Results 251 to 260 of about 582,983 (289)

Loss of SOCS1 in Donor T Cells Exacerbates Intestinal GVHD by Driving a Chemokine‐Dependent Pro‐Inflammatory Immune Microenvironment

Advanced Science, EarlyView.
T cell‐specific Socs1 knockout leads to inflammatory differentiation of CD8+ T cells, prompting the STAT1/2 complex to drive the activation of Ccl5, Ccr5, and Cxcr3, and promoting the skewing of monocytes toward a pro‐inflammatory M1 macrophage lineage.
Zhigui Wu, Bixia Wang, Xinya Jiang, Fangqing Zhang, Qianqian Huang, Xinyi Wu, Shuang Fan, Qi Zhang, Jingrui Zhou, Jianing Tang, Xiao‐Dong Mo, Yu Wang, Ying‐Jun Chang, Huidong Guo, Xiao‐Jun Huang   +14 more
wiley   +1 more source

Unleashing NK cells for cancer immunotherapy in lung cancer: biologic challenges and clinical advances. [PDF]

J Exp Clin Cancer Res
McLaughlin Q, Sojka DK, Kennedy K, Piersma SJ, Sethakorn N.   +4 more
europepmc   +1 more source

Targeting CSPG4 enhances the anti-tumor activity of CAR-NK cells for glioblastoma. [PDF]

Cell Oncol (Dordr)
Xiong Q, Yin B, Jiang H, Qiu Y, Shi G, Xu J, Xu T, Deng H.   +7 more
europepmc   +1 more source

Molecular basis for selection and inhibition of HIV-1 escape virus by T cells and KIR2DL2⁺NK cells. [PDF]

Nat Commun
Chikata T, Kuroki K, Kuse N, Kliszczak AE, Paes W, Tomioka N, Parker R, Aflalo A, Akahoshi T, Zhang Y, Yamashita R, Sakata R, Kusaka H, Watanabe Y, Nicastri A, Matsubara H, Ose T, Kita S, Oka S, Gatanaga H, Lin Z, Ternette N, Borrow P, Maenaka K, Takiguchi M.   +24 more
europepmc   +1 more source

Dynamic evolution of NK cells and immune remodeling mediated by CRS + HIPEC: prognostic mechanisms and therapeutic implications for malignant peritoneal mesothelioma. [PDF]

World J Surg Oncol
Liu YT, Zhao QD, Liang XL, Ma R, Su YD, Yang R, Wei T, Wu HL, Fu YB, Cui YR, Yu Y, Li B, Li Y.   +12 more
europepmc   +1 more source

Inhibition of osteosarcoma lung metastases by β-glucan and CD40 agonist is mediated by activation of macrophages and NK cells. [PDF]

J Immunother Cancer
Shrestha P, Shrestha R, Kleinerman ES.
europepmc   +1 more source

What's in a name? Memory NK cells for cancer immunotherapy. [PDF]

J Immunother Cancer
Judge SJ, Purl MC, Murphy WJ, Canter RJ.
europepmc   +1 more source

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Human NK cells and NK receptors

Immunology Letters, 2014
In early seventies "natural killer (NK) cells", a third lymphocyte subset was discovered that revealed an unexpected ability to kill syngeneic and allogeneic tumor targets, thus emerging as the most potent non-specific cytotoxic cells in both human and mouse. Decades of research revealed the multifaceted nature of these cells. Now we know that NK cells
BELLORA, FRANCESCA, CASTRICONI, ROBERTA, DONDERO, ALESSANDRA, Carrega, Paolo, Mantovani, Alberto, Ferlazzo, Guido, MORETTA, ALESSANDRO, BOTTINO, CRISTINA   +7 more
openaire   +3 more sources

NK CELL RECEPTORS

Annual Review of Immunology, 1998
▪ Abstract  NK cells are regulated by opposing signals from receptors that activate and inhibit effector function. While positive stimulation may be initiated by an array of co-stimulatory receptors, specificity is provided by inhibitory signals transduced by receptors for MHC class I.
openaire   +2 more sources

NK CELL RECOGNITION

Annual Review of Immunology, 2005
▪ Abstract  The integrated processing of signals transduced by activating and inhibitory cell surface receptors regulates NK cell effector functions. Here, I review the structure, function, and ligand specificity of the receptors responsible for NK cell recognition.
openaire   +2 more sources