Results 81 to 90 of about 157,319 (379)

The subcellular distribution of phosphorylated Y‐box‐binding protein‐1 at S102 in colorectal cancer patients, stratified by KRAS mutational status and clinicopathological features

Molecular Oncology, EarlyView.
This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau, Stephan Forchhammer, Birgit Fehrenbacher, Lejla Mahmutovic, Marcus Scharpf, Gunnar Blumenstock, Martin Schaller, Irina Bonzheim, Shayan Khozooei, Mahmoud Toulany   +9 more
wiley   +1 more source

Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study

Hepatology, EarlyView., 2022
Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study. Abstract Background and Aims Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, and real‐world data are lacking.
Shannon M. Vandriel, Li‐Ting Li, Huiyu She, Jian‐She Wang, Melissa A. Gilbert, Irena Jankowska, Piotr Czubkowski, Dorota Gliwicz‐Miedzińska, Emmanuel M. Gonzales, Emmanuel Jacquemin, Jérôme Bouligand, Nancy B. Spinner, Kathleen M. Loomes, David A. Piccoli, Lorenzo D'Antiga, Emanuele Nicastro, Étienne Sokal, Tanguy Demaret, Noelle H. Ebel, Jeffrey A. Feinstein, Rima Fawaz, Silvia Nastasio, Florence Lacaille, Dominique Debray, Henrik Arnell, Björn Fischler, Susan Siew, Michael Stormon, Saul J. Karpen, Rene Romero, Kyung Mo Kim, Woo Yim Baek, Winita Hardikar, Sahana Shankar, Amin J. Roberts, Helen M. Evans, M. Kyle Jensen, Marianne Kavan, Shikha S. Sundaram, Alexander Chaidez, Palaniswamy Karthikeyan, Maria Camila Sanchez, Maria Lorena Cavalieri, Henkjan J. Verkade, Way Seah Lee, James E. Squires, Christina Hajinicolaou, Chatmanee Lertudomphonwanit, Ryan T. Fischer, Catherine Larson‐Nath, Yael Mozer‐Glassberg, Cigdem Arikan, Henry C. Lin, Jesus Quintero Bernabeu, Seema Alam, Deirdre A. Kelly, Elisa Carvalho, Cristina Targa Ferreira, Giuseppe Indolfi, Ruben E. Quiros‐Tejeira, Pinar Bulut, Pier Luigi Calvo, Zerrin Önal, Pamela L. Valentino, Dev M. Desai, John Eshun, Maria Rogalidou, Antal Dezsőfi, Sabina Wiecek, Gabriella Nebbia, Raquel Borges Pinto, Victorien M. Wolters, María Legarda Tamara, Andréanne N. Zizzo, Jennifer Garcia, Kathleen Schwarz, Marisa Beretta, Thomas Damgaard Sandahl, Carolina Jimenez‐Rivera, Nanda Kerkar, Jernej Brecelj, Quais Mujawar, Nathalie Rock, Cristina Molera Busoms, Wikrom Karnsakul, Eberhard Lurz, Ermelinda Santos‐Silva, Niviann Blondet, Luis Bujanda, Uzma Shah, Richard J. Thompson, Bettina E. Hansen, Binita M. Kamath, The Global ALagille Alliance (GALA) Study Group   +93 more
wiley   +1 more source

A developmental and molecular view of formation of auxin-induced nodule-like structures in land plants

Frontiers in Plant Science, 2016
Several studies have shown that plant hormones play important roles during legume-rhizobia symbiosis. For instance, auxins induce the formation of nodule-like structures (NLS) on legume roots in the absence of rhizobia.
Ryan Hiltenbrand, Jacklyn Thomas, Hannah McCarthy, Karl J Dykema, Ashley Spurr, Hamilton Newhart, Mary E Winn, Arijit Mukherjee   +7 more
doaj   +1 more source

Slow-roll, acceleration, the Big Rip and WKB approximation in NLS-type formulation of scalar field cosmology

