Results 191 to 200 of about 135,752 (336)

Modulating Macrophage–Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration

Advanced Science, EarlyView.
The G‐CS/MSN drug delivery system enhances intervertebral disc repair through sequential drug release. Abstract Intervertebral disc degeneration (IDD) is characterized by an inflammatory environment and dysregulation of the extracellular matrix metabolism (ECM).
Xiangzhen Kong, Rui Hu, Peng Zhang, Qi Li, Kangle Song, Hanwen Gu, Jihui Zheng, Shen Liu, Liang Liu, Lin Jin, Lei Cheng, Chengwei Li, Zhijian Wei   +12 more
wiley   +1 more source

Zhike Erfang Alleviates MRSA-Induced Pneumonia by Inhibiting TRAF6 and Activating NLRP3 Inflammatory Body

Journal of Inflammation Research
Lian-Qing Zhang,1,* Wen-Can Zheng,2 Wen-Yan Li3,* 1Department of Pharmacy, Shanghai Changhai Hospital, The First Affiliated Hospital of Naval Medical University, Shanghai, China; 2Department of Pharmacy, First People’s Hospital of Qujing City ...
Zhang LQ, Zheng WC, Li WY
doaj  

The NLRP3 Inflammasome Mediates In Vivo Innate Immunity to Influenza A Virus through Recognition of Viral RNA

, 2009
Irving C. Allen, Margaret A. Scull, Chris Moore, Eda K. Holl, Erin McElvania, Debra J. Taxman, Elizabeth H. Guthrie, Raymond J. Pickles, Jenny P.‐Y. Ting   +8 more
openalex   +2 more sources

Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin‐1–Syk and p62/SQSTM1 [PDF]

, 2011
Hye‐Mi Lee, Jae‐Min Yuk, Ki‐Hye Kim, Jichan Jang, Gun Kang, Jin Bong Park, Ji Woong Son, Eun‐Kyeong Jo   +7 more
openalex   +1 more source

Atrial Fibroblasts‐Derived Extracellular Vesicles Exacerbate Atrial Arrhythmogenesis

Advanced Science, EarlyView.
Exosome miR‐224‐5p derived from angiotensin II‐treated atrial fibroblasts creates a substrate for AF by promoting atrial electrical remodeling. Increased exosome miR‐224‐5p enhances AF susceptibility by inhibiting CACNA1c expression and decreasing ICa current of atrial cardiomyocytes.
Yue Yuan, Xinbo Zhao, Xuejie Han, Yukai Cao, Xuexin Jin, Ling Shi, Xin Bi, Desheng Li, Yun Zhang, Wenbo Ma, Jiahui Song, Zhenwei Pan, Zhiren Zhang, Yue Li   +13 more
wiley   +1 more source

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

, 2010
Peter Duewell, Hajime Kono, Katey J. Rayner, Cherilyn M. Sirois, Gregory I. Vladimer, Franz Bauernfeind, George S. Abela, Luigi Franchi, Guillermo G. Nuñez, Max Schnurr, Terje Espevik, Egil Lien, Katherine A. Fitzgerald, Kenneth L. Rock, Kathryn J. Moore, Samuel D. Wright, Veit Hornung, Eicke Latz   +17 more
openalex   +2 more sources

Comparative analysis of short‐term and long‐term LL‐37‐induced rosacea‐like mouse models: Histopathological features and inflammatory immune responses

Animal Models and Experimental Medicine, EarlyView.
The aim of this study was to improve the long‐term LL‐37 mouse model and compare the disease manifestations and pathophysiology of short‐term and long‐term LL‐37‐induced rosacea‐like models. The results show that the long‐term LL‐37 induced mouse model provides a practical animal model for further study of the pathological mechanism of severe rosacea ...
Yiling Wu, Chuanxi Zhang, Hui Jin, Ruiping Zheng, Tian Li, Fuyu Jin, Yaqian Li, Xuemin Gao, Hong Xu, Zhongqiu Wei, Jie Yang   +10 more
wiley   +1 more source

Effects of Dictyophora polysaccharide on cerebellar Purkinje cell degeneration in a chronic alcohol mouse model

Animal Models and Experimental Medicine, EarlyView.
In an ethanol (EtOH)‐treated mouse model, increases in the NLRP3 inflammasome proteins, PC degeneration, and motor coordination disorders were observed. DIP suppressed the NLRP3‐ASC‐caspase‐1 signaling pathway, and alleviated the motor deficits and cerebellar pathological changes in chronic EtOH‐treated mice.
Jian Zhang, Zhihui Dai, Huanhuan Yu, Baofei Sun, Jiuyang Ding, Yuanhe Wang   +5 more
wiley   +1 more source

An Inflammasome-Independent Role for Epithelial-Expressed Nlrp3 in Renal Ischemia-Reperfusion Injury

, 2010
Alana A. Shigeoka, James L. Mueller, Amanpreet Kambo, John C. Mathison, Andrew J. King, Wesley F. Hall, Jean da Silva Correia, Richard J. Ulevitch, Hal M. Hoffman, Dianne B. McKay   +9 more
openalex   +1 more source

Mechanism of Impaired NLRP3 Inflammasome Priming by Monophosphoryl Lipid A [PDF]

, 2011
Chelsea A. Embry, Luigi Franchi, Gabriel Núñez, Thomas C. Mitchell   +3 more
openalex   +1 more source