Results 271 to 280 of about 314,994 (315)
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Blood, 2010
In this issue of Blood , Baessler and colleagues find that the engagement of CD137 on mouse and human NK cells had opposite effects in that CD137 functioned as an inhibitory receptor in human NK cells and as a stimulatory receptor in mice.[1][1] As NK cells emerge as potential therapeutic ...
Jacqueline, Marvel, Thierry, Walzer
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In this issue of Blood , Baessler and colleagues find that the engagement of CD137 on mouse and human NK cells had opposite effects in that CD137 functioned as an inhibitory receptor in human NK cells and as a stimulatory receptor in mice.[1][1] As NK cells emerge as potential therapeutic ...
Jacqueline, Marvel, Thierry, Walzer
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2018
NK-cell malignancies are rare aggressive diseases associated with poor clinical outcome. There is a significant geographic variation in their incidence. At least a part of the reason for that is the fact that Epstein-Barr virus plays an important role in pathogenesis, and importantly, the plasma viral titer reflects disease burden and response to ...
Dai, Chihara, Yasuhiro, Oki
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NK-cell malignancies are rare aggressive diseases associated with poor clinical outcome. There is a significant geographic variation in their incidence. At least a part of the reason for that is the fact that Epstein-Barr virus plays an important role in pathogenesis, and importantly, the plasma viral titer reflects disease burden and response to ...
Dai, Chihara, Yasuhiro, Oki
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NK and NK/T cells in human senescence
Vaccine, 2000Natural killer (NK) cells are cytotoxic cells that play a critical role in the innate immune response against infections and tumors. Recent studies on NK cell biology have demonstrated that besides their cytotoxic function, NK cells express cytokine and chemokine receptors and also that they secrete other immunoregulatory cytokines and chemokines ...
R, Solana, E, Mariani
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Current Pharmaceutical Design, 2002
NK cells have been associated with immune surveillance of tumor cells and defense mechanisms against various pathogens. However, by their capacity for immunoregulation NK cells may also play a role in determining the response to allergens. The novel possibility that NK cell activity may in part decide development of allergic airway inflammation and ...
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NK cells have been associated with immune surveillance of tumor cells and defense mechanisms against various pathogens. However, by their capacity for immunoregulation NK cells may also play a role in determining the response to allergens. The novel possibility that NK cell activity may in part decide development of allergic airway inflammation and ...
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Annual Review of Immunology, 2005
▪ Abstract  The integrated processing of signals transduced by activating and inhibitory cell surface receptors regulates NK cell effector functions. Here, I review the structure, function, and ligand specificity of the receptors responsible for NK cell recognition.
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▪ Abstract  The integrated processing of signals transduced by activating and inhibitory cell surface receptors regulates NK cell effector functions. Here, I review the structure, function, and ligand specificity of the receptors responsible for NK cell recognition.
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International Journal of Hematology, 2002
Natural killer (NK) cells are lymphocytes with large granular lymphocyte morphology, CD3-CD56+ phenotype, non-MHC-restricted cytotoxicity, and germ-line configuration T-cell receptor genes. Two types of lymphomas originating from NK cells have been described; blastic NK-cell lymphoma, and nasal-type NK-cell lymphoma.
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Natural killer (NK) cells are lymphocytes with large granular lymphocyte morphology, CD3-CD56+ phenotype, non-MHC-restricted cytotoxicity, and germ-line configuration T-cell receptor genes. Two types of lymphomas originating from NK cells have been described; blastic NK-cell lymphoma, and nasal-type NK-cell lymphoma.
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Immunomodulation of NK Cell Activity
2019Natural killer (NK) cells can kill virus-infected cells and tumor cells without prior sensitization and secrete numerous cytokines and chemokines that modulate the activity of different cells of the immune system. The recognition of target cells is mediated by germ line-encoded receptors, and the activity of NK cells can be further regulated by soluble
Domaica, Carolina Ines +3 more
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NK Cells and Cancer Immunoediting
2015Natural killer (NK) cells are innate lymphoid cells (ILC) known for their ability to recognize and rapidly eliminate infected or transformed cells. Consequently, NK cells are fundamental for host protection against virus infections and malignancies.
Guillerey, Camille, Smyth, Mark J.
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NK Cells in the Tumor Microenvironment
2020Natural killer cells are powerful effectors of innate immunity that constitute a first line of defense against cancer. NK cells express an array of germline-encoded receptors which allow them to eliminate transformed cells and spare normal, healthy cells.
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