Results 31 to 40 of about 81,787 (272)
The NLR family of innate immune and cell death sensors. [PDF]
ImmunityNucleotide-binding oligomerization domain (NOD)-like receptors, also known as nucleotide-binding leucine-rich repeat receptors (NLRs), are a family of cytosolic pattern recognition receptors that detect a wide variety of pathogenic and sterile triggers. Activation of specific NLRs initiates pro- or anti-inflammatory signaling cascades and the formation
Sundaram B +3 more
europepmc +3 more sources
Pro-Inflammatory of PRDM1/SIRT2/NLRP3 Axis in Monosodium Urate-Induced Acute Gouty Arthritis
Journal of Innate Immunity, 2023 PR domain-containing 1 with zinc finger domain (PRDM1) has been reported as a promoter of inflammation, which is a critical process involved in the pathogenesis of acute gouty arthritis.
Qingsong Zhao +6 more
doaj +1 more source
Insights into the structure of NLR family member X1: Paving the way for innovative drug discovery. [PDF]
Comput Struct Biotechnol JJewell S +3 more
europepmc +2 more sources
The NLR Gene Family: A Standard Nomenclature [PDF]
Immunity, 2008 Iimmune regulatory proteins such as CIITA, NAIP, IPAF, NOD1, NOD2, NALP1, cryopyrin/NALP3 are members of a family characterized by the presence of a nucleotide-binding domain (NBD) and leucine-rich repeats (LRR). Members of this gene family encode a protein structure similar to the NB-LRR subgroup of disease-resistance genes in plants and are involved ...
Ting, Jenny P.-Y. +23 more
openaire +4 more sources
BMC Plant Biology, 2023 Resistance genes (R genes) are a class of genes that are immune to a wide range of diseases and pests. In planta, NLR genes are essential components of the innate immune system.
Haixiang Yu +8 more
doaj +1 more source
Predictive Value of Neutrophil Lymphocyte Ratio and Platelet Lymphocyte Ratio in Immediate Outcomes of ST-elevation Myocardial Infarction: A Cross-sectional Study [PDF]
Journal of Clinical and Diagnostic Research, 2021 Introduction: There have been various inflammatory markers implicated in the pathogenesis of Acute Coronary Syndromes (ACS). However, the role of the Neutrophil Lymphocyte Ratio (NLR) and Platelet Lymphocyte Ratio (PLR) as prognostic markers in ST ...
Sneha Barkur sadashiva, KS Chenthil
doaj +1 more source
Comparative-genomic analysis reveals dynamic NLR gene loss and gain across Apiaceae species
Frontiers in Genetics, 2023 Introduction: Nucleotide-binding leucine-rich repeat (NLR) genes play a crucial role in green plants’ responding to various pathogens. Genome-scale evolutionary studies of NLR genes are important for discovering and applying functional NLR genes. However,
Xiaohui Liang, Junming Dong
doaj +1 more source
Regulation of intestinal microbiota by the NLR protein family [PDF]
International Immunology, 2013 Abstract The human intestine harbors a diverse microbial community consisting of a large number of bacteria and other micro-organisms that have co-evolved with the host intestinal immune system. During this process, microbiota and the host immune system shape one another by various mechanisms to achieve a successful symbiotic ...
Amlan, Biswas, Koichi S, Kobayashi
openaire +2 more sources
Agronomy, 2023 Carica papaya maintains an abnormally small but complete NLR family while showing weak disease resistance. To better understand their origin, evolution, and biological function, we identified 59 NLR genes via a customized RGAugury and investigated their ...
Qian Jiang +8 more
doaj +1 more source
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source