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Zoledronate activates NK cells
Blood, 2011In this issue of Blood , Nussbaumer et al demonstrate that the bisphosphonate zoledronic acid (zoledronate), a US FDA-approved drug for the prevention of osteoporosis and treatment of bone metastases in multiple myeloma and other cancers,[1][1] can enhance IFN-γ production by IL-2–primed ...
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Nonclassical NK cell education
Nature Immunology, 2012Diseased host cells are eliminated more effectively when natural killer cells grow up in the presence of classical major histocompatibility complex (MHC) class I molecules. The nonclassical MHC class I molecule H2-M3 can exert an analogous effect.
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