Results 191 to 200 of about 314,994 (315)

Immunologic Combinations in Multiple Myeloma: Synergistic Stimulation with T cells and NK cells. [PDF]

Int J Biol Sci
Liu Z, Lai J, Yang C, Liu H, Ding K, Song J, Fu R.   +6 more
europepmc   +1 more source

Melatonin Alleviates Graft Biliary Fibrosis by Inhibiting VIM+ Cholangiocyte Subcluster via Hypoxia/TGF‐β‐CREM‐VIM Axis

Advanced Science, EarlyView.
Single‐cell RNA sequencing verified the presence of the VIM+ biliary epithelial cell (BEC) in the bile ducts of NAS patients. The hypoxia/TGF‐β‐CREM‐VIM axis mediated phenotypic switch toward VIM+ BEC is validated using a hypoxia/TGF‐β‐stimulated cellular model, a rat liver transplantation model, BEC‐specific Crem conditional knockout rats, and BEC ...
Zhaoyi Wu, Nengsheng Fu, Zhongxin Huang, Yu Mou, Ensi Ma, Xiaoshi Wang, Tian Dong, Yujun Zhang, Danqing Liu, Di Jiang, Jingya Kuang, Rui Liao, Yifeng Tao, Leida Zhang, Chengcheng Zhang   +14 more
wiley   +1 more source

IFN-γ+ NK cells as a potential predictor of pregnancy loss in unexplained recurrent pregnancy loss. [PDF]

Int J Med Sci
Yan N, Lee P, Jie H, Long L, Fu Y, Zhou C, Yuan Y.   +6 more
europepmc   +1 more source

stMixer for Scalable Mosaic Integration and Label Transfer in Spatial Histology and Multi‐Omics

Advanced Science, EarlyView.
stMixer is an unsupervised framework for scalable integration and label transfer across spatial histology and multi‐slide multi‐omics data with incomplete modality overlap. It combines self‐looped cross‐attention, multimodal metric learning, and graph‐guided cluster voting to align heterogeneous sections, correct batch effects, and propagate ...
Qixing Yang, Yan Wang, Luonan Chen, Chunman Zuo   +3 more
wiley   +1 more source

NK cells promote cardiac cell death and regulate myelopoiesis in myocardial infarction. [PDF]

Nat Commun
Cohen R, Duval V, Al-Rifai R, Maryam S, Santos-Zas I, Braik R, Diedisheim M, Jouve C, Nicoletti S, Thietart S, Guyon T, Chetrit L, Kral M, Döring Y, Weber C, Loupy A, Domenge O, Livrozet M, Hulot JS, Sakalli ET, Rizzo G, Saliba AE, Piollet M, Bruneval P, Tedgui A, Taleb S, Hermine O, Wicks I, Silvestre JS, Hayat S, Cochain C, Vivier E, Ait-Oufella H.   +32 more
europepmc   +1 more source

Tumor‐Specific Delivery of CD28 siRNA via Lyso‐PC C‐16 Modified Lipid Nanoparticles Overcomes Anti‐PD‐1 Resistance by Remodeling Tumor Microenvironment

Advanced Science, EarlyView.
This study develops 16:0 LPC‐modified lipid nanoparticles (LPC‐LNPs) with cancer cell specificity by exploiting altered tumor lipid metabolism. LPC‐LNPs encapsulating Cd28 small interfering RNA (LPC‐LNP‐Cd28) knock down cancer cell CD28 without affecting T cells, inflame the tumor microenvironment, and overcome anti‐PD‐1 resistance.
Yangyang Chai, Keyu Wang, Jiali Fang, Shaorui Jia, Yansong Shi, Wanfeng Gao, Xinpeng Liu, Jiaqiang Li, Zenghui Cui, Yazhi Qian, Xiaosu Chen, Dan Ding, Xuetao Cao   +12 more
wiley   +1 more source

BaEV-pseudotyped lentiviral vectors enable stable CAR expression and cytotoxic function in NK cells. [PDF]

PLoS One
Park M, Lim Y, Jo Y, Jo DH, Kim SK, Kim HY, Lee SH, Lee M, Cho D.   +8 more
europepmc   +1 more source

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

Anti-CD94-induced expansion of highly functional adaptive NKG2C+NKG2A−CD57+selfKIR+ NK cells from CMV-seropositive healthy donors

Human Natural Killer (NK) cells are innate lymphocytes, short-living and providing rapid responses against viral infections and tumors. Adaptive NK cells are an NK cell subpopulation arising upon cytomegalovirus (CMV) infection, characterized by the ...
Della Chiesa M., Carlomagno S., Falco M., Caruana I., Cantoni C., Muccio L., Vitale M., Giordano C., Sivori S.   +8 more
core  

Editorial: Novel chimeric antigen receptor (CAR) designs in engineering NK cells for cancer. [PDF]

Front Immunol
Chan WK.
europepmc   +1 more source