieh Ebrahimi, Reza Assaran Darban, Seyed Isaac Hashemy   +3 more
openaire   +2 more sources

The redox modulatory effects of SP/NK1R system: Implications for oxidative stress-associated disorders

Life Sciences, 2022
Oxidative stress which refers to redox imbalance with increased generation of reactive oxygen species (ROS) has been associated with the pathophysiology of diverse disease conditions. Recently, a close, yet not fully understood, relation between oxidative stress and neuropeptides, in particular, substance P (SP), has been reported in certain conditions.
Safieh Ebrahimi, Abbas Alalikhan, Seyed Hamid Aghaee-Bakhtiari, Seyed Isaac Hashemy   +3 more
openaire   +2 more sources

Localization of neurokinin 1 receptor (NK1R) immunoreactivity in rat esophagus

Journal of Comparative Neurology, 2004
AbstractThe aim of the present immunohistochemical study was to investigate the localization of neurokinin 1 receptor (NK1R) in rat esophagus and examine the relationship between NK1Rs and intrinsic cholinergic, nitrergic, or substance P (SP) neurons. NK1R immunoreactivity (IR) was observed on the nerve cell bodies in the myenteric ganglia throughout ...
Hirofumi, Kuramoto, Yukio, Oomori, Hiroshi, Murabayashi, Makoto, Kadowaki, Shin-Ichiro, Karaki, Atsukazu, Kuwahara   +5 more
openaire   +2 more sources

TGFβ regulates NK1R-Tr to affect the proliferation and apoptosis of breast cancer cells

Life Sciences, 2020
TGFβ promotes cancer aggressiveness in advanced stages. NK1R-Tr expression in advanced breast cancer has a pro-carcinogenic effect. In this study, we aimed to investigate the effect of the association of TGFβ with NK1R-Tr expression on the proliferation and apoptosis of breast cancer cells.Immunohistochemical staining and Western blot analysis were ...
Lushan, Wang, Ning, Wang, Runshi, Zhang, Dong, Dong, Rui, Liu, Lufang, Zhang, Wei, Ji, Man, Yu, Fei, Zhang, Ruifang, Niu, Yunli, Zhou   +10 more
openaire   +2 more sources

It takes your breath away – NK1R ablation in the pre-Bötzinger complex

Trends in Neurosciences, 2001
To a large extent, you owe the fact that you are alive to a small part of the ventral medulla oblongata. This region contains some of the neurons controlling respiration, intermingled with others that are thought to be involved in the control of blood pressure and heart rate.
J, Deuchars, S A, Deuchars
openaire   +2 more sources

Tropisetron attenuates lipopolysaccharide induced neuroinflammation by inhibiting NF-κB and SP/NK1R signaling pathway

Journal of Neuroimmunology, 2018
Tropisetron, an antagonist of serotonin type 3 receptors (5-HT3Rs), has been investigated in colonic inflammatory process. Since substance P/neurokinin 1 receptor (SP/NK1R) signaling pathway plays a key role in several sensory neuronal inflammatory. We evaluated the anti-inflammatory activity of tropisetron in mice cerebral cortex, and discovered that ...
Yan, Yu, Wanhu, Zhu, Qing, Liang, Jing, Liu, Xu, Yang, Guangchun, Sun   +5 more
openaire   +2 more sources

Abstract Thu135: The NK1R is Protective Against Adverse Cardiac Remodeling in a Model of Hypertension

Circulation Research
The neuropeptide substance P (SP) induces pro- and anti-fibrotic responses in the heart. Canonically, SP activates the neurokinin 1 receptor (NK1R), encoded by the Tacr1 gene. In the diabetic heart, SP is anti-fibrotic and treatment with the NK1R agonist, GR73632, normalizes fibrosis and cardiac dysfunction ...
Kallie Schafner, Heather Connery, Alexander Widiapradja, Scott Levick   +3 more
openaire   +1 more source