Results 241 to 250 of about 135,752 (336)

Caspase-8 Blocks Kinase RIPK3-Mediated Activation of the NLRP3 Inflammasome [PDF]

, 2012
Tae‐Bong Kang, Seung‐Hoon Yang, Beáta Tóth, Andrew Kovalenko, David Wallach   +4 more
openalex   +1 more source

Comparative Analysis of Septin Modifiers, Forchlorfenuron and UR214‐9, on Mitochondrial Fragmentation and Lytic Cell Death

Cytoskeleton, EarlyView.
ABSTRACT Septins are conserved GTP‐binding proteins that play key roles in cell division, mitochondrial dynamics and immune responses. Despite their importance to human health, pharmacological compounds to modify septins remain limited. Forchlorfenuron (FCF) was the first small molecule identified to modify septins, disrupting their organisation and ...
Dominik Brokatzky, Rajdeep Das, Hannah Painter, Rakesh K. Singh, Serge Mostowy   +4 more
wiley   +1 more source

Verteporfin attenuates NLRP3 inflammasome activation to alleviate gout arthritis flares. [PDF]

J Inflamm (Lond)
Shippy DC, Ulland TK.
europepmc   +1 more source

NSAIDS AS MODULATORS OF CATION CHANNELS: FENAMATES REPURPOSING IN CHANNELOPATHIES

ChemMedChem, Accepted Article.
Cationic ion channels are transmembrane proteins that regulate the flux of cations (potassium, sodium, and calcium) across cell membrane, playing a pivotal role in many cellular functions. Disruptions of their activity can lead to the so‐called genetic or acquired channelopathies, a heterogeneous group of diseases that affect multiple human systems ...
Paola Laghetti, Concetta Altamura, Simone Dell’Atti, Jean-François Desaphy, Ilaria Saltarella   +4 more
wiley   +1 more source

Involvement of role of HMGB1-NLRP3 pathway in systemic disorders. [PDF]

Front Cell Dev Biol
Yang L, Li X, Zhu X, Ge F, Wang Y.
europepmc   +1 more source

Down-regulation of NLRP3 inflammasome in gingival fibroblasts by subgingival biofilms: Involvement of Porphyromonas gingivalis [PDF]

, 2012
Georgios N. Belibasakis, Bernhard Guggenheim, Nagihan Bostancı   +2 more
openalex   +1 more source

Redefining the Skin Barrier: A Microbiome‐Integrated Multilayered Defense Model

Barrier Immunity, EarlyView.
ABSTRACT The skin constitutes a dynamic interface orchestrating a sophisticated multilayered defense system comprising physical, chemical, immune, and microbial barriers. This review synthesizes current understanding of the structural and functional integration of these barriers, emphasizing their synergistic interactions in maintaining cutaneous ...
Jingjing Xia, Mathias Hochgerner, Qingzhen Wei, Xian'ge Zhong, Jiucun Wang   +4 more
wiley   +1 more source

Prunus mume derived extracellular vesicle-like particles alleviate experimental colitis via disrupting NEK7-NLRP3 interaction and inflammasome activation. [PDF]

J Nanobiotechnology
Lv Q, Yang H, Xie Y, Huang X, Yan Z, Lv Y, Cui Y, Hu L, Qiao H.   +8 more
europepmc   +1 more source

The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes

, 2011
Rebecca C. Coll, Luke O'neill
openalex   +2 more sources

Detection of Base Substitution-Type Somatic Mosaicism of the NLRP3 Gene with >99.9% Statistical Confidence by Massively Parallel Sequencing [PDF]

, 2012
Kazushi Izawa, Atsushi Hijikata, N. Tanaka, Tomoki Kawai, Megumu K. Saito, Raphaela Goldbach‐Mansky, I Aksentijevich, Takahiro Yasumi, Tatsutoshi Nakahata, Toshio Heike, Ryuta Nishikomori, Osamu Ohara   +11 more
openalex   +1 more source