Results 251 to 260 of about 314,994 (315)

In Search of Adaptive-Like Features of NK Cells Co-Expressing NKG2C and NKG2A. [PDF]

Immune Netw
Alekseeva NA, Ustiuzhanina MO, Vavilova JD, Streltsova MA, Boyko AA, Sapozhnikov AM, Kovalenko EI.   +6 more
europepmc   +1 more source

A Pancreatitis‐Inspired Trypsinogen Nanoplatform Reprograms Tumor‐Associated Macrophages via NF‐κB for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
Trypsinogen‐loaded nanoparticles reprogram TAMs via NF‐κB/NLRP3, driving M2→M1 conversion and potent phagocytosis to unleash antitumor immunity. ABSTRACT Although reprogramming tumor‐associated macrophages (TAMs) represents a promising therapeutic strategy, approaches that are both precise and safe remain scarce.
Lei Cao, Yu He, Wenhao Li, Bo Gong, Han Lin, Jianlin Shi, Yuan Yong, Wencheng Wu   +7 more
wiley   +1 more source

Engineering immunity with CAR-NK cells: advancing the frontiers of cancer immunotherapy. [PDF]

Front Pharmacol
Cianga VA, Antohe I, Minciună C, Dăscălescu A.   +3 more
europepmc   +1 more source

Cerium Nanoparticle‐Mediated Inhibition of the NSUN2/m5C Axis Suppresses Synovial Aggression in Rheumatoid Arthritis

Advanced Science, EarlyView.
A novel epitranscriptomic mechanism in rheumatoid arthritis is uncovered: NSUN2 promotes disease via m5C‐dependent stabilization of ICMT mRNA, fueling the migration and invasion of pathogenic RA FLS. Targeting this axis with engineered nanoparticles (Ce/SAA NPs) effectively inhibits disease progression, presenting a precise therapeutic strategy ...
Ruiru Li, Simin Chen, Huijuan Hu, Shiyao Wu, Jingnan Wang, Kai Sun, Chenxi Peng, Suling Liu, Shuoyang Zhang, Yu Kuang, Wei Chen, Qian Qiu, Liuqin Liang, Yu Wen, Hanshi Xu, Youjun Xiao   +15 more
wiley   +1 more source

Modulating viscosity improves lentiviral transduction of NK cells: A simple solution to a persistent problem. [PDF]

Mol Ther Adv
Bjelica M, Benyoucef A, Romero H, Beland K, Gagnon E, Haddad E.   +5 more
europepmc   +1 more source

Penfluridol Triggers GSDME‐Mediated Immunogenic Pyroptosis to Potentiate Antitumor Immunotherapy

Advanced Science, EarlyView.
A high‐throughput screen of FDA‐approved antipsychotics identifies penfluridol as a potent pyroptosis inducer acting via direct TTI1 inhibition. This triggers TNFA‐NFKB signaling and caspase‐8/‐3‐dependent GSDME cleavage. The compound stimulates antitumor immunity alone and synergizes with anti‐PD‐1 therapy, while low TTI1 expression emerges as a ...
Linfeng Li, Daishi Li, Danyao Chen, Yating Dian, Lei Yao, Hui Su, Ziyu Guo, Deze Zhao, Zihua Wu, Furong Zeng, Chunfang Zhang, Guangtong Deng   +11 more
wiley   +1 more source

Exosomal SNHG26 mediates immunosuppression by impairing NK cells in tongue cancer. [PDF]

NPJ Precis Oncol
Jiang Q, Xin Y, He F, Liu C, Qiu J.
europepmc   +1 more source

Gel‐Amin for Improving Extracellular Recordings of Cardiomyocytes in a 3D Microphysiological System

Advanced Electronic Materials, EarlyView.
This work combines a conductive collagen‐based hydrogel with a laser‐cut and assembly technique to fabricate microphysiological systems that improve extracellular recordings of cardiomyocytes in 3D on microelectrode arrays. The inclusion of choline acrylate into GelMA imparts a higher electrical conductivity and improves the signal‐to‐noise ratio of on‐
Dominic Pizzarella, Katelyn Neuman, Nolan Burson, Abigail N. Koppes, Ryan A. Koppes   +4 more
wiley   +1 more source

TGF-β-driven NK Cells plasticity in hepatocellular carcinoma. [PDF]

Front Immunol
Reverberi V, Montali A, Vecchi A, Rossi M, Pelagatti A, Doselli S, Farina B, Olivani A, Economopoulos G, Dalla Valle R, Laccabue D, Ferraglia F, Penna A, Fisicaro P, Boni C, Missale G.   +15 more
europepmc   +1 more source

cGAS/STING-mediated upregulation of NKG2D ligands in LSCs contributes to enhanced sensitivity to NK cells. [PDF]

Front Oncol
Ouyang Y, Qin Y, Zhang Q, Zhu P, Zhu H.
europepmc   +1 more source