Results 231 to 240 of about 4,243,571 (286)
High‐Throughput Screening Reveals That CeeNU Acts as a New NLRP3 Inflammasome Inhibitor
MedComm, Volume 7, Issue 5, May 2026.We conducted a high‐throughput screen of 2747 FDA‐approved drugs to identify inhibitors of pyroptosis. We found that CeeNU significantly repressed NLRP3‐dependent IL‐1β release and GSDMD pore‐forming complex. We identified that the arginine 335 amino acid of the NACHT domain of NLRP3 is the critical point for human NLRP3 and CeeNU interaction and ...
Sen‐Lin Ji +11 more
wiley +1 more source
Chronic Pain: Epidemiology, Pathophysiology, and Clinical Management
MedComm, Volume 7, Issue 5, May 2026.The multidimensional nature of chronic pain is illustrated through four interconnected domains. (Left) Epidemiology and Global Burden: Chronic pain affects approximately one in five individuals globally, contributing to a rising trend in disability‐adjusted life years (YLDs) and a significant socioeconomic impact.
Zhihao Shang +12 more
wiley +1 more source
NLR family pyrin domain containing 3 (NLRP3; NALP3); caspase-1 (CASP1) [PDF]
Science-Business eXchange, 2013 openaire +1 more source
Molecular Nutrition &Food Research, Volume 70, Issue 9, 13 May 2026.ABSTRACT Gallic acid (GA), a plant‐derived phenolic compound, is evolving from a general antioxidant into a specific molecular modulator and a functional building block for advanced biomedical materials. This review synthesizes recent insights underpinned by GA's “redox duality”—its capacity to act as either a radical scavenger or a pro‐oxidant.
Woo Hyun Park
wiley +1 more source
Overexpressed CD39 mitigates sepsis‑induced kidney epithelial cell injury via suppressing the activation of NLR family pyrin domain containing 3. [PDF]
Int J Mol Med, 2019 Yang M, Lu L, Kang Z, Ma T, Wang Y.
europepmc +1 more source
NLR family pyrin domain containing 3 (NLRP3; NALP3; CIAS1); IL-1β [PDF]
Science-Business eXchange, 2009 openaire +1 more source
British Journal of Pharmacology, Volume 183, Issue 10, Page 2177-2196, May 2026.Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi +10 more
wiley +1 more source
Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 3883-3894, May 2026.Abstract Aims Obesity, systemic inflammation, and hyperinsulinemia are all features of metabolic syndrome and frequently occur together. We aimed to evaluate the association of body mass index (BMI) with incident non‐communicable chronic disease (NCD) or all‐cause mortality, independent of C‐reactive protein (CRP) and fasting insulin.
Natasha Wiebe +5 more
wiley +1 more source
Immunology, Volume 178, Issue 1, Page 109-117, May 2026.This study shows that 8 weeks of high‐intensity interval training (HIIT) modulate inflammasome‐related gene expression in individuals with obesity. HIIT increased AIM2, MEFV, CARD16 and CARD18 expression, with CARD16 upregulation supporting reduced inflammation through inhibition of caspase‐1 activation and lower IL‐1β levels.
Ana Luíza Pereira Assunção Silveira +8 more
wiley +1 more source
Research Topics and Trends in MIMIC‐IV: A Large ICU Database Relevant for Critical Care Nursing
Nursing in Critical Care, Volume 31, Issue 3, May 2026.ABSTRACT Background The Medical Information Mart for Intensive Care‐IV (MIMIC‐IV) clinical database has become a central resource for data‐driven critical care research, enabling advances in clinical informatics, machine learning and nursing science.
Yuh‐Shan Ho +5 more
wiley +1 more source