Results 11 to 20 of about 82,639 (162)
The Nod-like receptor (NLR) family: a tale of similarities and differences. [PDF]
PLoS ONE, 2008 Innate immunity represents an important system with a variety of vital processes at the core of many diseases. In recent years, the central role of the Nod-like receptor (NLR) protein family became increasingly appreciated in innate immune responses ...
Martina Proell +4 more
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NLR receptor networks in plants
Essays in Biochemistry, 2022 Abstract To fight off diverse pathogens and pests, the plant immune system must recognize these invaders; however, as plant immune receptors evolve to recognize a pathogen, the pathogen often evolves to escape this recognition. Plant–pathogen co-evolution has led to the vast expansion of a family of intracellular immune receptors ...
Adachi, Hiroaki, Kamoun, Sophien
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Pattern-recognition receptors are required for NLR-mediated plant immunity [PDF]
Nature, 2021 The plant immune system is fundamental for plant survival in natural ecosystems and for productivity in crop fields. Substantial evidence supports the prevailing notion that plants possess a two-tiered innate immune system, called pattern-triggered immunity (PTI) and effector-triggered immunity (ETI).
Minhang Yuan +9 more
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Activation and Regulation of NLR Immune Receptor Networks
Plant and Cell Physiology, 2022 AbstractPlants have many types of immune receptors that recognize diverse pathogen molecules and activate the innate immune system. The intracellular immune receptor family of nucleotide-binding domain leucine-rich repeat-containing proteins (NLRs) perceives translocated pathogen effector proteins and executes a robust immune response, including ...
Jiorgos Kourelis, Hiroaki Adachi
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Diverse
New Phytologist, 2019 Summary Most land plant genomes carry genes that encode RPW8‐NLR Resistance (R) proteins. Angiosperms carry two RPW8‐NLR subclasses: ADR1 and NRG1. ADR1s act as ‘helper’ NLRs for multiple TIR‐ and CC‐NLR R proteins in Arabidopsis. In angiosperm families, NRG1 co‐occurs with TIR‐NLR Resistance (R) genes.
Castel, Baptiste +7 more
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Pathways to engineering plant intracellular NLR immune receptors
Current Opinion in Plant Biology, 2023 Factors including climate change and increased global exchange are set to escalate the prevalence of plant diseases, posing an unprecedented threat to global food security and making it more challenging to meet the demands of an ever-growing population.
Rafał Zdrzałek +4 more
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Matching NLR Immune Receptors to Autoimmunity in camta3 Mutants Using Antimorphic NLR Alleles [PDF]
Cell Host & Microbe, 2017 To establish infection, pathogens deploy effectors to modify or remove host proteins. Plant immune receptors with nucleotide-binding, leucine-rich repeat domains (NLRs) detect these modifications and trigger immunity. Plant NLRs thus guard host "guardees." A corollary is that autoimmunity may result from inappropriate NLR activation because mutations ...
Lolle, Signe +9 more
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Plant TRAF Proteins Regulate NLR Immune Receptor Turnover [PDF]
Cell Host & Microbe, 2016 In animals, Tumor necrosis factor receptor-associated factor (TRAF) proteins are molecular adaptors that regulate innate and adaptive immunity, development, and abiotic stress responses. Although gene families encoding TRAF domain-containing proteins exhibit enriched diversity in higher plants, their biological roles are poorly defined. Here, we report
Huang, Shuai +6 more
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Structural insights into plant NLR immune receptor function [PDF]
Proceedings of the National Academy of Sciences, 2016 Plants and animals use intracellular innate immune receptors known as nucleotide-binding oligomerization domain-like receptors (NLRs) to detect the presence of pathogens and activate defense. Although genetic studies have defined an increasing number of receptors and the pathogen triggers that activate them, the structural and mechanistic underpinnings
Farid El Kasmi, Marc T. Nishimura
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NOD‐like receptor (NLR) signaling beyond the inflammasome [PDF]
European Journal of Immunology, 2010 AbstractRecent years have witnessed a marked progress in our knowledge of NOD‐like receptors (NLR), intracellular sensors with central roles in innate and adaptive immunity. A majority of the research has focused on caspase‐1 inflammasomes. However, several members of the mammalian NLR family exert important roles in immunity beyond inflammasome ...
Patrick J, Shaw +2 more
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