, 2008
Aspects of non-linear Schr\"{o}dinger-type (NLS) formulation of scalar (phantom) field cosmology on slow-roll, acceleration, WKB approximation and Big Rip singularity are presented.
Burin Gumjudpai, Calcagni G, Chervon S V Zhuravlev V M, Dauxois T, Dunkley J (WMAP Collaboration), D’Ambroise J, Gibbons G W, Goldhaber G, Gumjudpai B, Gumjudpai B, Gumjudpai B, Gumjudpai B, Hinshaw G (WMAP Collaboration), Kamenshchik A Luzzi M Venturi G, Komatsu E (WMAP Collaboration), Leith B M, Liddle A R, Lidsey J E, Padmanabhan T, Perlmutter S, Phetnora T Sooksan R Gumjudpai B, Riess A G, Riess A G, Riess A G, Riess A G, Sato K, Scranton R (SDSS Collaboration), Spergel D N, Starobinsky A A, Tonry J L, Urena-Lopez L A, Williams F L, Williams F L, Wood-Vasey W M, Wright E L, Yurov A V, Yurov A V Astashenok A V Yurov V A   +36 more
core   +1 more source

On subcellular distribution of the zinc finger 469 protein (ZNF469) and observed discrepancy in the localization of endogenous and overexpressed ZNF469

FEBS Open Bio, EarlyView.
ZNF469 regulates the expression of genes encoding extracellular matrix proteins. Endogenous ZNF469 is predominantly cytoplasmic, while in transfected cells, it forms aggregates reminiscent of biomolecular condensates, located mainly in the nucleus. These condensates exhibit overlapping staining with proteasomes and are also associated with the mitotic ...
Anne Elisabeth Christensen Mellgren, Ileana Cristea, Thomas Stevenson, Endy Spriet, Per Morten Knappskog, Stig Ove Bøe, Harald Kranz, Sushma N. Grellscheid, Eyvind Rødahl   +8 more
wiley   +1 more source

Cognate putative nuclear localization signal effects strong nuclear localization of a GFP reporter and facilitates gene expression studies in Caenorhabditis elegans

BioTechniques, 2007
Targeting a gene expression reporter, usually the green fluorescent protein (GFP), to the nucleus via a translationally fused nuclear localization signal (NLS) greatly facilitates recognition and identification of the reporter-expressing cells in ...
Nicholas N. Lyssenko, Wendy Hanna-Rose, Robert A. Schlegel   +2 more
doaj   +1 more source

Reductions of nonlocal nonlinear Schrödinger equations to Painlevé type functions [PDF]

arXiv, 2021
In this paper, we take ODE reductions of the general nonlinear Schr\"odinger equation (NLS) AKNS system, and reduce them to Painlev\'e type equations. Specifically, the stationary solution is solved in terms of elliptic functions, and the similarity solution is solved in terms of the Painlev\'e IV transcendent.
arxiv  

Comment on "Discretisations of constrained KP hierarchies" [PDF]

, 2014
In the recent paper (R. Willox and M. Hattori, arXiv:1406.5828), an integrable discretization of the nonlinear Schr\"odinger (NLS) equation is studied, which, they think, was discovered by Date, Jimbo and Miwa in 1983 and has been completely forgotten ...
Tsuchida, Takayuki
core  

Nonvanishing boundary conditions and dark solitons in the NLS model

, 2009
We consider non-vanishing boundary conditions (NVBC) for the NLS model [6,7,27] in the context of the hybrid dressing transformation and $\tau$-function approach.
Blas, H., da Silva, M. J. B. F., Santos, L. F. dos   +2 more
core   +1 more source

Alleviation of Aging‐Related Hallmarks in a Mouse Model of Progeria via a Nanoparticle‐Based Artificial Transcription Factor

Advanced Functional Materials, EarlyView.
Oct4‐nanoscript, a biomimetic nanoparticle‐based artificial transcription factor, precisely regulates cellular rejuvenation by activating Oct4 target genes, restoring epigenetic marks, and reducing DNA damage. In a progeria model, it effectively rescued aging‐associated pathologies and extended lifespan.
Hongwon Kim, Junyeop Kim, Euiyeon Lee, Brandon Conklin, Yannan Hou, Sumin Kim, Yerim Hwang, Ki‐Bum Lee, Jongpil Kim   +8 more
wiley   +1 more source