Results 91 to 100 of about 142,714 (313)
Frontiers in Microbiology, 2017 Dodecyl protocatechuate (dodecyl) is a derivative of protocatechuic acid (3,4-dihydroxybenzoic acid) that possesses anti-oxidant and antifungal properties.
Kaila P. Medina-Alarcón +12 more
doaj +1 more source
Scientific Reports, 2023 The human aryl hydrocarbon receptor (AHR) undergoes continuous shuttling between nucleus and cytoplasm. Binding to exogenous or endogenous ligands promotes its rapid nuclear import.
Rashad Haidar +4 more
doaj +1 more source
Advanced Science, EarlyView.FfRlpA2, a conserved Fusarium effector, functions as a protease inhibitor by hijacking the E3 ubiquitin ligase IbCHYR1 to degrade the resistance factor IbZnFR, thereby promoting Fusarium pathogenicity. Conversely, the high dosage Pro::IbZnFRHap2 allele was associated with resistance to root rot disease.
Huan Zhang +14 more
wiley +1 more source
Advanced Science, EarlyView.This study identifies ARID1B as a chromatin‐bound driver of tumor growth in TNBC. ARID1B impairs ARID1A function and directly activates oncogenic programs through SWI/SNF remodeling. Its nuclear localization, mediated by the KPNA2–KPNB1–RANBP2 import machinery, is essential for its tumor‐promoting activity.
Olena Odnokoz +14 more
wiley +1 more source
, 2016 Eind 2015 hebben de gezamenlijke universiteiten, verenigd in de VSNU, opdracht gegeven om onderzoek te doen naar verleden, heden en toekomst van Campus NL: huisvesting en faciliteiten van Nederlandse universiteiten. Dit rapport is het resultaat van dit onderzoek.
openaire +2 more sources
Advanced Science, EarlyView.This study develops an a red/far‐red light‐controlled iPSC‐based vaccines (RIVA) based on the chimeric photosensory protein FnBphP and its interaction partner LDB3 for cancer immunotherapy. The RIVA preserves the multiple intrinsic tumor antigens of iPSCs and enables optogenetic control of the expression of the immune adjuvant type I interferon β under
Longliang Qiao +17 more
wiley +1 more source
Angewandte Chemie, EarlyView.We introduce two methods for incorporating carbazolyl cyanobenzenes onto peptides: a C‐terminus decarboxylative functionalization and a Cys‐selective SNAr reaction. Both conjugates exhibit excellent photoredox/energy‐transfer properties, enabling their use for C‐terminal alkynylation and Cys‐selective thiol‐ene reactions on peptides, as well as ...
Xing‐Yu Liu +4 more
wiley +2 more sources
Advanced Science, Volume 12, Issue 28, July 24, 2025.CRISPR/Cas9, while transformative, faces challenges in specificity, precision, delivery, accessibility, flexibility, and safety. This review addresses these limitations by highlighting strategies to reduce off‐target effects, exploring HDR‐based and alternative editing approaches, and evaluating advanced delivery mechanisms.
Muna Alariqi +8 more
wiley +1 more source
Small RNA Toxin‐Assisted Evolution of GC‐Preferred ErCas12a for Enhanced Genome Targeting Range
Advanced Science, EarlyView.ErCas12a is engineered to target GC‐rich PAMs using a small RNA toxin‐aided positive screening system. The resulting variant, enErCas12a, exhibits an expanded PAM profile and facilitates efficient gene editing in both bacterial and mammalian cells, while preserving high targeting specificity for both canonical and non‐canonical PAM targets.
Zehua Chen +8 more
wiley +1 more source
A Complementarity‐Based Approach to De Novo Binder Design
Advanced Science, EarlyView.A novel method for surface complementarity detection (HECTOR) enables highly efficient docking and design of protein interfaces. Applied to therapeutically relevant targets, this method yields de novo binders with potent antagonistic activity. As a first‐principles approach, HECTOR offers a training‐free solution to the binder design problem and is ...
Kateryna Maksymenko +17 more
wiley +1 more source