Results 241 to 250 of about 582,983 (289)

Scalable production process development for NK cells targeting large-scale expansion. [PDF]

Regen Ther
Kikuchi T, Takeuchi I, Yamaguchi H.
europepmc   +1 more source

MGM as a Large‐Scale Pretrained Foundation Model for Microbiome Analyses in Diverse Contexts

Advanced Science, EarlyView.
We present the Microbial General Model (MGM), a transformer‐based foundation model pretrained on over 260,000 microbiome samples. MGM learns contextualized microbial representations via self‐supervised language modeling, enabling robust transfer learning, cross‐regional generalization, keystone taxa discovery, and prompt‐guided generation of realistic,
Haohong Zhang, Yuli Zhang, Zixin Kang, Jiayun Xiong, Ronghua Yang, Kang Ning   +5 more
wiley   +1 more source

Precision targeting of rhabdomyosarcoma by combining primary CAR NK cells and radiotherapy. [PDF]

J Immunother Cancer
Reindl LM, Jalili L, Bexte T, Harenkamp S, Thul S, Hehlgans S, Wallenwein A, Rothweiler F, Cinatl J, Michaelis M, Bonig H, Gradhand E, Vogler M, Rödel F, Wels WS, Ullrich E.   +15 more
europepmc   +1 more source

Metabolic Reprogramming Driven by Trophoblasts and Decidual XCR1+PMN‐MDSC Crosstalk Controls Adverse Outcomes Associated With Advanced Maternal Age

Advanced Science, EarlyView.
The interaction between trophoblasts and decidual polymorphonuclear myeloid‐derived suppressor cells (dPMN‐MDSCs) via the XCL1–XCR1 axis is crucial for fetal development during the third trimester. Disruption of this axis impairs FOXO1 activity and causes metabolic imbalance in dPMN‐MDSCs, contributing to adverse outcomes associated with advanced ...
Meiqi Chen, Yuxiong Guo, Qing Zhao, Jingping Liu, Shuyi Kuang, Zhengcong Huang, Chenlin Lv, Shuxiu Xu, Zekai Zhuang, Anyan Yang, Jing Li, Kai Wu, Yumei He   +12 more
wiley   +1 more source

Correction: Perspective: IL-15 cytokine-armored NK cells as ready-to-use immunotherapy for diverse malignancies: therapeutic potential and toxicity risks. [PDF]

Front Immunol
Baughan SL, Folsom T, Johnson M, Kreuger J, Webber BR, Moriarity BS.   +5 more
europepmc   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source

Cytotoxic NK Cells Impede Response to Checkpoint Immunotherapy in Melanoma with an Immune-Excluded Phenotype. [PDF]

Cancer Discov
Pozniak J, Roda N, Landeloos E, Antoranz A, Van Herck Y, De Visscher A, Demaerel PG, Vanwynsberghe L, Declercq J, Gkemisis C, Bervoets G, Song NJ, Bassez A, Browaeys R, Pollaris L, Bosisio FM, Boecxstaens V, Saeys Y, Lambrechts D, Li Z, Matthys P, Bechter O, Marine JC.   +22 more
europepmc   +1 more source

ITGB1 Regulates Triple‐Negative Breast Cancer Development by Modulating the Tumor Microenvironment

Advanced Science, EarlyView.
ABSTRACT Tumorigenesis and metastasis are frequently attributed to the intricate interplay between cancer cells and the tumor microenvironment (TME). Comprehending the mechanisms and key regulators of cancer‐immune crosstalk in the TME is imperative for developing efficacious immunotherapy.
Nuozi Song, Siqi Chen, Lei Wang, Jessica Dang, Xu Cao, Stephanie Singh, Lu Yang, Jinhui Wang, Steven T. Rosen, Yingyu Wang, Chun‐Wei D. Chen, Cheng Zhang, Mingye Feng   +12 more
wiley   +1 more source

Peripheral Immune Remodeling After Spinal Cord Injury: Marked by Expansion of CD38⁺, CTLA-4⁺, and PD-1⁺ T and NK Cells. [PDF]

Neurol Neuroimmunol Neuroinflamm
Veeningen N, Añé-Kourí AL, Pues A, Rubio S, Fraussen J, Ioannou C, Martens DS, van Laake-Geelen CCM, Deckers J, Cornips EMJ, Bamps S, Gysemberg G, Van Broeckhoven J, Hellings N, Slaets H.   +14 more
europepmc   +1 more source