Results 51 to 60 of about 28,373 (282)
Advanced Science, EarlyView.Multifunctional oral delivery system—L. reuteri@ZGM—act as both a carrier and therapeutic adjuvant, providing ROS scavenging, and mucin‐interactive properties tailored to the IBD microenvironment. This bioactive gel safeguards L. reuteri from gastric degradation, enhances mucosal adhesion, and promotes long‐term retention at inflamed sites, thereby ...
Mengyun Peng +8 more
wiley +1 more source
F1000Research, 2018 Nonsense-mediated mRNA decay is a eukaryotic pathway that degrades transcripts with premature termination codons (PTCs). In most eukaryotes, thousands of transcripts are degraded by NMD, including many important regulators of development and stress ...
James P. B. Lloyd
doaj +1 more source
Advanced Science, EarlyView.An intelligent engineered probiotic platform is developed for the precision management of inflammatory bowel disease. By integrating surface‐displayed adhesins with an inflammation‐responsive CAT‐SOD‐GPx tripartite fusion system and mucosal repair factors, this programmable system achieves prolonged intestinal retention and multi‐pronged therapy.
Yuxi Wang +9 more
wiley +1 more source
Immunity of the Saccharomyces cerevisiae SSY5 mRNA to nonsense-mediated mRNA decay.
Frontiers in Molecular Biosciences, 2014 The nonsense-mediated mRNA decay (NMD) pathway is a specialized pathway that triggers the rapid degradation of select mRNAs. Initially identified as a pathway that degrades mRNAs with premature termination codons, NMD is now recognized as a pathway that ...
Bessie Wanja Kebaara +3 more
doaj +1 more source
Molecular Interaction of Nonsense-Mediated mRNA Decay with Viruses
Viruses, 2023 The virus–host interaction is dynamic and evolutionary. Viruses have to fight with hosts to establish successful infection. Eukaryotic hosts are equipped with multiple defenses against incoming viruses.
Md Robel Ahmed, Zhiyou Du
doaj +1 more source
Finite Fields and Their Applications, 2013 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Hongxi Tong, Ding Yang
openaire +2 more sources
COX14 Variants Are Associated With Mitochondrial Complex IV Deficiency Nuclear Type 10 (MC4DN10)
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT COX14 encodes a transmembrane protein essential for cytochrome c oxidase (COX) complex assembly. A homozygous missense variant in COX14 was reported in three siblings from a single consanguineous family with severe, fatal infantile mitochondrial complex IV deficiency nuclear type 10 (MC4DN10; MIM# 619053).
Elias K. Awad +7 more
wiley +1 more source
Establishing a reporter assay to identify small molecule NMD inhibitors and new NMD factors
, 2016 The role of nonsense-mediated mRNA decay (NMD) on the manifestation of human disease has been a subject of intense research for decades. The limiting step however for uncovering the physiological role of the surveillance pathway and its implications in ...
Mühlemann, Oliver, Gkratsou, Asimina
core +1 more source
Care for Patients With Neuromuscular Disorders in the COVID-19 Pandemic Era
Frontiers in Neurology, 2021 The coronavirus disease 2019 (COVID-19) pandemic has prompted a rapid and unprecedented reorganization of medical institutions, affecting clinical care for patients with chronic neurological diseases.
Yung-Hao Tseng +2 more
doaj +1 more source
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT CHARGE syndrome is a rare congenital disorder primarily attributed to heterozygous pathogenic variants of the CHD7 gene. Most pathogenic CHD7 variants are loss‐of‐function (LoF) variants, whereas the interpretation of missense variants remains challenging in the absence of functional evidence for their pathogenicity.
Takashi Okuno +8 more
wiley +1 more source