Results 241 to 250 of about 115,042 (335)

NLRP3 Inflammasome Inhibitors for Antiepileptogenic Drug Discovery and Development

Inamul Haque, Pritam Thapa, Douglas M. Burns, Jianping Zhou, Mukut Sharma, Ram Sharma, Vikas Singh   +6 more
openalex   +2 more sources

Epigenetic inflammatory memory and periodontal disease: Mechanisms and clinical significance for comorbidities

Journal of Periodontology, EarlyView.
Abstract Historically, immunological memory was considered an exclusive feature of adaptive immunity. However, innate immune cells have recently been shown to record and maintain epigenetically imprinted memory of earlier infectious or inflammatory challenges.
George Hajishengallis
wiley   +1 more source

NLRP3 Inflammasome and Polycystic Ovary Syndrome (PCOS): A Novel Profile in Adipose Tissue. [PDF]

Int J Mol Sci
Alenezi SA, Alshammari K, Khan R, Amer S.   +3 more
europepmc   +1 more source

HOXA5 Suppresses NEK7‐Mediated Alveolar Epithelial Pyroptosis in Acute Lung Injury by Transcriptionally Inhibiting KAT2A

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Alveolar epithelial cell pyroptosis exacerbates inflammation and tissue damage by releasing inflammatory mediators, thereby promoting the development of acute lung injury (ALI). However, the fundamental mechanism underlying alveolar epithelial cell pyroptosis in ALI has not yet been elucidated. Lipopolysaccharide (LPS) was used to simulate ALI
Lei Wang, Heng Fan, Qi Wang, Cheng‐Jie Jiang, Dan‐Hui Li, Ji‐Hui Ye   +5 more
wiley   +1 more source

TGFβ1 attenuates microglial IL1β release through inhibition of NLRP3 inflammasome priming. [PDF]

Front Immunol
Kalischer C, Potru PS, Lehmann N, Jahn J, Rupp NL, Vidovic N, Russ T, Wiemann S, Spittau B.   +8 more
europepmc   +1 more source

Involvement of the miR‐128‐3p/KDM3A/NLRP3 Axis in High Glucose‐Induced Inflammatory Injury in Retinal Endothelial Cells

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study explores the regulatory mechanism of the miR‐128‐3p in diabetic retinopathy (DR)‐associated inflammatory injury. A cellular model of DR was established by inducing immortalized human retinal endothelial cells (IM‐HRECs) with high‐glucose (HG).
Wei‐Ming Wen, Jian‐Bo Feng, Yin‐Sheng Cai, Nan Lin, Fei Lv, Zhu‐Sheng Guo   +5 more
wiley   +1 more source

Emerging Role of the NLRP3 Inflammasome in the Onset of Oral Diseases and Its Potential as a Therapeutic Target. [PDF]

Int J Mol Sci
Alam MI, Farhana F, Sakai E.
europepmc   +1 more source

Targeting the NLRP3 inflammasome in chronic inflammatory diseases: current perspectives

, 2015
Ema Ozaki, Matthew Campbell, Sarah Doyle
openalex   +2 more sources

MiR‐145‐5p Attenuates Doxorubicin‐Induced Heart Injury Through Targeting Cardiomyocyte Pyroptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Doxorubicin (DOX), a potent anthracycline chemotherapeutic, exhibits dose‐dependent cardiotoxicity that limits its clinical utility. Although miR‐145‐5p demonstrates cardioprotective properties in cardiovascular diseases, its role in DOX‐induced cardiomyopathy remains undefined.
Xing‐Tao Chen, Yong‐Hong Yu, Yan‐Hua Du, Lin Xu, Xiang‐Ping Meng   +4 more
wiley   +1 more source

NLRP3 Inflammasome Inhibition After Pilocarpine-Induced Status Epilepticus Attenuates Chronic Inflammation in Epileptic Mice

Lei Wang, Kai Wang, Yu‐Wen Chen, Xiaoyu Zhang, Wenhao Xu, Zhong Dong, Yu Wang   +6 more
openalex   +1 more source