Results 201 to 210 of about 4,243,571 (286)

NLR family pyrin domain containing 3 (NLRP3; NALP3) [PDF]

Science-Business eXchange, 2011
openaire   +1 more source

Mitochondrial DNA: A Key Alarmin Igniting the Inflammasome Fire in Health and Disease

Immunology, Volume 178, Issue 2, Page 218-230, June 2026.
This review illustrates how mitochondrial DNA, released under cellular stress, acts as a key alarmin that ignites innate immune sensors, particularly inflammasomes and the cGAS‐STING pathway. This paper details how this sustained “inflammasome fire” fuels the progression of diverse inflammatory diseases, including neurodegeneration and metabolic ...
Woo Hyun Park
wiley   +1 more source

Celastrol alleviates esophageal stricture in rats by inhibiting NLR family pyrin domain containing 3 activation. [PDF]

World J Gastroenterol
Zhang MX, Wu C, Feng XX, Tian W, Zhao NH, Lu PP, Ding Q, Liu M.   +7 more
europepmc   +1 more source

Apurinic/apyrimidinic endonuclease 1/reduction-oxidation effector factor-1 (APE1) regulates the expression of NLR family pyrin domain containing 3 (NLRP3) inflammasome through modulating transcription factor NF-κB and promoting the secretion of inflammatory mediators in macrophages. [PDF]

Ann Transl Med, 2021
Tang Z, Wang Y, Wan Y, Xie Y, Li S, Tao D, Wang C, Wu YZ, Sui JD.   +8 more
europepmc   +1 more source

Structure and sequence evolution in the pennycress (Thlaspi arvense) pangenome

New Phytologist, Volume 250, Issue 5, Page 2723-2741, June 2026.
Summary Eukaryotic genomes harbor many forms of variation, including nucleotide diversity and structural polymorphisms, which experience natural selection and contribute to genome evolution and biodiversity. Harnessing this variation for agriculture hinges on our ability to detect, quantify, catalog, and deploy genetic diversity. Here, we explore seven
Kevin A. Bird, Joanna L. Rifkin, Chloee M. McLaughlin, Avril M. Harder, Pawan Basnet, Ella Katz, Tomáš Brůna, Kerrie Barry, LoriBeth Boston, Christopher Daum, Jie Guo, Anna Lipzen, Christopher Plott, Jerry W. Jenkins, Rachel Walstead, Shanmugam Rajasekar, Jayson Talag, Katherine Frels, Kathleen Greenham, Shelby Ellison, Jane Grimwood, Jeremy Schmutz, Patrick P. Edger, J. Chris Pires, John T. Lovell, Daniel J. Kliebenstein   +25 more
wiley   +1 more source

Peroxiredoxin 1 inhibits tumorigenesis by activating the NLR family pyrin domain containing 3/gasdermin D pathway: Advanced therapies targeting heterogeneous cell death mechanisms. [PDF]

World J Gastroenterol
Smirnova A, Eygel D, Kondrasheva I, Baranovskii DS, Klabukov ID.   +4 more
europepmc   +1 more source

PKC Delta Activation Promotes Endoplasmic Reticulum Stress (ERS) and NLR Family Pyrin Domain-Containing 3 (NLRP3) Inflammasome Activation Subsequent to Asynuclein-Induced Microglial Activation: Involvement of Thioredoxin-Interacting Protein (TXNIP)/Thioredoxin (Trx) Redoxisome Pathway. [PDF]

Front Aging Neurosci, 2021
Samidurai M, Palanisamy BN, Bargues-Carot A, Hepker M, Kondru N, Manne S, Zenitsky G, Jin H, Anantharam V, Kanthasamy AG, Kanthasamy A.   +10 more
europepmc   +1 more source

Small family, big impact: RNL helper NLRs and their importance in plant innate immunity

PLOS Pathogens, 2023
Svenja C. Saile, Farid El Kasmi
openaire   +4 more sources

Conserved effector families of Phytophthora species drive NLR-mediated nonhost resistance in plants

Abstract Nucleotide-binding leucine-rich repeat (NLR) receptor is suggested as a component of nonhost resistance (NHR). However, the evolutionary process of how plants develop receptors for recognizing wide range of non-adapted pathogens is still elusive.
Doil Choi, Soohyun Oh, Myung-Shin Kim, Hui Jeong Kang, Taewon Kim, Junhyeong Kong   +5 more
openaire   +1 more source

Constitutive and inducible oleoresin defenses share genetic architectures and mechanisms in Pinus taeda

New Phytologist, Volume 250, Issue 5, Page 2966-2987, June 2026.
Summary The oleoresin defense system of loblolly pine (Pinus taeda) protects trees from insects and pathogens and is an important source of renewable biofuels and chemicals, but the genetic basis of oleoresin production is poorly understood. We characterized the genetic architecture of oleoresin flow, resin canal number, stem wood terpene content, and ...
Mallory M. Morgan, Jared Westbrook, Christopher Dervinis, Tania Quesada, Salvador Gezan, Robert Sykes, Timothy S. Johnson, Gabriela Madrid, Matthew Lane, Alice Townsend, Thomas A. Colquhoun, John M. Davis, Daniel Jacobson, Gary F. Peter   +13 more
wiley   +1 more source