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Best Practice & Research Clinical Haematology, 2019
NK/T-cell lymphomas are extranodal EBV-related malignancies, mostly of NK-cell and occasionally of T-cell lineage. They are divided into nasal, non-nasal, and disseminated subtypes. Nasal NK/T-cell lymphomas involve the nose, nasopharynx and the upper aerodigestive tract.
Eric, Tse, Yok-Lam, Kwong
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NK/T-cell lymphomas are extranodal EBV-related malignancies, mostly of NK-cell and occasionally of T-cell lineage. They are divided into nasal, non-nasal, and disseminated subtypes. Nasal NK/T-cell lymphomas involve the nose, nasopharynx and the upper aerodigestive tract.
Eric, Tse, Yok-Lam, Kwong
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Immunology & Cell Biology, 1999
Natural killer (NK) cells are a cell of the innate immune system that play an important role in the early response to viral infections and tumours. Natural killer cells are cytolytic, and secrete cytokines that influence the developing antigen‐specific immune response.
H S, Warren, M J, Smyth
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Natural killer (NK) cells are a cell of the innate immune system that play an important role in the early response to viral infections and tumours. Natural killer cells are cytolytic, and secrete cytokines that influence the developing antigen‐specific immune response.
H S, Warren, M J, Smyth
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Developmental & Comparative Immunology, 2013
Natural killer cells are innate immune cells that destroy virally infected or transformed cells. They recognize these altered cells by a plethora of diverse receptors and thereby differ from other lymphocytes that use clonally distributed antigen receptors.
Straub, C. +7 more
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Natural killer cells are innate immune cells that destroy virally infected or transformed cells. They recognize these altered cells by a plethora of diverse receptors and thereby differ from other lymphocytes that use clonally distributed antigen receptors.
Straub, C. +7 more
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Transplant Immunology, 2002
The requirement for cytotoxic T lymphocytes during allograft rejection is controversial. We have demonstrated that CD8+ T cells are not essential for allograft rejection or for the induction of apoptosis in two experimental models of transplantation. To determine candidate cells types which may play a role in the events leading to graft rejection, the ...
Christine L, Hsieh +4 more
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The requirement for cytotoxic T lymphocytes during allograft rejection is controversial. We have demonstrated that CD8+ T cells are not essential for allograft rejection or for the induction of apoptosis in two experimental models of transplantation. To determine candidate cells types which may play a role in the events leading to graft rejection, the ...
Christine L, Hsieh +4 more
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Blood, 2010
In this issue of Blood , Baessler and colleagues find that the engagement of CD137 on mouse and human NK cells had opposite effects in that CD137 functioned as an inhibitory receptor in human NK cells and as a stimulatory receptor in mice.[1][1] As NK cells emerge as potential therapeutic ...
Jacqueline, Marvel, Thierry, Walzer
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In this issue of Blood , Baessler and colleagues find that the engagement of CD137 on mouse and human NK cells had opposite effects in that CD137 functioned as an inhibitory receptor in human NK cells and as a stimulatory receptor in mice.[1][1] As NK cells emerge as potential therapeutic ...
Jacqueline, Marvel, Thierry, Walzer
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Immunology Today, 2000
Abstract Natural killer (NK) cells have often been regarded as somewhat ‘primitive' and ‘nonspecific'; however, new data have revealed an unexpected complexity and a sophisticated capability of detecting potentially dangerous cells.
L, Moretta +4 more
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Abstract Natural killer (NK) cells have often been regarded as somewhat ‘primitive' and ‘nonspecific'; however, new data have revealed an unexpected complexity and a sophisticated capability of detecting potentially dangerous cells.
L, Moretta +4 more
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Cytokine & Growth Factor Reviews, 2015
The role of Natural Killer cells in host defense against infections as well as in tumour surveillance has been widely appreciated for a number of years. Upon recognition of "altered" cells, NK cells release the content of cytolytic granules, leading to the death of target cells.
PAOLINI, Rossella +3 more
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The role of Natural Killer cells in host defense against infections as well as in tumour surveillance has been widely appreciated for a number of years. Upon recognition of "altered" cells, NK cells release the content of cytolytic granules, leading to the death of target cells.
PAOLINI, Rossella +3 more
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Current Pharmaceutical Design, 2002
NK cells have been associated with immune surveillance of tumor cells and defense mechanisms against various pathogens. However, by their capacity for immunoregulation NK cells may also play a role in determining the response to allergens. The novel possibility that NK cell activity may in part decide development of allergic airway inflammation and ...
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NK cells have been associated with immune surveillance of tumor cells and defense mechanisms against various pathogens. However, by their capacity for immunoregulation NK cells may also play a role in determining the response to allergens. The novel possibility that NK cell activity may in part decide development of allergic airway inflammation and ...
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Zoledronate activates NK cells
Blood, 2011In this issue of Blood , Nussbaumer et al demonstrate that the bisphosphonate zoledronic acid (zoledronate), a US FDA-approved drug for the prevention of osteoporosis and treatment of bone metastases in multiple myeloma and other cancers,[1][1] can enhance IFN-γ production by IL-2–primed ...
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Nonclassical NK cell education
Nature Immunology, 2012Diseased host cells are eliminated more effectively when natural killer cells grow up in the presence of classical major histocompatibility complex (MHC) class I molecules. The nonclassical MHC class I molecule H2-M3 can exert an analogous effect.
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