Results 211 to 220 of about 4,243,571 (286)

NLR family pyrin domain containing 3 (NLRP3; NALP3) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

An antiviral jacalin‐like lectin gene contributes to nonhost resistance and host determination of potexviruses among Brassicaceae

New Phytologist, Volume 250, Issue 5, Page 3283-3298, June 2026.
Summary Plant resistance influences the host range of pathogens; however, the mechanism driving this influence remains poorly understood. Brassicaceae species are not natural hosts of potexviruses, for reasons that have not yet been determined. This study investigated the molecular basis of nonhost resistance (NHR) to potexviruses in the Brassicaceae ...
Takumi Suzuki, Kazuya Ishikawa, Akira Yusa, Nozomu Iwabuchi, Kan Kimura, Tetsuya Yoshida, Mari Ota, Masato Suzuki, Masanobu Nishikawa, Kensaku Maejima, Shigetou Namba, Yasuyuki Yamaji   +11 more
wiley   +1 more source

Immune Checkpoint Inhibitors and Immunomodulators for Cancer Immunotherapy: Insights Into Resistance and Therapeutic Strategies

Advanced Science, Volume 13, Issue 25, 4 May 2026.
The schematic diagram illustrates the roles of novel immune checkpoints, immunomodulatory factors, cell death and multimodal technologies in cancer immunotherapy. Abstract Cancer immunotherapy has redefined cancer treatment. However, the molecular and cellular basis of immune evasion and therapeutic resistance remains incompletely understood.
Fangquan Chen, Yang Yu, Xiutao Cai, Junhao Lin, Ruirui Liang, Rui Kang, Daolin Tang, Jiao Liu   +7 more
wiley   +1 more source

Insights into the structure of NLR family member X1: Paving the way for innovative drug discovery. [PDF]

Comput Struct Biotechnol J
Jewell S, Nguyen TB, Ascher DB, Robertson AAB.   +3 more
europepmc   +1 more source

Molecular Stratification of Antiphospholipid Syndrome Through Integrative Analysis of the Whole‐Blood RNA Transcriptome

Arthritis &Rheumatology, Volume 78, Issue 5, Page 1124-1133, May 2026.
Objective Antiphospholipid syndrome (APS) is a thromboinflammatory disorder characterized by clinical and mechanistic heterogeneity that complicates early diagnosis and hinders targeted treatment. We aimed to identify distinct molecular endotypes among antiphospholipid antibody (aPL)–positive patients using whole‐blood transcriptomics.
Amala Ambati, Feiyang Ma, Katarina Kmetova, Sherwin Navaz, Claire K. Hoy, Cyrus Sarosh, Ajay Tambralli, Erika Navarro‐Mendoza, Johann E. Gudjonsson, J. Michelle Kahlenberg, Jacqueline A. Madison, Alí Duarte‐García, Jason S. Knight, Yu Zuo   +13 more
wiley   +1 more source

An NLR family member X1 mutation (p.Arg707Cys) suppresses hepatitis B virus infection in hepatocytes and favors the interaction of retinoic acid-inducible gene 1 with mitochondrial antiviral signaling protein. [PDF]

Arch Virol
Jiao Q, Zhu S, Liao B, Liu H, Guo X, Wu L, Chen C, Peng L, Xie C.   +8 more
europepmc   +1 more source

Association and Comparative Analysis of Four Inflammatory Indices With 90‐Day Outcomes in Acute Ischemic Stroke Patients Treated With Intravenous Thrombolysis

Brain and Behavior, Volume 16, Issue 5, May 2026.
ABSTRACT Objective To investigate and compare the associations of the systemic immune‐inflammation index (SII), the systemic inflammation response index (SIRI), the platelet‐to‐lymphocyte ratio (PLR), and the neutrophil‐to‐lymphocyte ratio (NLR) with 90‐day functional outcomes in AIS patients treated with IV rt‐PA., with particular attention to their ...
Xinping Bai, Xiangyu Wu, Zhuo Cai, Hao Cheng, Juluo Chen   +4 more
wiley   +1 more source

Inter-relationships of galectin-3 and NLR family pyrin domain containing 3 inflammasomes with oral lichen planus: a preliminary cross-sectional in vitro study. [PDF]

BMC Oral Health
Chen S, Xu X, Liu Y, Yao Y, Yang Y, Meng W.   +5 more
europepmc   +1 more source

A Novel Nomogram Incorporating the Aggregate Index of Systemic Inflammation, Clinicopathological Parameters and Molecular Classification to Predict Recurrence of Endometrial Cancer: A Multi‐Center Retrospective Study

Cancer Medicine, Volume 15, Issue 5, May 2026.
ABSTRACT This study evaluated the aggregate index of systemic inflammation (AISI) for predicting postoperative recurrence in endometrial cancer (EC). A total of 1557 patients were enrolled and divided into training (n = 1030) and validation (n = 527) cohorts. The optimal AISI cutoff was determined by ROC curve analysis.
Chenfan Tian, Na Zeng, Yuan Tu, Chunxia Gong, Jiaxin Yu, Kunying Rao, Peng Jiang   +6 more
wiley   +1 more source

SYK Signalling in NLRP3 Inflammasome‐Mediated Response of Murine Microglia Activated by Immune Complexes Formed of Viral Proteins and Specific IgG

European Journal of Immunology, Volume 56, Issue 5, May 2026.
IC‐mediated inflammatory response—the NLRP3 inflammasome activation, cytokine secretion, and antigen presentation depend on SYK signalling pathways in primary murine microglia. ABSTRACT Viral infections might trigger systemic inflammatory responses characterised by inflammasome activation and cytokine release, driven by immune complex (IC) formation ...
Kristina Mašalaitė, Milda Norkienė, Aurelija Žvirblienė, Asta Lučiūnaitė   +3 more
wiley   +1 more source