Results 191 to 200 of about 87,795 (274)

NLR family gene methylation correlates with survival in breast cancer.

We studied mechanisms that specifically and significantly influence survival in human cancer by comparing DNA methylation globally in patient tumors based on total number of days (overall survival). We identified numerous instances of differential methylation of NLR family genes which was quantitatively significant indicating a family-specific property
openaire   +2 more sources

Zebrafish as an Anti‐Isogenic Vertebrate Model and What It Reveals About Genetic Background and Reproducibility

BioEssays, Volume 48, Issue 6, June 2026.
Zebrafish illustrates how polygenic sex determination, maternal germline bottlenecks, and a structurally restless genome jointly destabilize deep homozygosity. These interlocking constraints make fully isogenic zebrafish lines effectively unattainable, turning this model into a natural “stress test” for assumptions about genetic background and ...
Álvaro J. Arana, Laura Sánchez
wiley   +1 more source

Inter-relationships of galectin-3 and NLR family pyrin domain containing 3 inflammasomes with oral lichen planus: a preliminary cross-sectional in vitro study. [PDF]

BMC Oral Health
Chen S, Xu X, Liu Y, Yao Y, Yang Y, Meng W.   +5 more
europepmc   +1 more source

Integrated Blood Inflammatory Ratios and Cerebrospinal Fluid Blood‒Brain Barrier Dysfunction Predict Relapse Risk in Neuromyelitis Optica Spectrum Disorder

Brain and Behavior, Volume 16, Issue 6, June 2026.
ABSTRACT Background Relapse is the primary driver of irreversible disability accumulation in neuromyelitis optica spectrum disorder (NMOSD). Although aquaporin‐4 immunoglobulin G (AQP4‐IgG) is central to disease diagnosis and pathogenesis, reliable tools for individualized relapse risk stratification remain limited.
Xingyue Zheng, Jing Shi, Hao Yin, Huiqun Song, Quanhua Zhai, Cuiping Si, Jianwen Chen, Peixue Li, Lei Zhang, Yuzhi Li, Chunbo Dong, Huakun Liu   +11 more
wiley   +1 more source

NLR family CARD domain containing 5 promotes hypoxia-induced cancer progress and carboplatin resistance by activating PI3K/AKT via carcinoembryonic antigen related cell adhesion molecule 1 in non-small cell lung cancer.

Bioengineered, 2022
Dong Y, Xu T, Li D, Guo H, Du X, Li G, Chen J, Wang B, Wang P, Yu G, Zhao X, Xue R.   +11 more
europepmc   +1 more source

Immunogenic Cell Death: Unlocking New Frontiers in Cancer Immunotherapy

Cancer Innovation, Volume 5, Issue 3, June 2026.
Immunogenic cell death ICD is a specific type of stress‐induced cell death that results in adaptive immune response and generating an immunological memory. The development of strategies that induce ICD are considered highly effective in the treatment of cancer within the bounds of immunotherapy.
Katherine Yaacoub
wiley   +1 more source

Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes. [PDF]

Eur J Med Res
Chen F, Xing Y, Chen Z, Chen X, Li J, Gong S, Luo F, Cai Q.   +7 more
europepmc   +1 more source

The Prognostic Value of Serum Inflammatory Markers in Nasopharyngeal Carcinoma Patients Treated With Immune Checkpoint Inhibitors: A Multicenter Study

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Background Although immune checkpoint inhibitors (ICIs) have revolutionized the treatment of nasopharyngeal carcinoma (NPC), reliable predictive biomarkers need to be further explored. This study aimed to investigate the predictive ability of inflammatory markers for poor prognosis in NPC patients treated with ICIs. Methods In this multicenter
Yang Xu, Jingyi Xie, Danmeng Zhang, Liru Zhu, Xiaojun Chen, Qingqing Zhang, Haoyu Lv, Kaihua Chen, Ling Li, Song Qu, Xishan Chen, Wenqi Liu, Xiaodong Zhu   +12 more
wiley   +1 more source

The Protein Kinase R Inhibitor C16 Alleviates Sepsis-Induced Acute Kidney Injury Through Modulation of the NF-κB and NLR Family Pyrin Domain-Containing 3 (NLPR3) Pyroptosis Signal Pathways. [PDF]

Med Sci Monit, 2020
Zhou J, Zhang F, Lin H, Quan M, Yang Y, Lv Y, He Z, Qian Y.   +7 more
europepmc   +1 more source

MRI‐Based DeltaHabitat Radiomic Model Predicts Pathological Complete Response in Oral Cavity Cancer Treated With Neoadjuvant Chemoimmunotherapy

Cancer Medicine, Volume 15, Issue 6, June 2026.
ABSTRACT Objective This study aimed to develop and validate an MRI‐based DeltaHabitat radiomics model to predict pathological complete response (pCR) in oral cavity squamous cell carcinoma (OCSCC) patients treated with neoadjuvant chemoimmunotherapy. Methods Patients treated with neoadjuvant chemoimmunotherapy and surgery were retrospectively included ...
Lin Ding, Jialing Wu, Yangxin Liang, Jiaxuan Ding, Shu Zhou, Liting Li, Lehang Lin, Jiale Zeng, Changlong Chen   +8 more
wiley   +1 more source