Results 241 to 250 of about 131,202 (338)

Dampening insulin signaling by an NLRP3 'meta-flammasome'

, 2011
Augustine M.K. Choi, Kiichi Nakahira
openalex   +2 more sources

NLRP3 activation induces BBB disruption and neutrophil infiltration via CXCR2 signaling in the mouse brain. [PDF]

J Neuroinflammation
Lee J, Cho W, Yu JW, Hyun YM.
europepmc   +1 more source

The role of gut microbiota‐derived metabolites in neuroinflammation

Neuroprotection, EarlyView.
Gut microbiota‐derived metabolites accumulate in the brain, activating or inhibiting microglia and astrocytes, which affects neuroinflammatory progression. The gut microbiota converts the diet into a variety of metabolites, including bile acid, trimethylamine N‑oxide (TMAO), and indole.
Lingjie Mu, Yijie Wang
wiley   +1 more source

The NLRP3 Inflammasome Contributes to Brain Injury in Pneumococcal Meningitis and Is Activated through ATP-Dependent Lysosomal Cathepsin B Release

, 2011
Tobias Hoegen, Nadin Tremel, Matthias Klein, Barbara Angele, Hermann Wagner, Carsten J. Kirschning, Hans‐Walter Pfister, A. Fontana, Sven Hammerschmidt, Uwe Koedel   +9 more
openalex   +1 more source

Chondrocyte lysates activate NLRP3 inflammasome-induced pyroptosis in synovial fibroblasts to exacerbate knee synovitis by downregulating caveolin-1. [PDF]

Arthritis Res Ther
Du X, Liu R, Jiang Z, Zhang C, Yang Z, Hu S, Zhang Z.   +6 more
europepmc   +1 more source

Mitochondrial transfer as a novel therapeutic approach in ischemic stroke treatment: Current challenges and future perspectives

Neuroprotection, EarlyView.
Cerebral ischemia is a serious neurological disease that mainly leads to pathological changes such as mitochondrial dysfunction, oxidative stress and iron death. Mitochondria play a key role in the regulation of cellular energy metabolism and oxidative stress, and their damage can lead to mitochondrial damage, reduced adenosine triphosphate production,
Shuchen Meng, Min Bai, Changsheng Ma, Bo Han, Mengyuan Duan, Liying Zhang, Jinfen Guo, Changku Shi, Ke Li, Maotao He   +9 more
wiley   +1 more source

The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes

, 2011
Rebecca C. Coll, Luke O'neill
openalex   +2 more sources

Investigation of the mechanism by which miR-223-3p inhibits reflux esophagitis through targeting the NLRP3 inflammasome. [PDF]

BMC Gastroenterol
Lin S, Zheng B, Wu R, Wu Q, Chen X.
europepmc   +1 more source

Role of astrocyte in neuroinflammation‐induced loss in neuroplasticity and subsequent onset of depression: A systematic review

Neuroprotection, EarlyView.
Mechanistic crosstalk between microglia and astrocytes in major depressive disorder. Abstract Major depressive disorder (MDD) is a complex psychiatric condition increasingly linked to chronic neuroinflammation, particularly in the context of aging, stress, and systemic comorbidities.
Gaurav Singhal, Saurabh Singhal, Bernhard T. Baune   +2 more
wiley   +1 more source

Measles Virus V Protein Inhibits NLRP3 Inflammasome-Mediated Interleukin-1β Secretion

, 2011
Noritaka Komune, Takeshi Ichinohe, Minako Ito, Yusuke Yanagi   +3 more
openalex   +1 more source