Results 11 to 20 of about 773 (139)
Non‐invasive diagnosis of early cutaneous squamous cell carcinoma
Experimental Dermatology, Volume 32, Issue 11, Page 1946-1959, November 2023., 2023 Abstract Early cutaneous squamous cell carcinoma (cSCC) can be challenging to diagnose using clinical criteria as it could present similar to actinic keratosis (AK) or Bowen's disease (BD), precursors of cSCC. Currently, histopathological assessment of an invasive biopsy is the gold standard for diagnosis.
Ali Azimi +3 more
wiley +1 more source
The FASEB Journal, Volume 37, Issue 9, September 2023., 2023 POLG patient iPSCs‐derived iNSCs with two different mutations, one homozygous (WS5A) and one compound heterozygous (CP2A), were treated with EtBr to induce depletion of mtDNA. While depletion occurred at a similar rate, restoration of mtDNA levels was significantly delayed in CP2A iNSCs.
Cecilie Katrin Kristiansen +5 more
wiley +1 more source
The emerging landscape of eukaryotic polyphosphatases
FEBS Letters, Volume 597, Issue 11, Page 1447-1461, June 2023., 2023 Polyphosphatase enzymes in eukaryotic cells degrade polyphosphate (polyP) chains starting at the end of the chain (exopolyphosphatases), or by cleaving the chain internally to generate two smaller chains (endopolyphosphatases). While there are similarities in proposed polyphosphatases in yeast and mammalian systems, the yeast enzymes are better ...
Liam McCarthy, Michael Downey
wiley +1 more source
Journal of Comparative Neurology, Volume 530, Issue 11, Page 1773-1949, August 2022., 2022 By using a genetically modified mouse model and viral tracing approaches, we mapped both the anterograde and the retrograde projections of a subpopulation of neurons in the anterior paraventricular thalamic nucleus, molecularly defined by the expression of glucokinase (GckaPVT).
Sevasti Gaspari +4 more
wiley +1 more source
Clinical and Translational Science, Volume 15, Issue 4, Page 859-865, April 2022., 2022 Abstract TPMT and NUDT15 variants explain less than 25% of azathioprine‐associated myelotoxicity. There are 25 additional genes in the thiopurine pathway that could also contribute to azathioprine myelotoxicity. We hypothesized that among TPMT and NUDT15 normal metabolizers, a score combining the genetically predicted expression of other proteins in ...
Laura L. Daniel +17 more
wiley +1 more source
Advances in Understanding the Role of Aloe Emodin and Targeted Drug Delivery Systems in Cancer
Oxidative Medicine and Cellular Longevity, Volume 2022, Issue 1, 2022., 2022 Cancer is one of the important causes of death worldwide. Despite remarkable improvements in cancer research in the past few decades, several cancer patients still cannot be cured owing to the development of drug resistance. Natural sources might have prominence as potential drug candidates.
Gökçe Şeker Karatoprak +5 more
wiley +1 more source
Experimental Dermatology, Volume 30, Issue 1, Page 146-161, January 2021., 2021 Abstract Although hypertrophic scars and keloids both generate excessive scar tissue, keloids are characterized by their extensive growth beyond the borders of the original wound, which is not observed in hypertrophic scars. Whether or not hypertrophic scars and keloids are two sides of the same coin or in fact distinct entities remains a topic of much
Grace C. Limandjaja +3 more
wiley +1 more source
Transcriptome Analysis Reveals the Genes Involved in Growth and Metabolism in Muscovy Ducks
BioMed Research International, Volume 2021, Issue 1, 2021., 2021 Muscovy ducks are among the best meat ducks in the world. The objective of this study was to identify genes related to growth metabolism through transcriptome analysis of the ileal tissue of Muscovy ducks. Duck ileum samples with the highest (H group, n = 5) and lowest (L group, n = 5) body weight were selected from two hundred 70‐day‐old Muscovy ducks
Xingxin Wang +6 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 23, Issue 8, Page 4933-4944, August 2019., 2019 Abstract Epigenetic dysregulation plays an important role in cancer. Histone demethylation is a well‐known mechanism of epigenetic regulation that promotes or inhibits tumourigenesis in various malignant tumours. However, the pathogenic role of histone demethylation modifiers in papillary thyroid cancer (PTC), which has a high incidence of early ...
WenQian Zhang +8 more
wiley +1 more source
Managing keloid scars: From radiation therapy to actual and potential drug deliveries
International Wound Journal, Volume 16, Issue 3, Page 852-859, June 2019., 2019 The aetiology of keloids is becoming clearer, but many questions remain, including about the most optimal treatment. Current therapies include surgical excision, radiotherapy, and various pharmaceutical drugs. However, none of these drugs are keloid‐specific. Moreover, all current interventions are associated with high recurrence rates. Here, we review
Chenyu Huang +4 more
wiley +1 more source