Results 191 to 200 of about 106,008 (282)

Loss of NKCC1 Activates the NLRP3 Inflammasome in Intestinal Epithelia. [PDF]

Cell Mol Gastroenterol Hepatol
Koumangoye RB, Ferdaus MZ, Davis X, Bohannon JK, Delpire E.   +4 more
europepmc   +1 more source

Dead or alive: how the immune system detects microbial viability

, 2019
Sander, L., Ugolini, M.
core   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Timing of Glucocorticoid Treatment Dictates Glucocorticoid Receptor Actions Modulating the NLRP3-Inflammasome Activation in Macrophages. [PDF]

FASEB J
Diaz-Jimenez D, Oakley RH, Hoffman JA, Bortner CD, Lih F, Li J, Williams JG, Scappini E, Gerrish KE, Garantziotis S, Archer TK, Cidlowski JA.   +11 more
europepmc   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source

PML Is Limiting NLRP3 Inflammasome Activity in Human Endothelial Cells. [PDF]

Cells
Liem CH, Steinemann G, Ghiroltean N, Yvonne Y, Sakr H, Nguyen H, Baum O, Berkholz J.   +7 more
europepmc   +1 more source

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

A new mechanism regulating microglial NLRP3 inflammasome: FMR1 mediates NLRP3 mRNA stability. [PDF]

PLoS One
Deng Q, Bai Q, Yang Y, Tang W, Liu F, Zhang S, Wang H, Xing Z, Zhang C, Yang Y, Fu Q, Fan H.   +11 more
europepmc   +1 more source

Association between serum α‐Klotho levels and severity of periodontitis in a representative U.S. population

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis, a chronic inflammatory disease, is linked to systemic conditions such as cardiovascular and kidney disease. Serum α‐Klotho, an anti‐aging protein with anti‐inflammatory properties, has been associated with systemic diseases, but its role in periodontitis is unclear.
Hamoun Sabri, Sahar Baniameri, Pranav Kataria, Hend Abulatifa, Parham Hazrati, Hom‐Lay Wang, Muhammad H. A. Saleh   +6 more
wiley   +1 more source

Autophagy-NLRP3 Inflammasome Crosstalk in Microglia: A Therapeutic Target for Multiple Sclerosis. [PDF]

Inflammation
Lu JQ, Wang HQ, Fang MR, Ye XM, Song KY.
europepmc   +1 more source