Results 161 to 170 of about 131,202 (338)
Cancan Huang, Chaotao Zhang, Panpan Yang, Rui Chao, Ziqi Yue, Congshan Li, Jie Guo, Minqi Li Department of Bone Metabolism, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue ...
Huang C+7 more
doaj
Erratum: NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals [PDF]
Peter Duewell+17 more
openalex +1 more source
Klotho controls the brain-immune system interface in the choroid plexus. [PDF]
Located within the brain's ventricles, the choroid plexus produces cerebrospinal fluid and forms an important barrier between the central nervous system and the blood.
Ho, Kaitlyn+7 more
core
Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang+7 more
wiley +1 more source
NLRP3 and CARD8 polymorphisms influence higher disease activity in rheumatoid arthritis [PDF]
Background: The activation of NLRP3-inflammasome may contribute to inflammatory processes in rheumatoid arthritis (RA). Functional polymorphisms in the genes coding for its components NLRP3 and CARD8 were associated with a proinflammatory phenotype.
Jenko Barbara+3 more
doaj
The effects of sodium–glucose cotransporter 2 inhibitors on the ‘forgotten’ right ventricle
Abstract With the progress in diagnosis, treatment and imaging techniques, there is a growing recognition that impaired right ventricular (RV) function profoundly affects the prognosis of patients with heart failure (HF), irrespective of their left ventricular ejection fraction (LVEF).
Liangzhen Qu, Xueting Duan, Han Chen
wiley +1 more source
Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome [PDF]
Christian Bauer+9 more
openalex +1 more source
FDA-approved disulfiram inhibits the NLRP3 inflammasome by regulating NLRP3 palmitoylation
The NLRP3 inflammasome is dysregulated in autoinflammatory disorders caused by inherited mutations and contributes to the pathogenesis of several chronic inflammatory diseases. In this study, we discovered that disulfiram, a safe US Food and Drug Administration (FDA)-approved drug, specifically inhibits the NLRP3 inflammasome but not the NLRC4 or AIM2 ...
Jie Xu+2 more
openaire +2 more sources
Myocardial ketone body oxidation contributes to empagliflozin‐induced improvements in cardiac contractility. Abstract Aims Sodium–glucose cotransporter 2 inhibitors (SGLT2i) improve cardiac performance and clinical outcomes in patients with heart failure, yet mechanisms underlying these beneficial effects remain incompletely understood.
Suzanne Nathalie Voorrips+11 more
wiley +1 more source
New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxicities should be identified and understood beforehand to better prepare patients and physicians, enabling the ...
Alessandra Ghigo+22 more
wiley +1 more source