Results 51 to 60 of about 82,639 (162)
Kaohsiung Journal of Medical Sciences, 2023 The neutrophil‐to‐lymphocyte ratio (NLR) has been extensively studied in patients with gastric cancer (GC) treated with immune checkpoint inhibitors (ICIs), although the results are controversial.
Li‐Li Li, Li‐Sha Pan
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NOD1 cooperates with TLR2 to enhance T cell receptor-mediated activation in CD8 T cells. [PDF]
PLoS ONE, 2012 Pattern recognition receptors (PRR), like Toll-like receptors (TLR) and NOD-like receptors (NLR), are involved in the detection of microbial infections and tissue damage by cells of the innate immune system. Recently, we and others have demonstrated that
Blandine C Mercier +6 more
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Genome-Wide Analysis of NLR Disease Resistance Genes in an Updated Reference Genome of Barley
Frontiers in Genetics, 2021 Barley is one of the top 10 crop plants in the world. During its whole lifespan, barley is frequently infected by various pathogens. In this study, we performed genome-wide analysis of the largest group of plant disease resistance (R) genes, the ...
Qian Li, Xing-Mei Jiang, Zhu-Qing Shao
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An atypical NLR protein modulates the NRC immune receptor network [PDF]
, 2021 ABSTRACTThe NRC immune receptor network has evolved in asterid plants from a pair of linked genes into a genetically dispersed and phylogenetically structured network of sensor and helper NLR (nucleotide-binding domain and leucine-rich repeat-containing) proteins.
Hiroaki Adachi +6 more
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Interplay between cell‐surface receptor and intracellular NLR‐mediated immune responses
New Phytologist, 2023 SummaryThe functional link between cell‐surface receptors and intracellular NLR immune receptors is a critical aspect of plant immunity. To establish disease, successful pathogens have evolved mechanisms to suppress cell‐surface immune signalling. In response, plants have adapted by evolving NLRs that recognize pathogen effectors involved in this ...
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Structures of plant resistosome reveal how NLR immune receptors are activated [PDF]
aBIOTECH, 2019 Nucleotide-binding domain and leucine-rich repeat (NLR) proteins make up the largest immune receptor family in plants. Although many studies have put effort into revealing the working mechanism of NLRs, the activation details of plant NLRs still remain obscure.
Xuetao Shi, Suomeng Dong, Wende Liu
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Conifers concentrate large numbers of NLR immune receptor genes on one chromosome
Genome Biology and Evolution, 2023 AbstractNucleotide-binding domain and Leucine-rich Repeat (NLR) immune receptor genes form a major line of defence in plants, acting in both pathogen recognition and resistance machinery activation. NLRs are reported to form large gene clusters in limber pine (Pinus flexilis) but it is unknown how widespread this genomic architecture may be among the ...
Yannick Woudstra +13 more
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The value of NLR in predicting the efficacy of preoperative nimotuzumab combined with neoadjuvant chemotherapy for local advanced oral squamous cell carcinoma [PDF]
口腔疾病防治Objective To investigate the value of the peripheral blood neutrophil to lymphocyte ratio (NLR) before nimotuzumab combined with neoadjuvant chemotherapy in predicting the short-term efficacy of neoadjuvant therapy for advanced oral squamous cell ...
TIAN Liangliang, NAN Xinrong
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Plant NLR immunity activation and execution: a biochemical perspective
Open BiologyPlants deploy cell-surface and intracellular receptors to detect pathogen attack and trigger innate immune responses. Inside host cells, families of nucleotide-binding/leucine-rich repeat (NLR) proteins serve as pathogen sensors or downstream mediators ...
Federica Locci, Jane E. Parker
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Scientific ReportsCyclin-dependent kinase 4 and 6 inhibitors (CDK4/6i) are the standard agents for treating patients with estrogen receptor-positive and human epidermal growth factor receptor 2-negative advanced breast cancer (ER + HER2 − ABC). However, markers predicting
Shogo Nakamoto +7 more
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