Results 91 to 100 of about 773 (139)

Association of Nucleoside Diphosphate Kinase nm23-H2 with Human Telomeres

Biochemical and Biophysical Research Communications, 1998
Telomeres, the ends of eukaryotic chromosomes, are essential structures formed by specific protein-DNA complexes that protect chromosomes from degradation and end-to-end fusion. TRF1, a double-stranded telomeric TTAGGG-repeat binding protein, is associated with mammalian telomeres and controls telomere length by inhibiting the action of telomerase.
K, Nosaka, M, Kawahara, M, Masuda, Y, Satomi, H, Nishino   +4 more
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Extracellular nucleoside diphosphate kinase NM23/NDPK modulates normal hematopoietic differentiation

Experimental Hematology, 2002
We previously demonstrated the presence of nucleoside diphosphate kinase NDPK/NM23 in normal human plasma. It also was reported that extracellular NM23 could inhibit differentiation of certain hematopoietic cell lines. We further investigated the extracellular effect of NM23 on hematopoiesis by adding recombinant NM23-H1, NM23-H2, and NM23-H3 proteins ...
Willems, Roel, Slegers, Herman, Rodrigus, Inez, Moulijn, Adriaan C., Lenjou, Marc, Nijs, Griet, Berneman, Zwi Nisan, Van Bockstaele, Dirk   +7 more
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NM23/Nucleoside Diphosphate Kinase and Signal Transduction

Journal of Bioenergetics and Biomembranes, 2000
NM23s (or NDP kinases) regulate a fascinating variety of cellular activities, including proliferation, development, and differentiation. All these processes are modulated by external stimuli, leading to the idea that this family of proteins modulates transmembrane signaling pathways.
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The Crystal Structure of Human Nucleoside Diphosphate Kinase, NM23-H2

Journal of Molecular Biology, 1995
The 2.8 A resolution X-ray structure of NM23-H2 has been determined by molecular replacement using the structure of Myxococcus xanthus nucleoside diphosphate (NDP) kinase. NM23-H2 is a human NDP kinase. The enzyme catalyses phosphoryl transfer, binds DNA, and can activate the transcription of the c-myc oncogene in vitro.
P A, Webb, O, Perisic, C E, Mendola, J M, Backer, R L, Williams   +4 more
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Expression of nm23/Nucleoside Diphosphate Kinase-A Protein in Endometrial Carcinoma

Gynecologic Oncology, 1997
A metastatic tumor suppressor role for the nm23 gene product in breast carcinoma has been proposed. The biologic significance of nm23/NDP kinase-A (NDPK-A) expression in endometrial carcinoma remains undetermined. We sought to (1) characterize the pattern and intensity of nm23 protein expression in endometrial carcinoma and (2) assess the relationship ...
P J, Srivatsa, W A, Cliby, G L, Keeney, V J, Suman, W S, Harmsen, S C, Ziesmer, P C, Roche, K C, Podratz   +7 more
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Protein Interactions Provide New Insight into Nm23/Nucleoside Diphosphate Kinase Functions

Journal of Bioenergetics and Biomembranes, 2003
Nm23-NDPKs besides contributing to the maintenance of the cellular nucleoside triphosphate pool, exert regulatory properties in a variety of cellular events including proliferation, invasiveness, development, differentiation, and gene regulation. This review focuses on recently discovered protein-protein interactions involving the Nm23 proteins.
D, Lombardi, A M, Mileo
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Three different genes encode NM23/nucleoside diphosphate kinases in Xenopus laevis

Gene, 1997
Nucleoside diphosphate kinases (NDPKs) catalyse the phosphorylation of nucleoside diphosphates. In mammals, the functional enzyme is a hexamer composed of different amounts of two homologous acidic (A) and basic (B) subunits encoded by separate genes. In prokaryotes and invertebrate eukaryotes, only one cytoplasmic enzyme has been isolated. Other genes
T, Ouatas, B, Abdallah, L, Gasmi, J, Bourdais, E, Postel, A, Mazabraud   +5 more
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Nucleoside diphosphate kinases, nm23, and tumor metastasis: Possible biochemical mechanisms

1993
Tumor metastasis remains the leading cause of death for cancer patients, excluding those with skin cancers. Metastasis is a complex process, requiring tumor cell invasion, motility, arrest and extravasation from the circulatory system, angiogenesis, and avoidance of host immune responses. A considerable list of proteases, motility factors, and adhesion
A, Golden, M, Benedict, A, Shearn, N, Kimura, A, Leone, L A, Liotta, P S, Steeg   +6 more
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A Novel Serine/Threonine‐Specific Protein Phosphotransferase Activity of Nm23/Nucleoside‐Diphosphate Kinase

European Journal of Biochemistry, 1995
Two human nm23 genes have been identified, designated nm23‐H1 and nm23‐H2, which encode the 88% identical nucleoside‐diphosphate kinase (NDPK) A and NDPK B polypeptides, respectively. The nm23‐H1 gene product has been shown to play a functional role in the suppression of tumor metastasis. The Nm23 proteins/NDPK are highly conserved throughout evolution
M, Engel, M, Véron, B, Theisinger, M L, Lacombe, T, Seib, S, Dooley, C, Welter   +6 more
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Nm23-H1/nucleoside diphosphate kinase as a key molecule in breast tumor angiogenesis

Expert Opinion on Therapeutic Targets, 2008
Neo-angiogenesis seems to be a critical feature of breast tumor growth, migration and metastasis. Inhibition of angiogenesis may provide information regarding treatment. Since angiogenesis is the result of complex processes, controlled by several angiogenic (pro- and/or -anti) factors and their receptors, multiple ways to prevent or retrogress tumor ...
BuHyun, Youn, Hag Dong, Kim, Joon, Kim
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