Results 11 to 20 of about 98,851 (337)
The Nod-like receptor (NLR) family: a tale of similarities and differences. [PDF]
PLoS ONE, 2008 Innate immunity represents an important system with a variety of vital processes at the core of many diseases. In recent years, the central role of the Nod-like receptor (NLR) protein family became increasingly appreciated in innate immune responses ...
Martina Proell +4 more
doaj +5 more sources
NLR immune receptor-nanobody fusions confer plant disease resistance [PDF]
, 2021 ABSTRACTPlant pathogens cause recurrent epidemics that threaten crop yield and global food security. Efforts to retool the plant immune system have been limited to modifying natural components and can be nullified by the emergence of new pathogen races. Therefore, there is a need to develop made-to-order synthetic plant immune receptors with resistance
Jiorgos Kourelis +2 more
+4 more sources
Interplay between cell‐surface receptor and intracellular NLR‐mediated immune responses [PDF]
New Phytologist, 2023 SummaryThe functional link between cell‐surface receptors and intracellular NLR immune receptors is a critical aspect of plant immunity. To establish disease, successful pathogens have evolved mechanisms to suppress cell‐surface immune signalling. In response, plants have adapted by evolving NLRs that recognize pathogen effectors involved in this ...
Jiorgos Kourelis
openalex +6 more sources
NLR immune receptor–nanobody fusions confer plant disease resistance
Science, 2023 Plant pathogens cause recurrent epidemics, threatening crop yield and global food security. Efforts to retool the plant immune system have been limited to modifying natural components and can be nullified by the emergence of new pathogen strains. Made-to-order synthetic plant immune receptors provide an opportunity to tailor resistance to pathogen ...
Jiorgos Kourelis +4 more
openalex +5 more sources
NOD-like receptors (NLRs): bona fide intracellular microbial sensors [PDF]
Current Opinion in Immunology, 2008 The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) (nucleotide-binding domain leucine-rich repeat containing) family of proteins has been demonstrated to function as regulators of innate immune response against microbial pathogens.
Michael H Shaw +3 more
openalex +4 more sources
NLR receptor networks in plants
Essays in Biochemistry, 2022 Abstract To fight off diverse pathogens and pests, the plant immune system must recognize these invaders; however, as plant immune receptors evolve to recognize a pathogen, the pathogen often evolves to escape this recognition. Plant–pathogen co-evolution has led to the vast expansion of a family of intracellular immune receptors ...
Adachi, Hiroaki, Kamoun, Sophien
openaire +4 more sources
Conifers Concentrate Large Numbers of NLR Immune Receptor Genes on One Chromosome [PDF]
Genome Biology and Evolution, 2023 AbstractNucleotide-binding domain and Leucine-rich Repeat (NLR) immune receptor genes form a major line of defence in plants, acting in both pathogen recognition and resistance machinery activation. NLRs are reported to form large gene clusters in limber pine (Pinus flexilis) but it is unknown how widespread this genomic architecture may be among the ...
Yannick Woudstra +13 more
+7 more sources
An atypical NLR protein modulates the NRC immune receptor network [PDF]
, 2021 ABSTRACTThe NRC immune receptor network has evolved in asterid plants from a pair of linked genes into a genetically dispersed and phylogenetically structured network of sensor and helper NLR (nucleotide-binding domain and leucine-rich repeat-containing) proteins.
Hiroaki Adachi +6 more
openalex +2 more sources
Activation and Regulation of NLR Immune Receptor Networks
Plant and Cell Physiology, 2022 AbstractPlants have many types of immune receptors that recognize diverse pathogen molecules and activate the innate immune system. The intracellular immune receptor family of nucleotide-binding domain leucine-rich repeat-containing proteins (NLRs) perceives translocated pathogen effector proteins and executes a robust immune response, including ...
Jiorgos Kourelis, Hiroaki Adachi
openaire +5 more sources
The new era of bioengineered plant NLR receptors. [PDF]
Plant CommunCao P +5 more
europepmc +2 more sources