Results 221 to 230 of about 90,508 (248)

NLR family genes influence homeobox transcription factor expression.

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Pan-NLRome Analysis of Cultivated Tomato and Wild Solanum Relatives Reveals an Open Immune Repertoire Dominated by Spatially Dispersed Homologs. [PDF]

Genes (Basel)
Meng S, Zhu J, Hu E, Liu J, Cheng Y, Ruan M, Liu C, Ye Q, Wang R, Yao Z, Li Z, Zhou G, Wan H, Chen Y.   +13 more
europepmc   +1 more source

Alpha synuclein expression is regulated by the NLR family gene NLRP7.

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Comparative genomics across <i>Linum</i> illuminates the evolutionary basis of flax domestication, genome diversification, and seed oil biosynthesis. [PDF]

Front Genet
Yi L, Sa R, Mu Y, Zhang J, He R, Song Y, Zhou Y, Chen Y.   +7 more
europepmc   +1 more source

Expression of the NLRP12/NF-κB/iNOS axis in lung tissues across stages of non-small cell lung cancer and its mechanism in mediating immune cell regulation. [PDF]

Transl Cancer Res
Xue M, Shi M, Chen J, Wu X.
europepmc   +1 more source

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The NLR gene family: from discovery to present day

Nature Reviews Immunology, 2023
The mammalian NLR gene family was first reported over 20 years ago, although several genes that were later grouped into the family were already known at that time. Although it is widely known that NLRs include inflammasome receptors and/or sensors that promote the maturation of caspase 1, IL-1β, IL-18 and gasdermin D to drive inflammation and cell ...
Jenny Ting, Sushmita Jha, Wei-Chun Chou   +2 more
exaly   +3 more sources

Evolutionary history of the NLR gene families across lophotrochozoans

Gene, 2022
NOD-like receptor (NLR) genes are critical innate immune receptors in animals and plants. Lophotrochozoans represent one of the most species-rich superphyla that includes molluscs, segmented worms, flatworms, bryozoans, and other invertebrates, which is crucial to our understanding of immune system evolution in bilaterians.
Xiaofei Zhu, Kang Mu, Yi Wan, Linlin Zhang   +3 more
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Inflammasome-Independent Roles of NLR and ALR Family Members

2023
Pattern recognition receptors, including members of the NLR and ALR families, are essential for recognition of both pathogen- and host-derived danger signals. Several members of these families, including NLRP1, NLRP3, NLRC4, and AIM2, are capable of forming multiprotein complexes, called inflammasomes, that result in the activation of pro-inflammatory ...
Suman, Gupta, Suzanne L, Cassel, Fayyaz S, Sutterwala   +2 more
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Progresses on three pattern recognition receptor families (TLRs, RLRs and NLRs) in teleost

Developmental & Comparative Immunology, 2021
Pattern recognition receptors (PRRs) are a class of immune sensors that play crucial roles in detecting and responding to the conserved patterns of microorganisms. To date, many PRRs, such as TLRs, RLRs and NLRs, as well as their downstream molecules have been identified and characterized in teleost, while their ligands and immunoregulatory mechanisms ...
Zhiwei Liao, Jianguo Su
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ARABIDOPSIS HELPER NLRS SIGNAL BOTH DOWNSTREAM OF SENSOR NLRS AND EXHIBIT INTER HELPER FAMILY INTERACTIONS

2021
Plants constantly face pathogen threat. To defend themselves, plants evolved an immune system comprised of extracellular pattern recognition receptors (PRRs) and intracellular nucleotide-binding leucine-rich repeat (NLR) proteins. NLRs, which sense pathogen effector proteins, can be further categorized as sensor NLRs (sNLRs) or helper NLRs (hNLRs ...
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