Results 171 to 180 of about 81,787 (272)

NLR family pyrin domain containing 12 (NLRP12; NALP12) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source

IGFBP4 is a Metric for Primary Biliary Cholangitis and Attenuates Biliary Epithelial Cell Injury

Liver International, Volume 46, Issue 3, March 2026.
ABSTRACT Background and Aims Immune‐mediated bile duct injury is the primary histological feature of autoimmune cholestatic liver diseases. Macrophages, the most abundant immune cell population in the liver, have been postulated to play a critical role in biliary repair. However, it is unclear whether activated macrophages interact with injured biliary
Xing Zhou, Shuyu Shao, Danning Yang, Ziyan Cheng, Toshihiro Tanaka, Patrick S. C. Leung, Koichi Tsuneyama, Aftab A. Ansari, William M. Ridgway, Pietro Invernizzi, Christopher L. Bowlus, M. Eric Gershwin, Weici Zhang   +12 more
wiley   +1 more source

Celastrol alleviates esophageal stricture in rats by inhibiting NLR family pyrin domain containing 3 activation. [PDF]

World J Gastroenterol
Zhang MX, Wu C, Feng XX, Tian W, Zhao NH, Lu PP, Ding Q, Liu M.   +7 more
europepmc   +1 more source

Apurinic/apyrimidinic endonuclease 1/reduction-oxidation effector factor-1 (APE1) regulates the expression of NLR family pyrin domain containing 3 (NLRP3) inflammasome through modulating transcription factor NF-κB and promoting the secretion of inflammatory mediators in macrophages. [PDF]

Ann Transl Med, 2021
Tang Z, Wang Y, Wan Y, Xie Y, Li S, Tao D, Wang C, Wu YZ, Sui JD.   +8 more
europepmc   +1 more source

Crosstalk Between Intratumoral Microbes and Tumor Immunity: Implications for Tumor Therapy

Cancer Medicine, Volume 15, Issue 2, February 2026.
ABSTRACT Background Emerging studies indicate that microbes are present in tumor cells and immune cells. Intratumoral microbiota (ITM) constitute an important component of the tumor immune microenvironment (TIME) and have an important impact on tumor progression and treatment. Objective Through the general elaboration of ITM represented by bacteria and
Fengxue Li, Lili Qiao, Xinquan Liang, Yingying Zhang, Ning Liang, Jian Xie, Guodong Deng, Yuying Hao, Pingping Hu, Xue Wu, Fangjie Ding, Can Feng, Yiming Mu, Jiandong Zhang   +13 more
wiley   +1 more source

Peroxiredoxin 1 inhibits tumorigenesis by activating the NLR family pyrin domain containing 3/gasdermin D pathway: Advanced therapies targeting heterogeneous cell death mechanisms. [PDF]

World J Gastroenterol
Smirnova A, Eygel D, Kondrasheva I, Baranovskii DS, Klabukov ID.   +4 more
europepmc   +1 more source

PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway. [PDF]

Front Aging Neurosci, 2021
Samidurai M, Palanisamy BN, Bargues-Carot A, Hepker M, Kondru N, Manne S, Zenitsky G, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A.   +10 more
europepmc   +1 more source

The ZNF148‐ZEB1‐AS1‐IGF2BP2‐NOD2 Axis Drives Microglial Antipneumococcal Immunity in Bacterial Meningitis

Glia, Volume 74, Issue 2, February 2026.
ZNF148 upregulates ZEB1‐AS1, which scaffolds IGF2BP2 to stabilize NOD2 mRNA, enhancing microglial anti‐pneumococcal immunity via cytokine production and bacterial clearance in bacterial meningitis. ABSTRACT Streptococcus pneumoniae (Spn) meningitis remains a lethal central nervous system (CNS) infection with limited therapies. This study identifies the
Xiufu Hu, Fang Jiang, Xinjie Liu, Ling Li, Ruimei Hu, Meng Dong, Aihua Cao   +6 more
wiley   +1 more source

Small family, big impact: RNL helper NLRs and their importance in plant innate immunity

PLOS Pathogens, 2023
Svenja C. Saile, Farid El Kasmi
openaire   +4 more sources

Hippo Signaling Controls NLR Family Pyrin Domain Containing 3 Activation and Governs Immunoregulation of Mesenchymal Stem Cells in Mouse Liver Injury

, 2019
Changyong Li, Yuting Jin, Song Wei, Yishuang Sun, Longfeng Jiang, Qiang Zhu, Douglas G. Farmer, Ronald W. Busuttil, Jerzy W. Kupiec‐Weglinski, Bibo Ke   +9 more
openalex   +2 more sources