Results 271 to 280 of about 106,008 (282)
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NLRP3 inflammasome activation after ischemic stroke
Behavioural Brain Research, 2023Cerebral ischemia is a pathological condition resulting from the cessation or reduction of blood supply to the cerebral arteries. Neurological deficits that are clinically relevant can arise as a result of brain damage. The etiology of stroke is multifaceted and intricate, with the inflammatory response being a crucial component that warrants ...
Ping-Ping, Han +4 more
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Leukadherin-1 inhibits NLRP3 inflammasome by blocking inflammasome assembly
International Immunopharmacology, 2023Aberrant activation of the NLRP3 inflammasome has been implicated in the occurrence and development of many inflammatory diseases, and thus potent inhibitors of the NLRP3 inflammasome should be explored. An antitumor agent, Leukadherin-1 (LA-1), tested in phase 1/2 clinical trials, has been reported to exert anti-inflammatory properties by blocking the
Yening Zhang +5 more
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The Nlrp3 inflammasome admits defeat
Trends in Immunology, 2015The Nlrp3 inflammasome triggers interleukin-1 secretion by myeloid cells in response to endogenous and exogenous danger signals. Two recent studies identified the sulfonylurea MCC950 and the ketone metabolite β-hydroxybutyrate as specific inhibitors of the Nlrp3 inflammasome, with promising therapeutic potential for the treatment of auto-inflammatory ...
Christina J. Groß, Olaf Groß
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Methylsulfonylmethane inhibits NLRP3 inflammasome activation
Cytokine, 2015Methylsulfonylmethane (MSM) is an organosulfur compound and the health benefits associated with MSM include inflammation. Although MSM has been shown to have various physiological effects, no study has yet focused on inflammasome activation. The inflammasome is a multiprotein complex that serves as a platform for caspase 1-dependent proteolytic ...
Huijeong, Ahn +5 more
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The NLRP3 inflammasome: activation and regulation
Trends in Biochemical Sciences, 2023The NOD-, LRR- and pyrin domain-containing protein 3 (NLRP3) inflammasome is a cytoplasmic supramolecular complex that is activated in response to cellular perturbations triggered by infection and sterile injury. Assembly of the NLRP3 inflammasome leads to activation of caspase-1, which induces the maturation and release of interleukin-1β (IL-1β) and ...
Jie, Xu, Gabriel, Núñez
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NLRP3 inflammasome activation in inflammaging
Seminars in Immunology, 2018The process of aging is associated with the appearance of low-grade subclinical inflammation, termed inflammaging, that can accelerate age-related diseases. In Western societies the age-related inflammatory response can additionally be aggravated by an inflammatory response related to modern lifestyles and excess calorie consumption, a pathophysiologic
Latz, Eicke, Duewell, Peter
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NLRP3 Inflammasome in Acute Myocardial Infarction
Journal of Cardiovascular Pharmacology, 2019Abstract:Acute myocardial infarction (AMI) is associated with the induction of a sterile inflammatory response that leads to further injury. The NACHT, leucine-rich repeat, and pyrin domain–containing protein 3 (NLRP3) inflammasome is a macromolecular structure responsible for the inflammatory response to injury or infection.
Mauro, Adolfo Gabriele +4 more
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Mitochondrial DNA in NLRP3 inflammasome activation
International Immunopharmacology, 2022As an intracellular polyprotein complex, the NLRP3 inflammasome is activated by NLRP3 perceiving pathogen-related molecular patterns, damage-related molecular patterns(DAMPs), which will result in the secretion of the caspase1-dependent pro-inflammatory cytokines IL1β and IL18, and the cleavage of GSDMD-mediated pyroptosis.
Yanbing Qiu +5 more
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Targeting NLRP3 inflammasome for neurodegenerative disorders
Molecular Psychiatry, 2023Neuroinflammation is a key pathological feature in neurological diseases, including Alzheimer's disease (AD). The nucleotide-binding domain leucine-rich repeat-containing proteins (NLRs) belong to the pattern recognition receptors (PRRs) family that sense stress signals, which play an important role in inflammation.
Jing Yao +3 more
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Flavonoids interfere with NLRP3 inflammasome activation
Toxicology and Applied Pharmacology, 2018NOD-like receptor (NLR) family, pyrin domain-containing 3 (NLRP3) inflammasome is a component of innate immunity, and is responsible for producing mature IL-1β and -18. Several flavonoids were found to affect inflammasome pathway, but the mechanism of action is still obscure.
Hyun Lim +3 more
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